Anti-interleukin-5 therapy (mepolizumab) in life-threatening asthma attack: A case-based discussion
Respiratory Medicine Case Reports, 2019 We report about a case of a compassionate off-label use of the anti-interleukin-5-agent mepolizumab in a ventilated patient with life-threatening asthma attack in eosinophilic asthma.
Khodr Tello +12 more
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New therapy options for patients with eosinophilic type of severe bronchial asthma
Медицинский совет, 2020 The article provides data on the epidemiology of severe asthma. It defines the phenotype and endotype of bronchial asthma and classifies BA according to phenotype/endotype.
G. L. Ignatova +4 more
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Sputum Hyaluronan and Versican in Severe Eosinophilic Asthma [PDF]
International Archives of Allergy and Immunology, 2012 <b><i>Background:</i></b> We examined levels of hyaluronan, a matrix glycosaminoglycan and versican, a matrix proteoglycan, in the sputum of asthmatics treated with mepolizumab (anti-IL-5 monoclonal antibody) versus placebo to evaluate the utility of these measurements as possible biomarkers of asthma control and airway ...
Andrew G, Ayars +5 more
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Real-World Impact of Mepolizumab on the Oral Corticosteroid Freedom Component of Clinical Remission in Severe Eosinophilic Asthma: International, Prospective REALITI-A Study [PDF]
, 2023 Geoffrey Chupp +7 more
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WITHDRAWN: Prospective direct comparison of biological treatments on severe eosinophilic asthma: Findings from the PRISM study [PDF]
, 2023 Duong Duc Pham +28 more
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S63 Long-term effectiveness of anti-IL4R therapy following suboptimal response to anti-IL5/5R therapy in severe eosinophilic asthma [PDF]
, 2023 Jessica Gates +10 more
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Eosinophilic Asthma: Pathophysiology and Therapeutic Horizons
CellsAsthma is a prevalent chronic non-communicable disease, affecting approximately 300 million people worldwide. It is characterized by significant airway inflammation, hyperresponsiveness, obstruction, and remodeling.
Musaddique Hussain, Gang Liu
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Sputum autoantibodies in patients with severe eosinophilic asthma [PDF]
Journal of Allergy and Clinical Immunology, 2018 The persistence of eosinophils in sputum despite high doses of corticosteroids indicates disease severity in asthmatic patients. Chronic inflamed airways can lose tolerance over time to immunogenic entities released on frequent eosinophil degranulation, which further contributes to disease severity and necessitates an increase in maintenance ...
Manali, Mukherjee +12 more
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Cellular Mechanisms Underlying Eosinophilic and Neutrophilic Airway Inflammation in Asthma
Mediators of Inflammation, 2015 Asthma is a phenotypically heterogeneous chronic disease of the airways, characterized by either predominant eosinophilic or neutrophilic, or even mixed eosinophilic/neutrophilic inflammatory patterns. Eosinophilic inflammation can be associated with the
Girolamo Pelaia +6 more
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P203 Effectiveness of anti-IL4R therapy following Suboptimal Response to anti-IL5/5R therapy in severe eosinophilic asthma [PDF]
, 2021 TW Mason +9 more
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