Results 101 to 110 of about 209,673 (304)
Sex‐Specific Regulation of Glycemic Homeostasis by Theabrownin from Pu‐erh Tea
Advanced Science, EarlyView.Pu‐erh tea's key component, theabrownin (TB), lowers blood glucose in a sex‐specific manner. In females, estrogen boosts intestinal MUC2 production, which dramatically enhances TB's ability to inhibit the carbohydrate‐digesting enzyme α‐glucosidase.Yang Li, Junliang Kuang, Dan Zheng, Jieyi Wang, Kun Ge, Chun Qu, Xiaojiao Zheng, Zhenxing Ren, Fengjie Huang, Mingliang Zhao, Yimin Sun, Huiheng Zhang, Keke Ding, Xixi Xia, Yajun Tang, Lu Liu, Jian Zhou, Fei Gao, Xiaohui Ma, Yongquan Xu, Guoxiang Xie, Aihua Zhao, Wei Jia +22 morewiley +1 more sourceInfluence of sex hormones on the periodontium [PDF]
, 2003 Objectives : Sex hormones have long been considered to play an influential role on periodontal tissues, bone turnover rate, wound healing and periodontal disease progression.Al-Shammari, Khalaf, Gapski, Ricardo, Wang, Hom-Lay, Mascarenhas, Paulo +3 morecore +1 more sourceFunctional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery
Advanced Science, EarlyView.Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances Eliska Kuchovska, Kristina Bartmann, Georgea Raad, Mats Schade, Luiz Ladeira, Arif Dönmez, Jördis Klose, Nicolai Görts, Denis Polozij, Lynn‐Christin Saborowski, Farina Bendt, Bernard Staumont, Liesbet Geris, Katharina Koch, Ellen Fritsche +14 morewiley +1 more sourceA Genome-Wide Association Meta-Analysis of Circulating Sex Hormone-Binding Globulin Reveals Multiple Loci Implicated in Sex Steroid Hormone Regulation [PDF]
, 2012 Sex hormone-binding globulin (SHBG) is a glycoprotein responsible for the transport and biologic availability of sex steroid hormones, primarily testosterone and estradiol.Frank H de Jong, Lyytikäinen LP, Vasan, Ramachandran S, Wichmann HE, Mei, Yong, Dhananjay Vaidya, Prescott, Jennifer, Douglas P. Kiel (150100), Shalender Bhasin (112670), Papunen, Laure Morin, Murray, A, McCarthy, Mark I, Stephen J. Chanock (14311), Anneli Pouta, Fornage, Myriam, van der Schouw, Y.T., Lehtimäki Terho, Biffar Reiner, Mangino, M., Schwartz SM, Bandinelli, S, Mellström, D, Rexrode, Kathryn, Ruokonen, A., Cummings S, Stolk Lisette, Stephen M Schwartz, David Karasik, Martikainen Hannu, Miljkovic, I, Mangino Massimo, Coviello, A.D., Reiner, A.P., Cox, DG, Daniel Mirel (150151), Murabito Joanne M., Murabito JM, Uitterlinden, André G, Perry, J.R., Keildson, S., Hunter David J., Ouyang, Pamela, Järvelin, MR, van Gils, van, Marcello Maggio, Ljunggren, O. (Östen), Frayling, Timothy M., Marc J Gunter, John-Olov Jansson, Hofman, A., Koster, A, Harris, T.B. (Tamara), Lunetta, KL, Johnson, A.D. (Andrew), Brabant, G, Onland-Moret, N. Charlotte, Franks, S. (Steve), Wichmann, H-E, Pamela Ouyang, Miljkovic I, Rivadeneira, F, Bhasin, S, Murabito, J. (Joanne), Murray A, Tworoger, Shelley, Prescott J, Prokopenko