Results 91 to 100 of about 6,189,888 (256)

Sex-biased gene expression across tissues reveals unexpected differentiation in the gills of the threespine stickleback

Peer Community Journal
Sexual dimorphism can evolve through sex-specific regulation of the same gene set. However, sex chromosomes can also facilitate this by directly linking gene expression to sex.
Sylvestre, Florent, Aubin-Horth, Nadia, Bernatchez, Louis   +2 more
doaj   +1 more source

Quality of sex-sampled and sex-biased lncRNAs at the Bmdsx gene locus.

, 2016
(A) Expression pattern of the W chromosome-specific gene, fem. (B) Sex-biased lncRNAs at the Bmdsx gene locus.
Yuqian Wu (549440), Chun Liu (47227), Ping Zhao (47228), Duolian Liu (846041), Qingyou Xia (47221), Renwen Long (711291), Tingcai Cheng (47225), Quan Zhang (168081)   +7 more
core   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Escape from X inactivation varies across genes and tissues and shapes sex-biased sex chromosome gene expression

BMC Genomics
Sex differences in human health and disease are shaped by complex interactions between hormones, environment, and genetic factors – including those associated with sex chromosomes.
Alex R. DeCasien
doaj   +1 more source

The developmental origins of sex-biased expression in cardiac development

Biology of Sex Differences, 2019
Background Expression patterns between males and females vary in every adult tissue, even in organs with no conspicuous dimorphisms such as the heart.
Daniel F. Deegan, Reza Karbalaei, Jozef Madzo, Rob J. Kulathinal, Nora Engel   +4 more
doaj   +1 more source

Transcriptome assemblies for studying sex-biased gene expression in the guppy, Poecilia reticulata [PDF]

, 2014
Background: Sexually dimorphic phenotypes are generally associated with differential gene expression between the sexes. The study of molecular evolution and genomic location of these differentially expressed, or sex-biased, genes is important for ...
Kottler, Verena, Zipprich, G., Weigel, D., Dreyer, Christine, Verena A Kottler, Künstner, Axel, Stefan R Henz, Christine Dreyer, Fraser, B., Bonnie A Fraser, Detlef Weigel, Henz, S., Fraser, Bonnie A., Eshita Sharma, Weigel, Detlef, Sharma, Eshita, Dreyer, C., Axel Künstner, Sharma, E., Kottler, V., Gideon Zipprich, Künstner, A., Henz, Stefan R.   +22 more
core   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Clinical and Modifiable Factors Associated With Disability and Relapse in MOGAD: A Multicentre Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Factors associated with relapse course and disability in myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD) remain incompletely understood. Objectives To identify clinical and modifiable factors associated with relapse and disability in MOGAD. Methods In this ambispective multicentre cohort study using data from
Yingtao Wang, Shaoxin Tao, Qiujia Wang, Xiaoyu Xu, Hui Yao, Zheng Liu, Dawei Li, Zhandong Qiu, Jinming Han, Jiangwei Xia, Qi Wang, Jun Sun, Kai Shao, Jiao Li, Shishuang Ruan, Yi Zhong, Jun Guo, Shougang Guo, Yue Huang, Guoliang Chai, Tao Jin, Hongyu Zhou, Junwei Hao, Yinan Zhao   +23 more
wiley   +1 more source

Evolutionary and biomedical implications of sex differences in the primate brain transcriptome

Cell Genomics
Summary: Humans exhibit sex differences in the prevalence of many neurodevelopmental disorders and neurodegenerative diseases. Here, we generated one of the largest multi-brain-region bulk transcriptional datasets for the rhesus macaque and characterized
Alex R. DeCasien, Kenneth L. Chiou, Camille Testard, Arianne Mercer, Josué E. Negrón-Del Valle, Samuel E. Bauman Surratt, Olga González, Michala K. Stock, Angelina V. Ruiz-Lambides, Melween I. Martínez, Susan C. Antón, Christopher S. Walker, Jérôme Sallet, Melissa A. Wilson, Lauren J.N. Brent, Michael J. Montague, Chet C. Sherwood, Michael L. Platt, James P. Higham, Noah Snyder-Mackler   +19 more
doaj   +1 more source

Sex-biased gene expression and sexual conflict throughout development

, 2014
Sex-biased gene expression is likely to account for most sexually dimorphic traits because males and females share much of their genome. When fitness optima differ between sexes for a shared trait, sexual dimorphism can allow each sex to express their ...
Fiona C Ingleby (5306140), Ted Morrow (4463680), Ilona Flis (3259983)   +2 more
core