Results 31 to 40 of about 4,240,671 (271)

Sex-biased gene expression and gene-regulatory networks of sex-biased adverse event drug targets and drug metabolism genes. [PDF]

BMC Pharmacol Toxicol, 2023
Abstract Background Previous pharmacovigilance studies and a retroactive review of cancer clinical trial studies identified that women were more likely to experience drug adverse events (i.e., any unintended effects of medication), and men were more likely to experience adverse events that resulted ...
Fisher JL, Clark AD, Jones EF, Lasseigne BN.   +3 more
europepmc   +4 more sources

Impact of 3D genome organization, guided by cohesin and CTCF looping, on sex-biased chromatin interactions and gene expression in mouse liver

Epigenetics & Chromatin, 2020
Several thousand sex-differential distal enhancers have been identified in mouse liver; however, their links to sex-biased genes and the impact of any sex-differences in nuclear organization and chromatin interactions are unknown. To address these issues,
Bryan J. Matthews, David J. Waxman
doaj   +1 more source

Sex-biased Gene Expression Underlies Immune Dysfunction in Asthma. [PDF]

Am J Respir Cell Mol Biol
Abstract Asthma prevalence and severity differs between male and female individuals across the lifespan. Prepubescent boys are more likely to experience asthma, but girls are disproportionately affected after puberty, with greater symptom burden and decreased type 2 inflammation.
Kay S, Rajeevan H, Son M, Kwah J, Ramirez M, Liu Y, Wang Z, Yan X, Nino G, Britto C, Chupp G, Gomez JL.   +11 more
europepmc   +3 more sources

Relationship between sex biases in gene expression and sex biases in autism and Alzheimer’s disease

, 2023
Abstract Sex differences in the brain may play an important role in sex-differential prevalence of neuropsychiatric conditions. In order to understand the transcriptional basis of sex differences, we analyzed multiple, large-scale, human postmortem brain RNA-seq datasets using both within-region and pan-regional frameworks.
Fass, Stuart B., Mulvey, Bernard, Yang, Wei, Selmanovic, Din, Chaturvedi, Sneha, Tycksen, Eric, Weiss, Lauren A., Dougherty, Joseph D.   +7 more
openaire   +2 more sources

Are sex-biased genes more dispensable? [PDF]

Biology Letters, 2009
Many genes show different expression levels in males and females, and these form the basis of sexually dimorphic phenotypes. Sex-biased genes experience accelerated rates of protein evolution, which has been attributed to sexual selection. However, it is possible that the increased rates of molecular evolution, and more importantly the sex-biased gene ...
Judith E, Mank, Hans, Ellegren
openaire   +2 more sources

Analysis of sex-biased gene expression in a Eurasian admixed population. [PDF]

Brief Bioinform
Abstract Sex-biased gene expression differs across human populations; however, the underlying genetic basis and molecular mechanisms remain largely unknown. Here, we explore the influence of ancestry on sex differences in the human transcriptome and its genetic effects on a Eurasian admixed population: Uyghurs living in Xinjiang (XJU ...
Cheng S, Ning Z, Huang K, Yuan Y, Tan X, Pan Y, Zhang R, Tian L, Lu Y, Wang X, Lu D, Yang Y, Guan Y, Mamatyusupu D, Xu S.   +14 more
europepmc   +3 more sources

Evolutionary Dynamics of Sex-Biased Genes in a Hermaphrodite Fungus [PDF]

Molecular Biology and Evolution, 2013
Differential gene expression is believed to largely explain sexually dichotomous phenotypes. This phenomenon is especially significant in hermaphrodites, in which male and female sexual tissues have identical genotypes. Sex differences in transcription have been linked to molecular evolution: genes with higher expression in male compared with female ...
Carrie A, Whittle, Hanna, Johannesson
openaire   +2 more sources

The unique genomic properties of sex-biased genes: Insights from avian microarray data

BMC Genomics, 2008
Background In order to develop a framework for the analysis of sex-biased genes, we present a characterization of microarray data comparing male and female gene expression in 18 day chicken embryos for brain, gonad, and heart tissue.
Webster Matthew T, Hultin-Rosenberg Lina, Mank Judith E, Ellegren Hans   +3 more
doaj   +1 more source

Sex-Biased Gene Expression and Evolution in the Cerebrum and Syrinx of Chinese Hwamei (Garrulax canorus). [PDF]

Genes (Basel), 2021
It is common that males and females display sexual dimorphisms, which usually result from sex-biased gene expression. Chinese hwamei (Garrulax canorus) is a good model for studying sex-biased gene expression because the song between the sexes is quite ...
Jiang H, Lin JQ, Sun L, Xu YC, Fang SG.
europepmc   +2 more sources

Widespread sex differences in gene expression and splicing in the adult human brain. [PDF]

, 2013
There is strong evidence to show that men and women differ in terms of neurodevelopment, neurochemistry and susceptibility to neurodegenerative and neuropsychiatric disease. The molecular basis of these differences remains unclear. Progress in this field
Ramasamy, Adaikalavan, Ryten, Mina, Ramasamy, A, Smith, C, Ryten, M, Trabzuni, D, Walker, R, Smith, Colin, Smith, C; id_orcid, Trabzuni, Daniah, Imran, S, Weale, M, Hardy, John, ?, ?, Weale, Michael E, Hardy, J, North American Brain Expression Consortium, Weale, ME, Imran, Sabaena, Walker, Robert   +19 more
core   +1 more source