Results 91 to 100 of about 5,225,716 (254)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Sex-biased transcriptome in in vitro produced bovine early embryos

Cell & Bioscience
Background Morphologic sex differences between males and females typically emerge after the primordial germ cell migration and gonad formation, although sex is determined at fertilization based on chromosome composition.
Meihong Shi, Guangsheng Li, Hannah Marie Araujo, Angie S. Lee, Jingzhi Zhang, Yoke Lee Lee, IISAGE Consortium, Soon Hon Cheong, Jingyue Ellie Duan   +8 more
doaj   +1 more source

Identification of General Patterns of Sex-Biased Expression in Daphnia, a Genus with Environmental Sex Determination

G3: Genes, Genomes, Genetics, 2018
Daphnia reproduce by cyclic-parthenogenesis, where phases of asexual reproduction are intermitted by sexual production of diapause stages. This life cycle, together with environmental sex determination, allow the comparison of gene expression between ...
Cécile Molinier, Céline M.O. Reisser, Peter Fields, Adeline Ségard, Yan Galimov, Christoph R. Haag   +5 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Navigating sex and sex roles: deciphering sex-biased gene expression in a species with sex-role reversal (Syngnathus typhle)

Royal Society Open Science
Sexual dimorphism, the divergence in morphological traits between males and females of the same species, is often accompanied by sex-biased gene expression.
Freya A. Pappert, Arseny Dubin, Guillermo G. Torres, Olivia Roth   +3 more
doaj   +1 more source

Sex ratios in the rodent malaria parasite, Plasmodium chabaudi [PDF]

, 2003
The sex ratios of malaria and related Apicomplexan parasites play a major role in transmission success. Here, we address 2 fundamental issues in the sex ratios of the rodent malaria parasite, Plasmodium chabaudi.
West, S A, Read, A F, Duncan, A B, West, Stuart A, Reece, S E, Duncan, Alison B, Read, Andrew F   +6 more
core   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Sex-biased expression of sex-linked transcripts in spiny frogs with homomorphic sex chromosomes

BMC Genomics
Background The accumulation of sexually antagonistic mutations on chromosomes has been favored in driving the evolution of sex chromosomes. However, empirical evidence has been limited to species with heteromorphic sex chromosomes, where the patterns of ...
Yu Xiao, Yun Xia, Xiaomao Zeng
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Structural and evolutionary features of red algal UV sex chromosomes

Genome Biology
Background Sex chromosomes in red algae have remained relatively understudied, despite their fundamental role in understanding the evolution of sex determination across eukaryotes.
Agnieszka P. Lipinska, Guillaume Cossard, Paul Epperlein, Tobias Woertwein, Cecile Molinier, Olivier Godfroy, Sabrina Carli, Ligia Ayres-Ostrock, Emma Lavaut, Fabiana Marchi, Stephane Mauger, Christophe Destombe, Mariana C. Oliveira, Estela M. Plastino, Stacy A. Krueger-Hadfield, Marie-Laure Guillemin, Myriam Valero, Susana M. Coelho   +17 more
doaj   +1 more source