Results 111 to 120 of about 366,885 (264)

Acute cardiovascular effects associated with the use of prescription medications: A Danish nationwide screening study

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim This study aims to conduct a hypothesis‐generating screening for acute cardiovascular effects of prescription medications. Methods This Danish nationwide screening study was conducted among incident cases of cardiovascular diseases, including myocardial infarction (MI), ischemic stroke (IS), heart failure (HF), venous thromboembolism (VTE),
Saad Hanif Abbasi, Lars Christian Lund, Jesper Hallas, Martin Thomsen Ernst, Anton Pottegård   +4 more
wiley   +1 more source

First‐in‐human safety, tolerability, pharmacokinetics and pilot food‐effect study of the candidate antimalarial compound MMV367

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim To evaluate the safety, tolerability and pharmacokinetics in healthy participants of orally administered MMV367 (GSK3772701), a novel antimalarial interfering with Plasmodium falciparum acyl coenzyme A synthetase 10/11 function. Methods This first‐in‐human study enrolled 47 healthy male and female participants.
Andrea Kuemmerle, Nand Singh, Denis Gossen, Annick Janin, Raman Sharma, Anthony Cahn, Rachel A. Gibson, Somasekhara R. Menakuru, Erin Lambourne, Tom Dove, Francisco‐Javier Gamo, Laura Sanz, Benoit Bestgen, Stephan Chalon   +13 more
wiley   +1 more source

Utilization and expenditure on medicines for the management of osteoporosis in Ireland: A repeated cross‐sectional study

British Journal of Clinical Pharmacology, EarlyView.
Aim Osteoporosis is a prevalent skeletal disease characterized by low bone mass and increased fracture risk. Management of osteoporosis typically involves antiresorptive and anabolic therapies, which are reimbursed in Ireland through various drug schemes.
Amelia Smith, Lisa Kelly, Claire Gorry, Bernard Duggan, Michael Barry   +4 more
wiley   +1 more source

Pharmacokinetics of betamethasone in pre‐eclampsia: An in vivo and ex vivo study

British Journal of Clinical Pharmacology, EarlyView.
Aims To enhance understanding of betamethasone and its metabolites' pharmacokinetics in pregnancy, specifically early‐onset pre‐eclampsia, through a population pharmacokinetic model. Additionally, to investigate the placental metabolism and transfer of betamethasone and its main metabolites.
Sam Schoenmakers, Letao Li, Anna C. M. Kluivers, Michelle Broekhuizen, Madhavi S. Harhangi, A. H. Jan Danser, Irwin Reiss, Karel Allegaert, Sjoerd A. A. van den Berg, Bertrand D. van Zelst, Ron H. N. van Schaik, Philip L. J. DeKoninck, Emma Ronde, Sebastiaan D. T. Sassen, Sinno H. P. Simons, Birgit C. P. Koch   +15 more
wiley   +1 more source

Sex Hormones and Heart Failure Risk. [PDF]

JACC Adv
Ebong IA, Appiah D, Mauricio R, Narang N, Honigberg MC, Ilonze OJ, Aggarwal NR, Zanni MV, Mohammed SF, Cho L, Michos ED, American College of Cardiology Cardiovascular Disease in Women Committee.   +11 more
europepmc   +1 more source

General practitioner consultation for postmenopausal bleeding after COVID‐19 vaccination—a self‐controlled cohort study

British Journal of Clinical Pharmacology, EarlyView.
Aims The incidence of postmenopausal bleeding (PMB) has been increasing over the past years. Little is known about the risk of PMB after COVID‐19 vaccination. Our study aimed to investigate this based on routine general practitioner (GP) healthcare data from the Netherlands.
Rana Jajou, Eugène P. van Puijenbroek, Renee Veldkamp, Jetty A. Overbeek, Florence P. A. M. van Hunsel, Agnes C. Kant   +5 more
wiley   +1 more source

Effects of Lead Exposure on 1573 Male Workers' Sex Hormones in China. [PDF]

Toxics
Wang P, Wu Z, Li J, Li Y, Wang X, Ma M, Wei W, Wang Y, Liu Y, Sun Y, Tao L, Yang Y, Zhou Z, Ren J, Cao J, Zhang G.   +15 more
europepmc   +1 more source

Male Sex Hormones [PDF]

BMJ, 1960
openaire   +3 more sources

Analysis of 4616 clinical trial initial submissions received by the Medicines and Healthcare products Regulatory Agency between February 2019 and October 2023

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to analyse clinical trial initial submissions received by the MHRA between February 2019 and October 2023. Methods Data on submissions were extracted from the clinical trials unit data bank. The primary end‐point was the type of clinical trial initial submissions.
Andrea Manfrin, Kingyin Lee, James Pound, Munir Pirmohamed, June Raine   +4 more
wiley   +1 more source

The Role of Sex Hormones in Cartilaginous Tissues: A Scoping Review. [PDF]

JOR Spine
Hutchinson JL, Hutchinson AJ, Feng J, Séguin CA.   +3 more
europepmc   +1 more source