Results 111 to 120 of about 1,680,257 (302)

Sex hormones differently regulate lipid metabolism genes in primary human hepatocytes

BMC Endocrine Disorders
Background Prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) is higher in men than in women. Hormonal and genetic causes may account for the sex differences in MASLD.
Lena Seidemann, Clara Paula Lippold, Carolin Marie Rohm, Julian Connor Eckel, Gerda Schicht, Madlen Matz-Soja, Thomas Berg, Daniel Seehofer, Georg Damm   +8 more
doaj   +1 more source

Sex hormones and cancer.

, 1992
There are few instances in which a clear effect of hormones on cancer risk is known and in which the effects of those hormones on the cells concerned are also known. The best examples are the relationships between sex hormones and cancer in women.
Key, TJ, Key, Timothy, Beral, Valerie, Beral, V   +3 more
core  

Sex Steroid Hormones

Sex steroid hormones play a crucial role in reproductive physiology, influencing various aspects of sexual development, reproductive function and overall health.

core   +1 more source

CYP3A variation, premenopausal estrone levels, and breast cancer risk.

, 2012
BACKGROUND: Epidemiological studies have provided strong evidence for a role of endogenous sex steroids in the etiology of breast cancer. Our aim was to identify common variants in genes involved in sex steroid synthesis or metabolism that are associated
Gibson, Lorna J, Jones, M, Tomlinson, IP, Ross, G, Folkerd, Elizabeth, Hillier, Stephen G, Schoemaker, M, Sawyer, Elinor, Folkerd, E, Kerin, M, Ross, Gillian, Peto, Julian, Swerdlow, A, Johnson, Nichola, Tomlinson, Ian P., Coupland, Ben, Fletcher, Olivia, Haynes, Ben, Kerin, Michael J, Williamson, Jill, Schoemaker, Minouk, Coupland, B, Simpson, Gemma, Palles, Claire, Ashworth, A, Dowsett, M, Houlston, RS, Johnson, N, Swerdlow, Anthony, Jones, Michael, Chilcott-Burns, S, Dos-Santos-Silva, Isabel, Williamson, J, Broderick, P, Zvelebil, M, Dowsett, Mitch, Walker, Kate, Fletcher, O, Houlston, Richard S, Dos Santos Silva, I, Kerin, Michael, Tomczyk, K, Walker, K, Palles, C, Zvelebil, Marketa, Gibson, Lorna J., Ashworth, Alan, Tomlinson, Ian P, Tomczyk, Katarzyna, Simpson, G, Orr, Nick; id_orcid, Orr, Nick, Orr, N, Swerdlow, Anthony J, Houlston, Richard S., Peto, J, Dos Santos Silva, Isabel, Hillier, Stephen G., Haynes, B, Hillier, SG, Sawyer, E, Broderick, Peter, Chilcott-Burns, Sarah, Gibson, LJ, Walker-Springett, Kate   +64 more
core   +1 more source

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

Advanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu, Ajun Geng, Ziyuan Li, Fanghao Guo, Jingqiang Wang, Xinyi Chen, Meiling Zhang, Yi Arial Zeng, Wen Li   +8 more
wiley   +1 more source

Endogenous sex hormones and prostate cancer: A collaborative analysis of 18 prospective studies

, 2008
Background: Sex hormones in serum have been hypothesized to influence the risk of prostate cancer. We performed a collaborative analysis of the existing worldwide epidemiologic data to examine these associations in a uniform manner and to provide more ...
Roddam, AW, Key, TJ, Holly, Jeffrey M P, Donovan, Jenny L, Allen, NE, Appleby, P, Endogenous Hormones & Prostate Cancer Collaborative, Group   +6 more
core   +1 more source

Integrating Genetics With Epidemiological Measurements Identifies Burden QTLs of Inflammatory Bowel Disease across 20 Countries

Advanced Science, EarlyView.
The burden quantitative trait locus (bQTL) analysis integrates epidemiological data from GBD study with genotype of 2 621 978 SNPs from 2414 individuals in 1000 Genomes Project across 20 countries. rs7633471 shows the strongest effect that each increase in centi‐allele frequency of the allele C associated with 10.00 decrease of age‐standardized ...
Chen Sun, Siyu Wei, Junxian Tao, Haiyan Chen, Chi Yan, Jiacheng Wang, Jing Xu, Lian Duan, Yuanbo Zhan, Yuping Zou, Ruilin Li, Linna Yuan, Wei She, Songlin Lu, Ning Wang, Qinduo Ren, Yan Guo, Yuan Xu, Chang Wang, Hongsheng Tian, Chen Zhang, Yu Dong, Guoping Tang, Zhenwei Shang, Yongshuai Jiang, Wenhua Lv, Mingming Zhang, Hongchao Lyu   +27 more
wiley   +1 more source

Causal relationship between inflammatory bowel disease and sex: a Mendelian randomization study

Frontiers in Endocrinology
ObjectiveThe aim of this study was to investigate the bidirectional causal relationship between sex hormones and IBD through a two-sample bidirectional Mendelian randomization (MR) study.MethodsBased on Genome-Wide Association Study (GWAS) pooled data on
Kaiwen Wang, Yu Lou, Shunjie Tian, Zhihui Tao, Zhihui Tao   +4 more
doaj   +1 more source

TRAIP Mediates Alcohol‐Induced Liver Injury through Regulating β‐catenin Ubiquitin Degradation via Direct Interaction

Advanced Science, EarlyView.
This study reveals that NF‐κB1‐driven TRAIP upregulation in ALD correlates with disease severity. Mechanistically, TRAIP directly binds β‐catenin via its CC domain and promotes its K48‐linked ubiquitination and degradation, which is independent of the GSK3β/β‐TrCP pathway.
Zhan Wu, Mingjiang Liu, Lijuan Liao, Zhaohong Mo, Wenli Xu, Linfeng Mao, Yubing Chen, Qiuli Xie, Ming Yao, Shilian Chen, Stephen Tomlinson, Sebastian Mueller, Songqing He, Guandou Yuan   +13 more
wiley   +1 more source

Underground Signals: The Ecological Power of Root Volatiles

Advanced Science, EarlyView.
Root volatiles mediate rhizosphere chemical communication, shaping interactions among plants, microbes, herbivores, and natural enemies. Their production, transport, and perception underpin ecological adaptation, multitrophic interactions, and plant resilience, offering opportunities for sustainable crop protection, resilient agroecosystems, and ...
Xueyao Cao, Nanli Song, François Verheggen, Meritxell Pérez‐Hedo, Andrea Clavijo McCormick, Antonino Cusumano, Arthur de Fouchier, Bing Wang, Chen‐Zhu Wang, Emmanuelle Jacquin‐Joly, Gary W. Felton, Geoff M. Gurr, Hao Guo, Jiancai Li, Jin Zhang, Li Chen, Manqun Wang, Michele Ricupero, Peng Han, Peng He, Qi Yan, Qingbo Tang, Qingsong Liu, Shiheng An, Xiangbo Kong, Xiaoling Sun, Xueming Ren, Yuanyuan Song, Yang Liu, Yanhui Guo, Yunhe Li, Xiao Sun   +31 more
wiley   +1 more source