Results 71 to 80 of about 665,360 (253)

Relationship between sex biases in gene expression and sex biases in autism and Alzheimer’s disease

Biology of Sex Differences
Background Sex differences in the brain may play an important role in sex-differential prevalence of neuropsychiatric conditions. Methods In order to understand the transcriptional basis of sex differences, we analyzed multiple, large-scale, human ...
Stuart B. Fass, Bernard Mulvey, Rebecca Chase, Wei Yang, Din Selmanovic, Sneha M. Chaturvedi, Eric Tycksen, Lauren A. Weiss, Joseph D. Dougherty   +8 more
doaj   +1 more source

Selection shapes turnover and magnitude of sex-biased expression in Drosophila gonads

BMC Evolutionary Biology, 2019
Background Sex-biased gene expression is thought to drive the phenotypic differences in males and females in metazoans. Drosophila has served as a primary model for studying male-female differences in gene expression, and its effects on protein sequence ...
Carrie A. Whittle, Cassandra G. Extavour
doaj   +1 more source

Expression Divergence in Response to Sex-biased Selection [PDF]

Molecular Biology and Evolution
Abstract It remains debated whether greater degrees of sexual dimorphism would evolve if not for intersexual genetic constraints. Here, we used experimental evolution to partially break the intersexual genetic constraint in Drosophila melanogaster to investigate the effects of a shared gene pool on the evolution of sexual dimorphism ...
Karl Grieshop, Michelle J Liu, Ryan S Frost, Matthew P Lindsay, Malak Bayoumi, Martin I Brengdahl, Ruxandra I Molnar, Aneil F Agrawal   +7 more
openaire   +3 more sources

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Sex-biased transcriptome in in vitro produced bovine early embryos

Cell & Bioscience
Background Morphologic sex differences between males and females typically emerge after the primordial germ cell migration and gonad formation, although sex is determined at fertilization based on chromosome composition.
Meihong Shi, Guangsheng Li, Hannah Marie Araujo, Angie S. Lee, Jingzhi Zhang, Yoke Lee Lee, IISAGE Consortium, Soon Hon Cheong, Jingyue Ellie Duan   +8 more
doaj   +1 more source

Sex determination and gender expression: Reproductive investment in snails [PDF]

Molecular Reproduction and Development, 2017
SUMMARYSex determination is generally seen as an issue of importance for separate‐sexed organisms; however, when considering other sexual systems, such as hermaphroditism, sex allocation is a less‐binary form of sex determination. As illustrated here, with examples from molluscs, this different vantage point can offer important evolutionary insights ...
openaire   +3 more sources

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Navigating sex and sex roles: deciphering sex-biased gene expression in a species with sex-role reversal (Syngnathus typhle)

Royal Society Open Science
Sexual dimorphism, the divergence in morphological traits between males and females of the same species, is often accompanied by sex-biased gene expression.
Freya A. Pappert, Arseny Dubin, Guillermo G. Torres, Olivia Roth   +3 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Expression profiles for six zebrafish genes during gonadal sex differentiation

Reproductive Biology and Endocrinology, 2008
Background The mechanism of sex determination in zebrafish is largely unknown and neither sex chromosomes nor a sex-determining gene have been identified.
Rasmussen Lene J, Andersen Ole, Morthorst Jane E, Jørgensen Anne, Bjerregaard Poul   +4 more
doaj   +1 more source