I, Vaidya, Dhananjay, Gils, C.H. (Carla) van, Chen Y, Raffel, L, Chen B, Prescott, J., Kiel Douglas P., Stöckl, Doris, Hofman Albert, Nelson S, Järvelin Marjo-Riitta, Kurt Lohman, McCarthy, MI, Kähönen Mika, McCarthy Mark I., Kähönen, M, Illig T, Hannu Martikainen, Kurt Lohman (110218), Biffar, R, Ohlsson, C, Thomas Illig, Johannes Kettunen (120333), Raitakari, Olli T., Siscovick D, Homuth, G. (Georg), Johannes Kettunen, Ruokonen, A. (Aimo), Mellström D, Georg Brabant, David Karasik (150081), Perry JR, Cox, David G., Kähönen, M., Homuth G, Markus, Marcello RP, Reincke, M., van der Schouw, YT, Wellons Melissa, Dan Mellström, Fernando Rivadeneira, Jingmin Liu (150110), Tamara B. Harris (110195), Mangino, M, Guangju Zhai (110167), Rexrode, K., Kraft Peter, van der Schouw YT, Aimo Ruokonen (116631), Jansson JO, Tworoger Shelley, Jansson, JO, Martin Reincke, Ohlsson, C. (Claes), Chanock, S.J., Peeters, Petra H M, Reiner, Alex P, Chen, Yuhui, MAGGIO, Marcello Giuseppe, Järvelin, Marjo-Riitta, Illig, T., Tim D Spector, Garcia Melissa, Murabito, Joanne M., Stolk, L., Hunter, DJ, Ramachandran S Vasan, De Vivo, Immaculata, Östen Ljunggren (150116), Lohman Kurt, Harris TB, Marcello R. P. Markus (150133), Stefania Bandinelli (150002), Peeters, Petra H. M., Yong Mei Liu, Rexrode, K, Garcia, M., Lohman K, Tim D. Spector (108990), Melissa Garcia, Hofman A, Yuhui Chen, Wallaschofski, Henri, Mellström, Dan, Ruokonen, Aimo, Ferrucci Luigi, Brabant Georg, Vandenput L, Haring, R. (Robin), Reiner AP, Frayling, T.M. (Timothy), Zhuang, Wei Vivian, Wood, Andrew R, Uitterlinden, André G., Stephen M. Schwartz (38143), Kiel, Douglas P, Stöckl, D., Ruokonen Aimo, Perry, J.R.B. (John), Luigi Ferrucci (150038), Vasan, Ramachandran S., Anna-Liisa Hartikainen, Johnson AD, Vaidya Dhananjay, Leslie Raffel, Schwartz, Stephen M, Kiel, Douglas, Mattias Lorentzon, H.-Erich Wichmann (72009), Peeters, P.H., Lorentzon, Mattias,, Kiel, D.P., Coviello AD, Bhasin, S., Ouyang, P, Raitakari, Olli, Mellström, Dan,, Brabant G, Murabito, J.M., David J. Hunter (50227), Franks, S., Ruokonen, A, Petersen Ann-Kristin, Shelley Tworoger (150178), Myriam Fornage, Illig, Thomas, Rexrode, K. (Kathryn), Cummings, Steven, Pouta, A. (Anneli), Marcello R P Markus, Wei Vivian Zhuang, Jingmin Liu, De Vivo I, Ann-Kristin Petersen, Soranzo Nicole, Eriksson, Joel, Carla H. van Gils (150182), Koster Annemarie, Schwartz, Stephen M., Järvelin MR, Johnson, Andrew D., McCarthy, M.I. (Mark), Reiner Biffar, Aimo Ruokonen, Onland-Moret, NC, Schwartz, SM, Carla H van Gils, Stolk, L. (Lisette), Hankinson SE, Claes Ohlsson (1924), Coviello Andrea D., Onland-Moret, N.C. (Charlotte), Bidlingmaier, M., Lohman, Kurt, Tworoger, Shelley S., Liu YM, Martikainen, H, Zhai, G. (Guangju), Vandenput, L., Kathryn Rexrode, Kathryn L. Lunetta (149902), He C, Ljunggren, Östen, Markus, Marcello R. P., Alexander Teumer (112757), Doris Stöckl (150177), Sarah Keildson, Chen, Brian, Vandenput, Liesbeth,, Doris Stöckl, Biffar, R., Wichmann, H Erich, Wei Vivian Zhuang (149990), Hunter, D.J., Karasik D, Fornage Myriam, Teumer, A. (Alexander), Cox David G., Garcia, Melissa E, Johnson, A.D., Lyytikäinen, L.