Results 61 to 70 of about 2,162 (133)

Sevoflurane Exposure Induces Neuronal Cell Parthanatos Initiated by DNA Damage in the Developing Brain via an Increase of Intracellular Reactive Oxygen Species

Frontiers in Cellular Neuroscience, 2020
The safety of volatile anesthetics in infants and young children has been drawing increasing concern due to its potential neurotoxicity in the developing brain. Neuronal death is considered a major factor associated with developmental neurotoxicity after
Meihua Piao, Yingying Wang, Nan Liu, Xuedong Wang, Rui Chen, Jing Qin, Pengfei Ge, Chunsheng Feng   +7 more
doaj   +1 more source

Using a Patient‐Reported Outcome (PRO) Questionnaire to Assess Postoperative Care Following Pediatric Outpatient Surgery

Pediatric Anesthesia, EarlyView.
ABSTRACT Introduction In recent years, there has been a marked rise in the incidence of pediatric day surgery across Western countries. As postoperative recovery transitions to the home environment, it is incumbent on healthcare systems to develop methods for patient follow‐up and caregiver support.
Hjördis Osk Atladottir, Anne Treschow Phillipsen, Karen Arnt Krøyer, Anne Gade Jensen, Liv Marit Valen Schougaard, Peter Ahlburg   +5 more
wiley   +1 more source

Sevoflurane pretreatment attenuates hypoxia/reoxygenation-induced cardiomyocyte apoptosis through activation of AKT/pim-1 and AKT/GSK3β signaling pathways

Biotechnology & Biotechnological Equipment, 2019
Myocardial ischemia-reperfusion injury (IRI) is a severe trauma which is characterized by inflammatory reaction, oxidative stress and cardiomyocyte apoptosis.
Wensheng Zhao, Tieshan Zhang, Lulu Xu, Yue Yang, Yingchao Wang, Zhenni Jiang   +5 more
doaj   +1 more source

Phentolamine Infusion for the Treatment of Norepinephrine Extravasation in a Dog

Journal of Veterinary Emergency and Critical Care, EarlyView.
ABSTRACT Objective To describe a case of clinically significant norepinephrine extravasation in a dog with a successful outcome following the use of subcutaneous phentolamine infusion. Case Summary An 8‐year‐old male neutered Labrador Retriever experienced norepinephrine extravasation from a cephalic, peripheral intravenous catheter while under ...
Grace E. Flynn, Cody I. Riffe, Kathleen M. Aicher, Lance R. Wheeler   +3 more
wiley   +1 more source

Chest wall lift for thoracoscopic lung lobectomy: Technique and results in two cats

Veterinary Surgery, EarlyView.
Abstract Objective To report the technique and outcomes of utilizing chest wall lift to perform thoracoscopic surgery in two cats. Study design Short case series. Animals Client‐owned cats (n = 2). Methods A geriatric cat was referred for pleural effusion secondary to a left cranial lung lobe mass. A thoracoscopic exploration of the left hemithorax was
Adrien Aertsens, Helen Tsoi, Micah Esala, Emily P. Wheeler   +3 more
wiley   +1 more source

Effects of noradrenaline and phenylephrine on cerebral oxygen saturation during cardiopulmonary bypass in cardiac surgery

Experimental Physiology, EarlyView.
Abstract Cardiopulmonary bypass (CPB) in cardiac surgery is associated with a high risk of postoperative neurological complications. Perioperative use of vasopressors is common to counteract arterial hypotension in this setting. However, use of α‐agonist vasopressors has been associated with cerebral desaturations.
Edouard Marques, Etienne J. Couture, Jean S. Bussières, Stephan Langevin, Paul Poirier, Pierre Voisine, Manon Caouette, Patrice Brassard   +7 more
wiley   +1 more source

Lactate orchestrates metabolic hemodynamic adaptations through a unique combination of venocontraction, artery relaxation, and positive inotropy

Acta Physiologica, Volume 241, Issue 5, May 2025.
Abstract Aim H+ facilitates metabolic blood flow regulation while negatively impacting cardiac contractility. Cardiovascular consequences of conjugate bases accumulating alongside H+ remain unclear. Here, we evaluate the cardiovascular effects of nine prominent carboxylates—particularly lactate, 3‐hydroxybutyrate, and butyrate—linked to metabolic and ...
Casper Homilius, Jacob M. Seefeldt, Jakob Hansen, Roni Nielsen, Frank V. de Paoli, Ebbe Boedtkjer   +5 more
wiley   +1 more source

Damage-associated molecular patterns as a mechanism of sevoflurane-induced neuroinflammation in neonatal rodents [PDF]

Korean Journal of Anesthesiology
Background General anesthesia is inevitable for pediatric patients undergoing surgery, though volatile anesthetic agents may cause neuroinflammation and neurodevelopmental impairment; however, the underlying pathophysiology remains unclear.
Young-Eun Joe, Ji Hae Jun, Ju Eun Oh, Jeong-Rim Lee   +3 more
doaj   +1 more source

Peri‐anaesthetic complications in 1798 equids undergoing high‐field elective orthopaedic MRI at a tertiary referral hospital

Equine Veterinary Journal, Volume 57, Issue 3, Page 666-673, May 2025.
Abstract Background Antimicrobial prophylaxis for elective orthopaedic magnetic resonance imaging (MRI) in equids is a topic of debate among practitioners and can have negative detrimental effects on patients if used unnecessarily. Objectives To describe the complications with elective orthopaedic MRI of horses, mules, and donkeys under general ...
Heath Manning, Sarah Sampson
wiley   +1 more source

Sugammadex-Enhanced Neuronal Apoptosis following Neonatal Sevoflurane Exposure in Mice

Anesthesiology Research and Practice, 2016
In rodents, neonatal sevoflurane exposure induces neonatal apoptosis in the brain and results in learning deficits. Sugammadex is a new selective neuromuscular blockade (NMB) binding agent that anesthesiologists can use to achieve immediate reversal of ...
Maiko Satomoto, Zhongliang Sun, Yushi U. Adachi, Koshi Makita   +3 more
doaj   +1 more source