Results 241 to 250 of about 1,917,601 (292)

Effects of azithromycin in severe eosinophilic asthma with concomitant monoclonal antibody treatment. [PDF]

Thorax
Lavoie G, Howell I, Melhorn J, Borg C, Bermejo-Sanchez L, Seymour J, Jabeen MF, Fries A, Hynes G, Pavord ID, Petousi N, Hinks TS.   +11 more
europepmc   +1 more source

Early and Sustained Clinical Benefits of Benralizumab in Severe Eosinophilic Asthma: Findings from the ORBE II Study. [PDF]

J Clin Med
Ausín P, Navarrete-Rouco ME, Carazo L, Sanchez-Trincado JL, Luzon E, Nuevo J, Santín M, Sánchez J, Padilla-Galo A.   +8 more
europepmc   +1 more source

Longitudinal multi-trajectory phenotypes of severe eosinophilic asthma on type 2 biologics treatment. [PDF]

World Allergy Organ J
Pham DD, Lee JH, Kwon HS, Song WJ, Cho YS, Kim H, Kwon JW, Park SY, Kim S, Hur GY, Kim BK, Nam YH, Yang MS, Kim MY, Kim SH, Lee BJ, Lee T, Park SY, Kim MH, Cho YJ, Park C, Jung JW, Park HK, Kim JH, Moon JY, Bhavsar P, Adcock IM, Chung KF, Kim TB.   +28 more
europepmc   +1 more source

The Effect of Mepolizumab on Blood Eosinophil Subtype Distribution and Granule Protein Gene Expression in Severe Eosinophilic Asthma. [PDF]

J Asthma Allergy
Rimkunas A, Januskevicius A, Vasyle E, Palacionyte J, Kalinauskaite-Zukauske V, Miliauskas S, Malakauskas K.   +6 more
europepmc   +1 more source

Effect of the Arg16Gly β₂-Adrenergic Receptor Polymorphism on Long-Term Mepolizumab Response and Clinical Remission in Severe Eosinophilic Asthma: A Genotype-Stratified, Multicenter Study. [PDF]

Allergy
Nolasco S, Fagone E, Campisi R, Portacci A, Scioscia G, Pelaia C, Maglio A, Candia C, Quaranta VN, Carrieri I, Saglia A, Vatrella A, Pelaia G, Vancheri C, Foschino Barbaro MP, D'Amato M, Carpagnano GE, Crimi N, Crimi C, Southern Italy Network on Severe Asthma Therapy.   +19 more
europepmc   +1 more source

Consensus from European experts on severe eosinophilic asthma and chronic rhinosinusitis with nasal polyps: Results from the OverSEA Delphi study. [PDF]

J Allergy Clin Immunol Glob
Bachert C, Brusselle G, Castillo Vizuete JA, Dávila I, Laudien M, Seccia V, Schmid-Grendelmeier P, Vultaggio A, Kallinikou K, Walrave L, Klimek L.   +10 more
europepmc   +1 more source

Biomarkers for Severe Eosinophilic Asthma [PDF]

Journal of Allergy and Clinical Immunology, 2017
The last decade has seen the approval of several new biologics for the treatment of severe asthma-targeting specific endotypes and phenotypes. This review will examine how evidence generated from the mepolizumab clinical development program showed that blood eosinophil counts, rather than sputum or tissue eosinophil counts, evolved as a pharmacodynamic
Frank Albers, Hector Ortega, Ian D. Pavord   +2 more
exaly   +6 more sources

Mepolizumab Treatment in Patients With Severe Eosinophilic Asthma [PDF]

New England Journal of Medicine, 2014
Some patients with severe asthma have frequent exacerbations associated with persistent eosinophilic inflammation despite continuous treatment with high-dose inhaled glucocorticoids with or without oral glucocorticoids.In this randomized, double-blind, double-dummy study, we assigned 576 patients with recurrent asthma exacerbations and evidence of ...
Guy Brusselle, Alfredo Chetta, Hector Ortega   +2 more
exaly   +5 more sources

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Clusters of Severe Eosinophilic Asthma in a Korean Asthma Cohort

Respiration, 2021
<b><i>Background:</i></b> Targeted therapies have broadened the available treatment options for patients with severe eosinophilic asthma (SEA). However, differences in the magnitude of treatment responses among patients indicate the presence of various underlying pathophysiological processes and patient subgroups. <b><i&
Ji-Hyang Lee, Jin An, Ha-Kyeong Won, Bomi Seo, Jung-Hyun Kim, So-Young Park, Min-Hye Kim, Yoo Seob Shin, Jae-Woo Jung, Woo-Jung Song, Taehoon Lee, Hyouk-Soo Kwon, Jae Hyun Lee, Joo-Hee Kim, Sae-Hoon Kim, Yoon-Seok Chang, You Sook Cho, Dong-Ho Nahm, An-Soo Jang, Jung-Won Park, Ho-Joo Yoon, Sang-Heon Cho, Young-Joo Cho, Byoung Whui Choi, Hee-Bom Moon, Tae-Bum Kim   +25 more
openaire   +2 more sources