Results 101 to 110 of about 93,898 (384)

Twelve-year follow-up study after endoscopic sinus surgery in patients with chronic rhinosinusitis with nasal polyposis [PDF]

, 2019
Background Chronic rhinosinusitis with nasal polyposis (CRSwNP) is a therapeutic challenge because of the high recurrence rate. Surgical intervention should be considered in patients who fail to improve after medical treatment.
Bachert, Claus, Bosteels, Cedric, CALUS, LIEN, Dejonckheere, Sarah, Gevaert, Philippe, Holtappels, Gabriële, VAN BRUAENE, NICHOLAS, Van Zele, Thibaut   +7 more
core   +1 more source

WITHDRAWN: Prospective direct comparison of biological treatments on severe eosinophilic asthma: Findings from the PRISM study [PDF]

, 2023
Duong Duc Pham, Ji‐Hyang Lee, Hyouk‐Soo Kwon, Woo‐Jung Song, You Sook Cho, Hyun‐Kyoung Kim, Jae‐Woo Kwon, So‐Young Park, Sujeong Kim, Gyu Young Hur, Byung‐Keun Kim, Young‐Hee Nam, Min‐Suk Yang, Mi‐Yeong Kim, Sae‐Hoon Kim, Byung‐Jae Lee, Taehoon Lee, So‐Young Park, Min‐Hye Kim, Young-Joo Cho, Chan Sun Park, Jae‐Woo Jung, Han Ki Park, Joo‐Hee Kim, Ji‐Yong Moon, Pankaj Bhavsar, Ian M. Adcock, Kian Fan Chung, Tae-Bum Kim   +28 more
openalex   +1 more source

Cadherin‐26 Facilitates Transepithelial Migration of Eosinophils in Eosinophilic Chronic Rhinosinusitis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Eosinophilic chronic rhinosinusitis with nasal polyps (eCRSwNP) is characterized by persistent sinonasal inflammation and marked eosinophilic infiltration. Although the relationship between eosinophils and NP formation has been extensively studied, the mechanisms governing eosinophil transepithelial migration into the nasal mucosa ...
Yeong‐In Jo, Jee Won Moon, Joo‐Hoo Park, Hwa Eun Yang, Subin Cho, Hyeongguk Son, Hyun‐Woo Yang, Il‐Ho Park   +7 more
wiley   +1 more source

New and developing non-adrenoreceptor small molecule drugs for the treatment of asthma [PDF]

, 2017
Introduction: Inhaled corticosteroids (ICS) alone or in combination with an inhaled long-acting beta2-agonist (LABA) are the preferred long-term treatment for adults and adolescents with symptomatic asthma.
Thomson, Neil C.
core   +1 more source

Eosinophils as Drivers of Severe Eosinophilic Asthma: Endotypes or Plasticity?

International Journal of Molecular Sciences, 2021
Asthma is now recognized as a heterogeneous disease, encompassing different phenotypes driven by distinct pathophysiological mechanisms called endotypes.
Glenn Van Hulst, F. Bureau, C. Desmet
semanticscholar   +1 more source

The Global Airways in Practice: Long‐term Effects of Mepolizumab With or Without FESS on Type 2 Inflammation in Patients With CRSwNP

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is a type 2 inflammatory disease often associated with asthma. The global airway hypothesis suggests bidirectional inflammatory interactions between upper and lower airways. Mepolizumab, an anti–IL‐5 therapy, treats conditions systemically, while functional endoscopic sinus surgery ...
Jens Tidemandsen, Vibeke Backer, Anne Sophie Homøe, Thomas H. L. Jensen, Kasper Aanæs, Howraman Meteran, Morten Hostrup, Lukas Moesgaard, Christiane Haase, Peter G. Gibson   +9 more
wiley   +1 more source

Allergens, germs and asthma [PDF]

, 2015
Objective To explore asthma pathogenesis using data from upper and lower airways. Data Source English-language papers on human asthma and nasal polyp subjects from 1990 onwards.
Scadding, GK
core  

A transcriptome-driven analysis of epithelial brushings and bronchial biopsies to define asthma phenotypes in U-BIOPRED [PDF]

, 2016
RATIONALE AND OBJECTIVES: Asthma is a heterogeneous disease driven by diverse immunologic and inflammatory mechanisms. We used transcriptomic profiling of airway tissues to help define asthma phenotypes. METHODS: The transcriptome from bronchial biopsies
Adcock, IM, Auffray, C, Baribaud, F, Chanez, P, Chung, KF, Corfield, J, Dahlen, B, Dahlen, SE, De Meulder, B, Djukanovic, R, Fleming, L, Fowler, S, Guo, Y, Hoda, U, Howarth, P, Krug, N, Kuo, CS, Lefaudeux, D, Loza, M, Pandis, I, Pavlidis, S, Rossios, C, Rowe, A, Sandström, T, Shaw, D, Sousa, A, Sterk, PJ, U-BIOPRED Project Team, Wilson, SJ   +28 more
core   +4 more sources

Distinct trajectories of treatment response to mepolizumab toward remission in patients with severe eosinophilic asthma

European Respiratory Journal
Graphical abstract Overview of the study. OCS: oral corticosteroid; ACQ-5: Asthma Control Questionnaire (5-item); FEV1: forced expiratory volume in 1 s. Background Patients with severe eosinophilic asthma, characterised by a high disease burden, benefit ...
Yuto Hamada, Dennis Thomas, E. Harvey, S. Stevens, M. Fricker, H. Lewthwaite, Vanessa M. McDonald, Andrew Gillman, M. Hew, V. Kritikos, J.W. Upham, P. Gibson   +11 more
semanticscholar   +1 more source

Benefit of switching to mepolizumab from omalizumab in severe eosinophilic asthma based on patient characteristics

Respiratory Research, 2021
Background The OSMO study assessed the efficacy of switching to mepolizumab in patients with severe eosinophilic asthma that was uncontrolled whilst receiving omalizumab.
M. Liu, B. Chipps, X. Muñoz, G. Devouassoux, M. Bergna, Steven G. Smith, R. Price, Dmitry Galkin, J. Azmi, Dalal Mouneimne, F. Albers, K. Chapman   +11 more
semanticscholar   +1 more source