Results 231 to 240 of about 93,898 (384)

The Nasal Microbiome and Associations With Environmental Exposures and Respiratory Health

Allergy, EarlyView.
This study evaluates the association of the nasal microbiome with air pollutants, meteorological conditions, and respiratory health in adolescents. Bacterial diversity is positively associated with hay fever and short‐term NO2 exposure, and negatively with temperature. A Moraxella‐dominated nasotype is linked to lower O3 exposure and higher temperature
Javier Perez‐Garcia, Anne K. Bozack, Sheryl L. Rifas‐Shiman, Yanjiao Zhou, Joanne Sordillo, Brent Coull, Heike Luttmann‐Gibson, Joel Schwartz, Marie‐France Hivert, Emily Oken, Diane R. Gold, Andres Cardenas   +11 more
wiley   +1 more source

Clinical remission in patients with severe eosinophilic asthma treated with benralizumab over 24 months: Post hoc analysis of the ANANKE study. [PDF]

World Allergy Organ J
Canonica GW, Senna G, Brussino L, Aliani M, Altieri E, Bracciale P, Caiaffa MF, Cameli P, Caminati M, Caruso C, Centanni S, De Michele F, Del Giacco S, Di Marco F, Malerba L, Menzella F, Rogliani P, Romagnoli M, Schino P, Schroeder JW, Vultaggio A, D'Amato M, Pelaia G.   +22 more
europepmc   +1 more source

Mediation of Polygenic Asthma Risk Through Gene Expression

Allergy, EarlyView.
We apply published PRSs in African‐ancestry individuals and quantify the extent to which the PRS‐asthma relationship is mediated by clinical biomarkers and gene‐expression signatures of asthma. We found the best PRS to be the one derived using the largest sample size and including African‐ancestry individuals.
Rakesh Natarajan, Brooke Szczesny, Kanika Kanchan, Erika Esquinca, Meher Preethi Boorgula, Sameer Chavan, Monica Campbell, Wendy Lorizio, Ayo P. Doumatey, Alvaro A. Cruz, Harold Watson, Edward T. Naureckas, B. Louise Giles, Ganiyu Arinola, Olumide Sogaolu, Adegoke G. Falade, Nadia N. Hansel, Christopher O. Olopade, Charles N. Rotimi, R. Clive Landis, Camila A. Figueiredo, Eimear E. Kenny, Ingo Ruczinski, Andrew H. Liu, Carole Ober, Margaret A. Taub, Randi K. Johnson, Kathleen C. Barnes, Genevieve L. Wojcik, Rasika A. Mathias   +29 more
wiley   +1 more source

Persistent airway obstruction in severe eosinophilic asthma: targeting interleukin-5 and eosinophils. [PDF]

Eur Respir Rev
Hanania NA, Herth FJF.
europepmc   +1 more source

Protective Role for Itaconate During Inhaled Allergen Challenge

Allergy, EarlyView.
Itaconate levels decrease in sputum following allergen inhalation in mild asthmatics, suggesting a dynamic metabolic response to airway challenge. Genetic deletion of Acod1 in mice did not alter airway inflammation or remodelling in response to chronic HDM exposure.
Gesa J. Albers, Patricia P. Ogger, Christina Michalaki, Helen Stölting, Simone A. Walker, Anna Caldwell, John M. Halket, Kathryn Duvall, Atia Batool, Lisha Joshi, Helen O'Brien, Cormac McCarthy, Timothy Hinks, Gail M. Gauvreau, Paul M. O'Byrne, Clare M. Lloyd, Adam J. Byrne   +16 more
wiley   +1 more source

Unmasking EGPA with near fatal diffuse alveolar haemorrhage in severe eosinophilic asthma under treatment with benralizumab: a case report. [PDF]

BMC Pulm Med
Drick N, Kaireit TF, Ruwisch J, Schallhorn S, Bauersachs J, Schenk H, Hoeper MM, Witte T, Seeliger B.   +8 more
europepmc   +1 more source

Bidirectional Associations Between Seborrheic Dermatitis and Epithelial Barrier Diseases: A Retrospective Cohort Study

Allergy, EarlyView.
This study explores the bidirectional associations between SD and EBDs in a cohort of 5,083,689 individuals in a US administrative claims database. Positive bidirectional associations were found between SD and many EBDs of the skin, respiratory, gastrointestinal, and ocular surfaces. Our results support the EBT as a shared driver of EBD pathogenesis at
Sabrina Meng, Ronald Berna, Junko Takeshita, Ole Hoffstad, Daniel Shin, Nandita Mitra, David J. Margolis   +6 more
wiley   +1 more source

Can Coexisting Allergic Rhinitis in Patients with Severe Eosinophilic Asthma Be a Prognostic Factor for Efficacy of Biological Therapy? Analysis of Eosinophilic Involvement. [PDF]

J Clin Med
Jura-Szołtys E, Glück J, Klimek L, Gawlik R.   +3 more
europepmc   +1 more source

Long-Term Clinical and Sustained REMIssion in Severe Eosinophilic Asthma treated with Mepolizumab: The REMI-M study

medRxiv
C. Crimi, S. Nolasco, A. Md, A. Md, V. Quaranta, Danilo Di Bona Md, G. Md, F. Papia, Maria Filomena Caiaffa Md, Cecilia Calabrese, Maria D'Amato, C. Pelaia, R. Campisi, C. Vitale, Luigi Ciampo, S. Dragonieri, Elena Minenna, Federica Massaro, L. Gallotti, L. Md, M. Md, N. Md, G. Valenti, G. Pelaia, Maria Pia, Foschino Barbaro, G. E. Carpagnano, Alessandro Vatrella, N. Crimi, Prof. Claudia Crimi, Danilo Di Bona, M. Caiaffa, Maria D'Amato, G. E. Carpagnano, Andrea Alessia, Maria Irene Quarato, Francesca Montagnolo, D. F. Mariniello   +37 more
semanticscholar   +1 more source

Club Cells in Nasal Epithelial Repair: Insights From an IL‐13‐Induced Inflammatory Model

Allergy, EarlyView.
Four inflammatory endotypes of CRSwNP, defined by eosinophil and neutrophil infiltration, show distinct patterns of basal, club, ciliated, and goblet cell expression in nasal epithelium. Using an ALI‐HNECs model, we demonstrate that IL‐13 impairs mucociliary function by promoting club‐to‐goblet cell differentiation while inhibiting club‐to‐ciliated ...
Zhi‐Qun Huang, Jing Liu, Jing Ye, Li‐Ying Sun, Hsiao Hui Ong, Yang Peng, Bing‐Qi Lin, Jun‐Hao Tu, Ke‐Shuang Wang, Yi‐Shan Xiong, Qing Luo, Mark Thong, Yu Xu, De‐Yun Wang   +13 more
wiley   +1 more source