Results 71 to 80 of about 2,299,084 (348)
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
Genomic evidence reveals three W-autosome fusions in Heliconius butterflies.
PLoS GeneticsSex chromosomes are evolutionarily labile in many animals and sometimes fuse with autosomes, creating so-called neo-sex chromosomes. Fusions between sex chromosomes and autosomes have been proposed to reduce sexual conflict and to promote adaptation and ...
Nicol Rueda-M +11 more
doaj +1 more source
BAZ1B is dispensable for H2AX phosphorylation on Tyrosine 142 during spermatogenesis
Biology Open, 2015 Meiosis is precisely regulated by the factors involved in DNA damage response in somatic cells. Among them, phosphorylation of H2AX on Serine 139 (γH2AX) is an essential signal for the silencing of unsynapsed sex chromosomes during male meiosis. However,
Tyler J. Broering +5 more
doaj +1 more source
A large pseudoautosomal region on the sex chromosomes of the frog Silurana tropicalis [PDF]
, 2013 Sex chromosome divergence has been documented across phylogenetically diverse species, with amphibians typically having cytologically nondiverged (“homomorphic”) sex chromosomes.
Bewick, A. +13 more
core +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Ecology and EvolutionAn advantage of sex chromosomes may be the potential to reduce sexual conflict because they provide a basis for selection to operate separately on females and males.
Anika Minovic, Masafumi Nozawa
doaj +1 more source
Kinetic activity of the sex chromosomes of Mormidea paupercula (Heteroptera: Pentatomidae)
European Journal of Entomology, 2010 In Mormidea paupercula (n = 6 + XY in males), the presence of a CMA3-bright band in the telomeric regions on both sex chromosomes allowed the analysis of the kinetic activity of the sex univalents and XY pseudobivalent at the first and second meiotic ...
Pablo Javier REBAGLIATI +1 more
doaj +1 more source
Nature Communications, 2021 During meiosis, sex chromosomes show silenced gene expression that is disrupted when translocated to autosomes. Here, the authors engineer C. elegans with bisected X chromosomes and see active transcription in gonads, indicating continuity of sex ...
Yisrael Rappaport +5 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Autosomal dominant progranulin (GRN) pathogenic variants are a genetic cause of frontotemporal lobar degeneration. Though clinical trials for GRN‐related therapies are underway, there is an unmet need for biomarkers that can predict symptom onset and track disease progression.
Taru M. Flagan +46 more
wiley +1 more source
Ever-young sex chromosomes in European tree frogs.
PLoS Biology, 2011 Non-recombining sex chromosomes are expected to undergo evolutionary decay, ending up genetically degenerated, as has happened in birds and mammals. Why are then sex chromosomes so often homomorphic in cold-blooded vertebrates?
Matthias Stöck +13 more
doaj +1 more source