Results 101 to 110 of about 327,068 (394)

Superior Benefits of Combining Mepolizumab With Sinus Surgery Compared to Mepolizumab Alone: Results From a Randomised 6‐Month Trial

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyps (CRSwNP) significantly impacts patients’ quality of life (QoL). Standard treatments include nasal irrigations, nasal steroids, systemic corticosteroids, and functional endoscopic sinus surgery (FESS).
Anne‐Sophie Homøe, Kasper Aanæs, Jens Even Tidemandsen, Haase Christiane Holbaek, Rubek Niclas, Samuelsen Grethe Badsberg, Larsen Bent Ivan Holmegaard, Vibeke Backer   +7 more
wiley   +1 more source

Indoor microbiome, environmental characteristics and asthma among junior high school students in Johor Bahru, Malaysia [PDF]

, 2019
Indoor microbial diversity and composition are suggested to affect the prevalence and severity of asthma. In this study, we collected floor dust and environmental characteristics from 21 classrooms, and health data related to asthma symptoms from 309 students, in junior high schools in Johor Bahru, Malaysia.
arxiv   +1 more source

Modeling temporal gradients in regionally aggregated California asthma hospitalization data [PDF]

Annals of Applied Statistics 2013, Vol. 7, No. 1, 154-176, 2013
Advances in Geographical Information Systems (GIS) have led to the enormous recent burgeoning of spatial-temporal databases and associated statistical modeling. Here we depart from the rather rich literature in space-time modeling by considering the setting where space is discrete (e.g., aggregated data over regions), but time is continuous.
arxiv   +1 more source

Effectiveness of mepolizumab in patients with severe eosinophilic asthma: results from real-world clinical practice in Finland

Journal of Asthma, 2022
Objectives Mepolizumab treatment provides clinical benefits for patients with severe eosinophilic asthma in randomized controlled trials. However, real-world data for patients in Finland are lacking.
Ville Koistinen, P. Kauppi, J. Idänpään-Heikkilä, L. Veijalainen, Ilona Iso-Mustajärvi, T. Ylisaukko‐oja, J. Mehtälä, A. Viinanen, M. Kilpeläinen   +8 more
semanticscholar   +1 more source

Primary care of asthma: new options for severe eosinophilic asthma [PDF]

Current Medical Research and Opinion, 2019
Objective: Asthma is a common heterogeneous disease characterized by airway inflammation and bronchoconstriction. Current treatment guidelines provide recommendations for categorizing disease severity, asthma control and management. This paper reviews asthma assessment in primary care and describes the pathophysiology, clinical characteristics and new ...
Neil Skolnik, Sean P Carnahan
openaire   +2 more sources

Safety of Eosinophil-Depleting Therapy for Severe, Eosinophilic Asthma: Focus on Benralizumab [PDF]

Drug Safety, 2020
Eosinophils play a pivotal role in the inflammatory pathology of asthma and have been the target of new biologic treatments for patients with eosinophilic asthma. Given the central role of interleukin (IL)-5 in the eosinophil lifecycle, several therapies directed against the IL-5 pathway have been developed, including the anti-IL-5 antibodies ...
James Zangrilli, Ubaldo J. Martin, David A. Jackson, Venkata G. Meka, Peter Barker, Stephanie Korn, Sameer K. Mathur   +6 more
openaire   +3 more sources

Differential Immune Cell Infiltration in Eosinophilic and Non‐Eosinophilic CRS: Correlations With Clinical, Endoscopic, and Radiological Findings

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background The pathogenesis of inflammation in eosinophilic chronic rhinosinusitis (ECRS) and non‐eosinophilic chronic rhinosinusitis (NECRS) remains poorly understood. This study aimed to assess immune cell infiltration within the sinonasal microenvironment in these conditions.
Katarzyna Czerwaty, Katarzyna Piszczatowska, Mirosław J. Szczepański, Natalia Jermakow, Nils Ludwig, Karolina Dżaman   +5 more
wiley   +1 more source

Oral corticosteroid-sparing effects of mepolizumab in severe eosinophilic asthma: evidence from randomized controlled trials and real-world studies

Therapeutic Advances in Respiratory Disease, 2022
Oral corticosteroids (OCS) have long been a mainstay of treatment for asthma exacerbations and chronic severe asthma. However, it is increasingly recognized that both long-term and short-term OCS use are directly associated with a wide range of serious ...
T. Casale, A. Burnette, A. Bourdin, P. Howarth, B. Hahn, A. Stach-Klysh, S. Khurana   +6 more
semanticscholar   +1 more source

Blood eosinophil count group shifts and kinetics in severe eosinophilic asthma [PDF]

Annals of Allergy, Asthma & Immunology, 2020
Blood eosinophil count (BEC) measurements are a noninvasive, relatively reliable surrogate marker for eosinophilic airway inflammation. Single measurements of peripheral BEC greater than or equal to 150 cells/μL predict the response to anti-eosinophil therapies for patients with characteristics of severe eosinophilic asthma.To describe how BECs shift ...
Ubaldo J. Martin, James Kreindler, Bill Cook, Frank Trudo, Ian Hirsch, Njira L Lugogo   +5 more
openaire   +3 more sources

Long‐Term Particulate Matter Exposure May Increase Risk of Chronic Rhinosinusitis WIth Nasal Polyposis: Results from an Exposure‐Matched Study

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Particulate matter ⩽2.5 µm in diameter (PM2.5) and its role in chronic rhinosinusitis (CRS) pathogenesis have gained heightened attention. We previously demonstrated that PM2.5 exposure may bias the nasal mucosa in CRS toward a Type 2 inflammatory pathway.
Rory J. Lubner, Mason Krysinski, Ping Li, Rakesh K. Chandra, Justin H. Turner, Naweed I. Chowdhury   +5 more
wiley   +1 more source