Results 121 to 130 of about 93,898 (384)

Eosinophils Target Therapy for Severe Asthma: Critical Points [PDF]

BioMed Research International, 2018
Asthma is a chronic and heterogeneous disease, which is defined as severe disease whenever it requires treatment with a high dose of inhaled corticosteroids plus a second controller and/or systemic corticosteroids to prevent it from becoming ‘‘uncontrolled’’ or if it remains ‘‘uncontrolled’’ despite this therapy.
Brussino, L., Heffler, E., Bucca, C., Nicola, S., Rolla, G.   +4 more
openaire   +3 more sources

Myo‐Inositol Mitigates Oxidative Stress in Bovine Mammary Epithelial Cells via Activation of the SIRT5/Nrf2 Signaling Axis

Animal Research and One Health, EarlyView.
Myo‐inositol alleviates oxidative stress in dairy cow mammary epithelial cells via the Sirt5/Nrf2 pathway to promote mitochondrial fusion. This graphical abstract was created with BioRender.com. ABSTRACT High‐yielding dairy cows are susceptible to mammary gland oxidative stress due to prolonged intensive lactation, leading to redox imbalance.
Yufei Zhang, Yu Cao, Meng Zhang, Huijie Hu, He Ma, Junlong Bi, Juxiong Liu, Shoupeng Fu, Wenjin Guo   +8 more
wiley   +1 more source

Aerodigestive evaluation in patients with eosinophilic asthma

Respiratory Medicine Case Reports
We present two pediatric patients with severe uncontrolled asthma who underwent aerodigestive evaluation revealing eosinophilic asthma and eosinophilic esophageal inflammation.
Chloe Citron, Jessica Erkman, Mikhail Kazachkov, Anna Nowak-Wegrzyn, Deniz Kesebir   +4 more
doaj   +1 more source

The effects of anti-sense interleukin-5 gene transferred by recombinant adeno-associated virus in allergic rats [PDF]

, 2008
The accumulation and infiltration of eosinophils in airways is one of the most important characteristics of asthma, and is mediated partly by secretion of IL-5 from Th2 lymphocytes.
Chao Cao, Daxiong Zeng, Qingfeng Song, Weining Xiong, Xiansheng Liu, Yong Cao, Yongjian Xu   +6 more
core   +1 more source

S63 Long-term effectiveness of anti-IL4R therapy following suboptimal response to anti-IL5/5R therapy in severe eosinophilic asthma [PDF]

, 2023
Jessica Gates, M Fernandes, A Hearn, L Green, Louise Thomson, C Roxas, J Lam, G d’Ancona, AM Nanzer, J Dhariwal, DJ Jackson   +10 more
openalex   +1 more source

Severe eosinophilic asthma in Chinese C‐BIOPRED asthma cohort [PDF]

Clinical and Translational Medicine, 2022
Qingling Zhang, Xiuhua Fu, Changzheng Wang, Huahao Shen, Lei Zhu, Guochao Shi, Zhongmin Qiu, Zhongguang Wen, Wei Gu, Wei Luo, Lina Zhao, Yunqin Chen, Sam Lim, Chang Xiao, Jian Kang, Yunhui Zhang, Mao Huang, Jinfu Xu, Kewu Huang, Qiang Li, Xiangyan Zhang, Jianping Zhao, Xiaoxia Liu, Shenghua Sun, Huaping Tang, Bei He, Shaoxi Cai, Ping Chen, Chunhua Wei, Guangfa Wang, Ping Chen, Lixin Xie, Jiangtao Lin, Yuling Tang, Zhihai Han, Kian Fan Chung, Nanshan Zhong, the C‐BIOPRED consortium   +37 more
openaire   +3 more sources

The Effect of Benralizumab and Mepolizumab on Use of Oral Glucocorticoids in Patients With Eosinophilic Granulomatosis With Polyangiitis

Arthritis &Rheumatology, EarlyView.
Objective The phase 3 MANDARA study demonstrated noninferiority of benralizumab versus mepolizumab for remission in patients with eosinophilic granulomatosis with polyangiitis (EGPA). More benralizumab‐treated patients achieved complete withdrawal of oral glucocorticoids (OGCs).
Parameswaran K. Nair, Bernhard Hellmich, Arnaud Bourdin, David R. W. Jayne, Florence Roufosse, Nader Khalidi, Lena Börjesson Sjö, Ying Fan, Christopher McCrae, Sofia Necander, Eva Rodríguez‐Suárez, Anat Shavit, Claire Walton, Peter A. Merkel, Michael E. Wechsler   +14 more
wiley   +1 more source

The Comparative Effectiveness of Mepolizumab and Benralizumab in the Treatment of Eosinophilic Asthma

Advances in Respiratory Medicine
Background: Severe asthma is associated with significant morbidity and risk of complications. Some patients, suffering from eosinophilic asthma, may benefit from biological therapies, especially anti IL-5 (anti-interleukin-5).
Aleksandra Niemiec-Górska, Olga Branicka, Paula Olszewska, Sylwia Mielcarska, Joanna Glück, Barbara Rymarczyk, Radosław Gawlik   +6 more
doaj   +1 more source

Bronchoscopy, Imaging, and Concurrent Diseases in Dogs with Bronchiectasis: (2003-2014). [PDF]

, 2015
BackgroundBronchiectasis is a permanent and debilitating sequel to chronic or severe airway injury, however, diseases associated with this condition are poorly defined.ObjectiveTo evaluate results of diagnostic tests used to document bronchiectasis and ...
Byrne, BA, Johnson, EG, Johnson, LR, Kass, PH, Vernau, W   +4 more
core   +1 more source

Allergic bronchopulmonary aspergillosis: diagnostic and treatment challenges [PDF]

, 2016
Allergic bronchopulmonary aspergillosis (ABPA) is a pulmonary disorder, occurring mostly in asthmatic and cystic fibrosis patients, caused by an abnormal T-helper 2 lymphocyte response of the host to Aspergillus fumigatus antigens.
CINICOLA, BIANCA LAURA, DUSE, MARZIA, Laitano, Rossella, LEONARDI, LUCIA   +3 more
core   +1 more source