-P., Wallaschofski, H. (Henri), David J Hunter, Biffar R, Lyytikainen, L-P, Kettunen J, Siscovick David, Jennifer Prescott (76050), Rexrode K, Brian Chen, Markus, MR, Ljunggren Östen, Hankinson Susan E., Rivadeneira Fernando, Lunetta, Kathryn L, Hartikainen, AL, Franks, S, Leo-Pekka Lyytikäinen (144253), Viikari, Jorma S., Leslie Raffel (150165), Franks, Steve, Karlsson, M., Murray, J.C. (Jeffrey), Inga Prokopenko, Viikari J, Lorentzon, M. (Mattias), Georg Homuth (110202), Timothy M Frayling, Bhasin S, Petersen, A-K, Chanock, Stephen J., Mirel, Daniel, Eriksson, J., Lisette Stolk (149967), Guangju Zhai, Andrew D. Johnson (150072), Haring, Robin, Mirel Daniel, David Siscovick, Murray, A., Schwartz, S.M. (Stephen), Jarvelin, M.-R. (Marjo-Riitta), Raitakari, O., Keildson, S, Soranzo, N., Fornage M, Kähönen, M. (Mika), Pouta, A., Karasik, D. (David), He, Chunyan, Perry, JR, Daniel Mirel, Brabant, G., Wichmann, HE, Hunter DJ, Andrea D. Coviello (149867), Yvonne T. van der Schouw (50177), Fornage, M., Martin Bidlingmaier (150187), Viikari, J. (Jorma), van der Schouw Yvonne T., Lyytikäinen Leo-Pekka, Perry, John R.B., Wellons, M. (Melissa), N Charlotte Onland-Moret, Martin Bidlingmaier, Tworoger S, Murabito, JM, Raitakari Olli, Frayling, Timothy M, Teumer, Alexander, Leo-Pekka Lyytikäinen, Chen, BPC, Ramachandran S. Vasan (110476), Illig, T, Bandinelli, S. (Stefania), Spector Tim D., He, CY, Liu, Simin, Gunter Marc J., Vasan, RS, Steven Cummings, Wellons, M, Ljunggren, Ö, Prokopenko, I, Henri Wallaschofski, Mirel, D. (Daniel), Pouta, A, van der Schouw, Yvonne T., Nicole Soranzo (12361), Spector, T.D. (Timothy), Raitakari O, Mei, Y, Maggio, M., He, C. (Chunyan), He, C, Perry, JRB, Kraft, Peter, Onland Moret NC, Liu Jingmin, Karlsson Magnus, Soranzo, Nicole, Hofman, A. (Albert), Lehtimäki T, Viikari Jorma, Wood, A.R., Albert Hofman, Fornage, M, Peeters, Petra HM, Uitterlinden André G., Pouta Anneli, Morin Papunen, Laure, Zhuang, WV, Karasik, D., Siscovick, David S, Viikari, Jorma, Cummings Steven, Homuth Georg, Keildson, Sarah, Liesbeth Vandenput, Mirel, D., Liu, Jingmin, Yuhui Chen (150020), de Vivo, I., Hannu Martikainen (150049), Schwartz, S.M., Chanock, S.J. (Stephen), Chen, YH, Alexander Teumer, Kiel DP, Vasan, R.S. (Ramachandran Srini), Morin Papunen L, Karlsson, M. (Magnus), Jorma Viikari (49741), Chunyan He, Bandinelli Stefania, Wood AR, Raffel, Leslie, Mirel, D, Vasan RS, Chen, Y., Wellons M, Östen Ljunggren, Spector, T.D., Bhasin Shalender, Iva Miljkovic (150145), Wallaschofski H, Jong, F.A. (Floris) de, Steve Franks (150205), Reiner Alex P., Reincke M, Perry, John RB, Cox, David G, Laure Morin Papunen (150157), Prescott, J, Stolk, L, Markus, MRP, Jansson, John-Olov, Lohman, Kurt