Results 91 to 100 of about 20,923 (214)

Mapping Steroidogenic Perturbations Under Endocrine Disruptor Mixtures Across Demographic Subgroups: Structural and Metabolomic Insights

Advanced Science, Volume 13, Issue 46, 17 August 2026.
Population‐scale EDC–hormone association mapping among 4255 participants across demographic subgroups identifies phthalate metabolites as the most consistent signals associated with lower testosterone‐related markers in males. Integrative mechanistic validation prioritizes MCPP as a key phthalate metabolite linked to CYP17A1‐centered disruption of ...
Yanling Chen, Lei Huang, Yingtong Jiang, Guohong Zhao, Mengyuan Zhu, Xiulian Lu, Lang Lang, Akinpelumi Oluwatobiloba Esther, Longhao Fan, Yuqi Jiang, Chang Sun, Xiaoling Zhang, Kun Zhou, Xiaoming Ji, Minjian Chen   +14 more
wiley   +1 more source

Circulating Sex Hormone Levels and Survival in Men With Esophageal Squamous Cell Carcinoma

Cancer Medicine, Volume 15, Issue 8, August 2026.
ABSTRACT Background Men with esophageal squamous cell carcinoma (ESCC) have worse survival than women, a disparity in which sex hormones may play a role. Yet, whether circulating sex hormone levels are associated with survival in ESCC remains largely unexplored.
Zhiqiang Liu, Zhifeng Lin, Jesper Lagergren, Hejie Wang, Xiaodan Mao, Mei Ma, Zhijian Hu, Shao‐Hua Xie   +7 more
wiley   +1 more source

Impact of Metformin Use on Clinical and Pathological Outcomes in Breast Cancer Patients With Type 2 Diabetes

Cancer Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background Breast cancer is the most common malignancy in women, and its incidence is increasing worldwide. Type 2 diabetes mellitus (T2DM) is a significant comorbidity in patients with breast cancer that negatively affects prognosis. Metformin, a first‐line antidiabetic drug, has been suggested to possess antineoplastic properties. This study
Ensiyeh Bahadoran, Monir Mirzadeh, Mohsen Jafari, Yazdan Zafari, Sahar Moghbelinejad   +4 more
wiley   +1 more source

Study on the Effects and Mechanisms of Sea Buckthorn Fruit Pulp in Improving Polycystic Ovary Syndrome

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
Sea buckthorn pulp improves metabolic and reproductive dysfunction in a letrozole‐induced PCOS mouse model and is associated with modulation of the PI3K/AKT/mTOR signaling pathway. ABSTRACT Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder characterized by ovarian dysfunction, hyperandrogenism, and insulin resistance.
Han Xiaoya, Yang Yuanyuan, Peng Qingjie, Chen Xiaojiang, Ma Cunling, Li Na, Tian Xiaofan, Wu Xin, Liu Hetao, He Rui   +9 more
wiley   +1 more source

Association of Testosterone With Lean Soft Tissue and Handgrip Strength Across Middle‐Aged Men

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background Testosterone declines by 0.4%–2% annually after the age of 30 and is potentially linked with muscle mass and strength. This study examined how testosterone levels are associated with handgrip strength (HGS) and appendicular lean soft tissue index (ALSTI) in men aged 40–49 and 50–59 years.
Konstantinos Prokopidis, Stefano Cacciatore, Joseph McLean, Paolo Piaggi, Carla M. Prado, John A. Batsis, Mathias Schlögl   +6 more
wiley   +1 more source

Maize Biofortification Approaches for Fighting Malnutrition in Sub‐Saharan Africa

Plant-Environment Interactions, Volume 7, Issue 4, August 2026.
ABSTRACT Maize is a staple food in sub‐Saharan Africa (SSA); however, commonly used maize varieties are deficient in essential nutrients, including lysine, tryptophan, vitamin A, and minerals such as iron (Fe) and zinc (Zn). As a result, millions of people in this region suffer from one or more nutrient deficiencies that commonly lead to malnutrition ...
Bitew Tilahun Engida, Tesfaye Walle Mekonnen, Maryke Labuschagne   +2 more
wiley   +1 more source

Sex Hormones and the Risk of Nasal Polyps: A Two‐Sample Mendelian Randomization Study

World Journal of Otorhinolaryngology - Head and Neck Surgery, Volume 12, Issue 4, Page 424-431, August 2026.
ABSTRACT Objective The pathophysiological roles of sex hormones in airway inflammation have drawn much attention recently. We aimed to explore the causal effect of sex hormones on chronic rhinosinusitis (CRS) and nasal polyps (NP) via a Mendelian randomization (MR) study.
Ying Zhu, Jia‐Yao Zhou, Shi‐Yao Zhang, Ru Tang, Chun‐Yu Luo, Yue‐Long Gu, Zhi‐Peng Li, Wei‐Tian Zhang   +7 more
wiley   +1 more source

Sex hormone-binding globulin impedes hepatocellular carcinoma growth via MERTK regulation

Genes and Diseases, 2022
Sang R. Lee, Eui-Ju Hong
doaj   +1 more source

Insulin Resistance Emerges Early After Glucocorticoid Treatment in Adult Patients With 21‐Hydroxylase Deficiency

Journal of Diabetes, Volume 18, Issue 8, August 2026.
In adults with 21‐hydroxylase deficiency, ongoing glucocorticoid therapy, especially dexamethasone, was the main risk factor for insulin resistance. New‐onset insulin resistance emerged early, highlighting the need for metabolic monitoring within the first 1–2 years of treatment. ABSTRACT Background Metabolic disorders, particularly insulin resistance (
Chenchen Dong, Wencui Wang, Sichang Zheng, Lingxin Deng, Rulai Han, Weiqing Wang, Guang Ning, Shouyue Sun, Lei Ye   +8 more
wiley   +1 more source

Metabolic Phenotype Predicts Biochemical Response to Inositol Supplementation in Polycystic Ovary Syndrome: A Systematic Review and Meta‐Analysis

Clinical Endocrinology, Volume 105, Issue 2, Page 237-244, August 2026.
ABSTRACT Objective To evaluate the effect of inositol supplementation on biochemical hyperandrogenism in women with polycystic ovary syndrome (PCOS) and to explore whether metabolic phenotype modifies the endocrine response. Design Systematic review and meta‐analysis of randomized controlled trials conducted in accordance with PRISMA guidelines ...
Daniele Tienforti, Gennaro Puocci, Claudia Venditti, Valentina Gizzi, Carlo Pisanò, Elisa Cocci, Elisabetta Perfetto, Francesco D'Alessandro, Luca Spagnolo, Marco Giorgio Baroni, Arcangelo Barbonetti   +10 more
wiley   +1 more source