Results 81 to 90 of about 6,189,888 (256)

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

The genetic influence of sex on gene expression for blood in pigs

BMC Genomics
Background Pigs are one of the most important farm animals in the agrifood industry. Many complex traits and patterns of gene expression exhibit sexual dimorphisms in pigs. However, the impact of sex on gene expression remains poorly understood.
Qing Lin, Junxiong Huang, Tianru Zhou, Teddy Tinashe Chitotombe, Jinyan Teng, Jiaqi Li   +5 more
doaj   +1 more source

Clinical Impact of NOTCH3 Variant Location After First Stroke in CADASIL

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Despite its monogenic origin, Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy exhibits marked variability in clinical expression and severity. Variants in the NOTCH3 gene, within epidermal growth factor‐like repeat domains 1–6 or 7–34, are known to influence disease onset, but their impact ...
Léa Aguilhon, Hugues Chabriat, Dominique Hervé, Stéphanie Guey, Sophie Tezenas Du Montcel, Juliette Ortholand   +5 more
wiley   +1 more source

Disentangling the relationship between sex-biased gene expression and X-linkage [PDF]

Genome Research, 2012
X chromosomes are preferentially transmitted through females, which may favor the accumulation of X-linked alleles/genes with female-beneficial effects. Numerous studies have shown that genes with sex-biased expression are under- or over-represented on the X chromosomes of a wide variety of organisms.
Meisel, Richard P., Malone, John H., Clark, Andrew G.   +2 more
openaire   +2 more sources

Sex-biased gene expression on the avian Z chromosome: highly expressed genes show higher male-biased expression. [PDF]

PLoS ONE, 2012
Dosage compensation, the process whereby expression of sex-linked genes remains similar between sexes (despite heterogamety) and balanced with autosomal expression, was long believed to be essential.
Sara Naurin, Dennis Hasselquist, Staffan Bensch, Bengt Hansson   +3 more
doaj   +1 more source

Evaluation of Digital Technologies for Home‐Based Assessment in People With Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Digital technologies hold promise for transforming healthcare by enhancing personalized treatments and offer valuable opportunities to improve patient care. Here, we evaluated several novel, self‐administered, home‐based, digital endpoints for their association with corresponding conventional standard clinical measures (primary) in ...
Arne Mueller, Vanessa Vallejo, Mónica Povedano Panadés, Orla Hardiman, Véronique Danel‐Brunaud, Senda Ajroud‐Driss, Philippe Couratier, Jeremy Shefner, Anna Gokey, Mike DiCesare, Erin Lennox, Jens Praestgaard, Lucie Brujin, Peggy Allred, Ram Miller   +14 more
wiley   +1 more source

Survey of gene, lncRNA and transposon transcription patterns in four mouse organs highlights shared and organ-specific sex-biased regulation

Genome Biology
Background Sex-biased gene regulation is the basis of sexual dimorphism in phenotypes and has been studied across different cell types and different developmental stages.
Qinwei Kim-Wee Zhuang, Klara Bauermeister, Jose Hector Galvez, Najla Alogayil, Enkhjin Batdorj, Fernando Pardo Manuel de Villena, Teruko Taketo, Guillaume Bourque, Anna K. Naumova   +8 more
doaj   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

Sex‐biased gene expression in dioecious garden asparagus (Asparagus officinalis) [PDF]

New Phytologist, 2015
Summary Sex chromosomes have evolved independently in phylogenetically diverse flowering plant lineages. The genes governing sex determination in dioecious species remain unknown, but theory predicts that the linkage of genes influencing male and female function will spur the origin and early evolution of sex chromosomes. For example, in an XY system,
Harkess Alex, Mercati Francesco, Shan HongYan, Sunseri Francesco, Falavigna Agostino, LeebensMack Jim   +5 more
openaire   +3 more sources

Sex-biased expression of sex-linked transcripts in spiny frogs with homomorphic sex chromosomes

BMC Genomics
Background The accumulation of sexually antagonistic mutations on chromosomes has been favored in driving the evolution of sex chromosomes. However, empirical evidence has been limited to species with heteromorphic sex chromosomes, where the patterns of ...
Yu Xiao, Yun Xia, Xiaomao Zeng
doaj   +1 more source