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Are Corticosteroid‐Binding Globulin and Sex Hormone‐Binding Globulin Hormones?a

Annals of the New York Academy of Sciences, 1988
Because it no longer seemed reasonable to us that the sole function of the steroid-binding proteins in plasma was to serve as a buffer reservoir for steroid hormones, we conducted experiments which sought out other possibilities. Both CBG and SHBG bind to cell membranes, and this interaction partakes of the general characteristics of peptide hormone ...
W, Rosner   +4 more
openaire   +2 more sources

Differential effects of exercise on sex hormone-binding globulin and non-sex hormone-binding globulin-bound testosterone

European Journal of Applied Physiology and Occupational Physiology, 1996
The response of total testosterone (T), free testosterone (fT), sex hormone-binding globulin (SHBG) and non-SHBG-bound testosterone (NST) to the same exercise protocol was evaluated in two different experiments on long distance runners. The first experiment was performed in the morning at 0900 hours with nine athletes, while the second was carried out ...
Bonifazi M., Lupo C.
openaire   +4 more sources

Free estradiol and sex hormone-binding globulin

Steroids, 2015
SHBG is a plasma protein that participates in the regulation of free estradiol and free testosterone in plasma. We discuss the concept of the nature of a free estradiol and how best to ascertain its value. It can be measured or calculated; the ways in which this can be done are explored along with the advantages and disadvantages of each.
openaire   +2 more sources

Plasma Variation of Corticosteroid-binding Globulin and Sex Hormone-binding Globulin

Hormone and Metabolic Research, 2006
Sex hormone-binding globulin (SHBG) and corticosteroid-binding globulin (CBG) circulate in plasma and bind their cognate ligands with high affinity, offering a steroid delivery system to target tissues by a variety of mechanisms. Analysis of these steroid-binding proteins is gaining importance in the clinical setting, although more information is ...
J G, Lewis   +6 more
openaire   +2 more sources

SEX HORMONE BINDING GLOBULIN IN WOMEN WITH ANOREXIA NERVOSA

Clinical Endocrinology, 1986
SUMMARYIn 29 women with anorexia nervosa, on a blood sample withdrawn at 0900 h before and during weight gain, the binding parameters of serum sex hormone binding globulin (SHBG) were measured by a solid phase method and the levels of testosterone, oestradiol and thyroid hormones were measured by radioimmunoassay.
B, Estour   +5 more
openaire   +2 more sources

Sex hormone-binding globulin and female reproductive function

The Journal of Steroid Biochemistry and Molecular Biology, 1995
Although sex steroids have long been known to influence serum concentrations of SHBG, it is now recognized that nutritional factors may be more important in the regulation of SHBG in women. Thus, SHBG concentrations are negatively correlated with body mass index (BMI) and, more particularly, to indices of central adiposity.
N, Botwood   +4 more
openaire   +2 more sources

Sex hormone-binding globulin in congenital adrenal hyperplasia

hmbci, 2009
Abstract Background : Sex hormone-binding globulin biosynthesis is influenced by three hormonal systems: gonadal, insular and thyroid. Congenital adrenal hyperplasia is characterized by overproduction of adrenal androgens associated with impaired insulin sensitivity, hyperinsulinemia and often ...
Ludmila, Zamrazilová   +4 more
openaire   +2 more sources

Purification and characterization of human sex hormone binding globulin

Journal of Steroid Biochemistry, 1979
Abstract Sex hormone binding globulin (SHBG) was isolated from post-partum plasma in a three stage procedure involving affinity chromatography on androstanediol-3-hemisuccinate aminohexyl Sepharose 4B followed by affinity chromatography using Cibacron Blue F3G-A-Sepharose 4B and finally gel filtration on Sephadex G-150.
M J, Iqbal, M W, Johnson
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Variations of Sex Hormone-Binding Globulin in Thyroid Dysfunction

Thyroid, 1999
With the aim of understanding the variations of the levels of sex hormone-binding globulin (SHBG) in thyroid dysfunction, we studied the influence of factors that also modify SHBG, such as menopausal status, age, and body mass index (BMI) in women with hypothyroidism and hyperthyroidism, both overt and subclinical. Statistical analysis was performed by
G, Brenta   +6 more
openaire   +2 more sources

Sex hormone-binding globulin—still many questions

Scandinavian Journal of Clinical and Laboratory Investigation, 1985
(1985). Sex hormone-binding globulin—still many questions. Scandinavian Journal of Clinical and Laboratory Investigation: Vol. 45, No. 1, pp. 1-6.
G, Lindstedt   +3 more
openaire   +2 more sources

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