K., Bandinelli S, Koster, Annemarie; id_orcid, Lagou, V. (Vasiliki), Petersen, Ann-Kristin, Zhuang Wei Vivian, Schouw, Y.T. (Yvonne) van der, He, C., Soranzo N, Susan E Hankinson, Kathryn L Lunetta, de Jong, FH, He Chunyan, Dhananjay Vaidya (149887), Biffar, Reiner, Terho Lehtimäki, Lisette Stolk, Cox, D.G., Uitterlinden AG, Marc J. Gunter (148230), Zhuang WV, Liu, YM, Reiner, AP, Rivadeneira Ramirez, F. (Fernando), Chen Yuhui, Lorentzon, M, Harris, Tamara B, Murray Anna, Magnus Karlsson (150089), Kähönen M, Stolk, Lisette, Kettunen, Johannes, Nelson, S, Wichmann, H.-E., Reincke, M, Zhai, G., Morin Papunen, L, Kiel, D.P. (Douglas), Illig Thomas, Robin Haring, Bidlingmaier, M, Hartikainen Anna-Liisa, Myriam Fornage (45591), Liu Simin, Lehtimäki, T., Melissa Garcia (113622), Nelson, S. (Sarah), Thomas Illig (44906), John-Olov Jansson (150063), Karlsson, Magnus, Wallaschofski, H, Murray, Anna, Liu, S, Raffel, L., Wallaschofski, H., Stöckl D, Vasiliki Lagou (149920), Perry, John R. B., Zhai, GJ, Lunetta, Kathryn L., Vandenput Liesbeth, Zhai Guangju, Uitterlinden, AG, Wood, Andrew R., Illig, T. (Thomas), Haring, R., David Siscovick (103766), Gunter, M.J. (Marc J.), Tamara B Harris, Koster A, Bandinelli, S., Chen, B.H. (Brian), Rivadeneira F, Liu, Yong Mei, Karlsson, Magnus,, Hankinson, Susan, Hankinson, Susan E, Liu, J, Chanock, Stephen J, Hartikainen, Anna-Liisa, Harris, Tamara, Andrew R. Wood (149984), Wichmann, H-Erich, Ruokonen A, Lagou, Vasiliki, Chunyan He (149909), Ohlsson Claes, Ouyang, P., Brian Chen (149932), Keildson Sarah, Keildson, S. (Sarah), Prescott Jennifer, Homuth, G, Petersen, A.K., Vandenput, Liesbeth, Petersen AK, Cummings, Steven R, Gunter MJ, Jarvelin, M.R., Ferrucci, L. (Luigi), Lunetta Kathryn L., Martikainen, H., Mirel D, Frank H. de Jong (150208), Eriksson, J, N. Charlotte Onland-Moret (113650), van Gils Carla H., Simin Liu, Wood, AR, Garcia M, Gunter, M.J., Annemarie Koster, Garcia, M. (Melissa), Kettunen, J. (Johannes), Reincke Martin, Eriksson J, Vaidya, D. (Dhananjay), Liu J, Koster, Annemarie, Stöckl, D. (Doris), Kiel, Douglas P., Siscovick, David, Yong Mei Liu (149948), Liu S, Soranzo, N. (Nicole), Sarah Nelson (47538), van Gils, C.H., Miljkovic, Iva, Lagou, V., Vaidya, D, Stöckl, D, Immaculata De Vivo (150192), Markus, M.R.P. (Marcello R. P.), Bandinelli, Stefania, Prokopenko, Inga, Iva Miljkovic, Peeters Petra H. M., Morin Papunen, L. (Laure), Franks S, Frayling Timothy M., Petra H M Peeters, Hunter, David J, Miljkovic, I. (Iva), Chen Brian, Raffel, L.J. (Leslie), John R B Perry, Liesbeth Vandenput (149975), Henri Wallaschofski (112750), Martin Reincke (150169), Frayling TM, Liu Yong Mei, Inga Prokopenko (43252), Lohman, K, Ferrucci, L, Markus, Marcello R P, Prescott, C.A.J., Maggio, Marcello, Olli Raitakari (144269), Uitterlinden, A.G. (André), Wellons, M., Vivo, I. (Immaculata) de, Lund University., Alex P. Reiner (113675), Luigi Ferrucci, Douglas P