Results 101 to 110 of about 1,582,592 (296)
Sex-biased transcriptome in in vitro produced bovine early embryos
Cell & BioscienceBackground Morphologic sex differences between males and females typically emerge after the primordial germ cell migration and gonad formation, although sex is determined at fertilization based on chromosome composition.
Meihong Shi +8 more
doaj +1 more source
Duplicated membrane estrogen receptors in the European sea bass (Dicentrarchus labrax): Phylogeny, expression and regulation throughout the reproductive cycle [PDF]
, 2018 The numerous estrogen functions reported across vertebrates have been classically explained by their binding to specific transcription factors, the nuclear estrogen receptors (ERs).
Alvarado, M. Victoria +5 more
core +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Sex-biased expression of sex-linked transcripts in spiny frogs with homomorphic sex chromosomes
BMC GenomicsBackground The accumulation of sexually antagonistic mutations on chromosomes has been favored in driving the evolution of sex chromosomes. However, empirical evidence has been limited to species with heteromorphic sex chromosomes, where the patterns of ...
Yu Xiao, Yun Xia, Xiaomao Zeng
doaj +1 more source
Royal Society Open ScienceSexual dimorphism, the divergence in morphological traits between males and females of the same species, is often accompanied by sex-biased gene expression.
Freya A. Pappert +3 more
doaj +1 more source
Selection shapes turnover and magnitude of sex-biased expression in Drosophila gonads
BMC Evolutionary Biology, 2019 Background Sex-biased gene expression is thought to drive the phenotypic differences in males and females in metazoans. Drosophila has served as a primary model for studying male-female differences in gene expression, and its effects on protein sequence ...
Carrie A. Whittle, Cassandra G. Extavour
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Expression profiles for six zebrafish genes during gonadal sex differentiation
Reproductive Biology and Endocrinology, 2008 Background The mechanism of sex determination in zebrafish is largely unknown and neither sex chromosomes nor a sex-determining gene have been identified.
Rasmussen Lene J +4 more
doaj +1 more source
NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source
Structural and evolutionary features of red algal UV sex chromosomes
Genome BiologyBackground Sex chromosomes in red algae have remained relatively understudied, despite their fundamental role in understanding the evolution of sex determination across eukaryotes.
Agnieszka P. Lipinska +17 more
doaj +1 more source