Kiel, de Jong, Frank H, Yvonne T van der Schouw, Coviello, AD, Kähönen, Mika, Ann-Kristin Petersen (149959), Mika Kähönen, Homuth, G., De Vivo, I, H-Erich Wichmann, Onland-Moret, Charlotte N, Cox, D.G. (David), Wellons, Melissa, Hankinson, S.E., Raitakari, O, Ljunggren, Östen,, Vasiliki Lagou, Anna Murray (150202), Teumer, A., Joel Eriksson, Haring Robin, Terho Lehtimäki (49739), Ouyang Pamela, Frayling, TM, Gunter, Marc J., Reiner, Alex P., Teumer, A, Susan E. Hankinson (89927), van Gils, CH, McCarthy, M.I., Peeters PH, Joanne M Murabito, Koster, A., Cummings, S, Dan Mellström (150140), Stöckl Doris, Martikainen H, Homuth, Georg, Harris, TB, van Gils, Carla H, Martikainen, H. (Hannu), Lunetta, K.L. (Kathryn), Prokopenko Inga, Chanock, SJ, Bidlingmaier, M. (Martin), Melissa Wellons (149876), van Gils, Carla H., Wichmann H.-Erich, Claes Ohlsson, Vandenput, L, Petersen, AK, André G. Uitterlinden (2213413), Laure Morin Papunen, Hofman, Albert, Jansson, John-Olov,, Teumer Alexander, Mark I McCarthy, Chen, Y, Markus Marcello R. P., Vandenput, L. (Liesbeth), Mellström, D., Jong, Frank, Sarah Nelson, Chen, B, Georg Brabant (150011), Lyytikäinen, L.-P. (Leo-Pekka), David G. Cox (89928), Vasan, R.S., Wood Andrew R., Lehtimäki, T. (Terho), Zhai G, Karasik, D, Lyytikainen, Leo-Pekka, Kettunen, J, Peeters, PHM, Stefania Bandinelli, Spector, TD, Miljkovic Iva, Lorentzon Mattias, Wallaschofski Henri, Nelson Sarah, Mattias Lorentzon (121092), Johnson, Andrew D, Gunter, MJ, Lorentzon, M., Bidlingmaier, Martin, Wichmann, H. -Erich, Brabant, G. (Georg), Siscovick, D.S. (David), Kettunen Johannes, Peeters, P.H.M., Lunetta KL, Ferrucci, L., Hartikainen, A.L., Massimo Mangino (87550), Peter Kraft, Maggio, M, Wichmann, H.E. (Erich), Liu, J., Tworoger, S. (Shelley), Stolk L, Lehtimaki, Terho, van Gils CH, Anneli Pouta (116626), van der Schouw, Yvonne T, Lehtimäki, T, De Vivo Immaculata, Lorentzon M, Hunter, David, Ljunggren Ö, Hankinson, Susan E., Eriksson, Joel,, Reincke, Martin, Martikainen, Hannu, Hofman, Bert, Hartikainen AL, Prokopenko, I. (Inga), Tworoger, S, Kraft, P., Cummings, S., Liu, Y. (YongMei), Mellström Dan, Ferrucci, Luigi, Soranzo, N, Schwartz Stephen M., Siscovick, D, Jennifer Prescott, Markus, M.R., Spector, Tim D., Coviello, Andrea D, Simin Liu (11987), Zhai, G, Stephen J Chanock, Wood, A.R. (Andrew), Jorma Viikari, Haring, R, Mika Kähönen (131499), Ohlsson, C., Chen, B., Mark I. McCarthy (145748), Gunter, Marc J, Onland-Moret, N.C., Wichmann, H.-Erich, Melissa Wellons, Uitterlinden, André, Pouta, Anneli, Kraft, P, Immaculata De Vivo, Lorentzon, Mattias, Pouta A, Nelson, Sarah, Hankinson, S.E. (Susan), Miljkovic, I., Vaidya D, Tworoger, S., Hunter, D. (David), Lyytikäinen, LP, Rivadeneira, Fernando, Steven Cummings (150028), Bidlingmaier Martin, de Jong Frank H., Chanock SJ, Jarvelin, M-R, Kathryn Rexrode (150173), Harris, T.B., Lagou V, David G Cox, Mangino, Massimo, Olli Raitakari, Ohlsson, Claes,, Liu, Y.M., Coviello, Andrea D., Lunetta, K.L., Karlsson, M, Viikari, J., Mangino M, Zhai, Guangju, Jansson, J-O, Vasan Ramachandran S., Kiel, DP, Johnson, AD, Liu, SM (Simin), Alex P Reiner, Siscovick, D., Petersen, A.-K., Petra H. M. Peeters (115139), McCarthy, Mark I., Massimo Mangino, Harris, Tamara B., Hunter, David J., Peter Kraft (15118), McCarthy MI, de Jong, Frank H., Onland-Moret, N Charlotte, Steve Franks, Cox DG, Lohman, K. (Kurt), Bindlingmaier, Martin, Pamela Ouyang (150198), Uitterlinden, André; id_orcid, Rexrode Kathryn, Timothy M. Frayling (145700), Rivadeneira, F., Chanock Stephen J., Reiner Biffar (135695), Garcia, Melissa, Viikari, J, Reiner, A.P. (Alex), Liu, S., Markus MR, Jansson, J.O., Ljunggren, O., Prokopenko, I., Magnus Karlsson, Andrew R Wood, Kraft, P. (Peter), Bhasin, Shalender, de Jong, F.H., Coviello, A.D. (Andrea), Karlsson M, Fornage, M. (Myriam), Perry John R. B., Vaidya, D., Joel Eriksson (149940), Harris Tamara B., Brabant, Georg, André G Uitterlinden, Hankinson, SE, Maggio, M. (Marcello), Shelley Tworoger, Reincke, M. (Martin), Zhuang, W.V., Nicole Soranzo, Joanne M. Murabito (150212), Annemarie Koster (66337), Mangino, M. (Massimo), Nelson, S., Spector, Tim D, Uitterlinden, A.G., Karasik, David, Teumer A, John R. B. Perry (150215), Eriksson Joel, Wichmann, Heinz-Erich, Biffar, R. (Reiner), Robin Haring (149871), Franks Steve, Ohlsson C, Anna Murray, Ouyang P, Peeters, PH, Keildson S, Hartikainen, A-L, Ferrucci L, Spector TD, Koster, A. (Annemarie), Lagou Vasiliki, Raffel Leslie, Lagou, V, Georg Homuth, Shalender Bhasin, Haring R, de Jong FH, Raitakari, O. (Olli), Marcello Maggio (150126), Hofman, A, Kraft P, Perry, John R B, Frayling, T.M., Albert Hofman (107303), Garcia, M, Onland-Moret N. Charlotte, Andrea D Coviello, Bidlingmaier M, Andrew D Johnson, Ouyang, P. (Pamela), Morin Papunen, L., Raffel L, Bhasin, S. (Shalender), Eriksson, J. (Joel), Mellström, D. (Dan), Murabito, Joanne M, Lohman, K., Marjo-Riitta Järvelin, Anna-Liisa Hartikainen (110272), Marjo-Riitta Järvelin (2141947), Ohlsson, Claes, Kettunen, J., Morin Papunen Laure, Papunen, LM, Jansson John-Olov, Johnson Andrew D., Maggio Marcello, Fernando Rivadeneira (61551), Sarah Keildson (149896), Karasik David +864 morecore +1 more sourceEcological Adaptation Mechanisms Underlying Successful Plant Reproduction
Advanced Science, EarlyView.During floral induction, various environmental and endogenous signals converge to regulate the florigen protein, which is transported from leaves to the SAM to initiate flowering. Within the SAM, a complex network of receptor kinases and small peptides orchestrates floral development with high spatiotemporal precision.Hang Zhao, Shenghui Huo, Yue Xing, Shuxin Zhang, Guilin Li, Yihui Liu, Chongyang Jin, Fuguang Li, Xiaoyang Ge +8 morewiley +1 more sourceT Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun +7 morewiley +1 more source
