Results 131 to 140 of about 199,488 (284)

Integrin β3 Orchestrates Hepatic Steatosis via a Novel CD36‐Dependent Lipid Uptake Complex

Advanced Science, EarlyView.
In MASH, ITGB3 recruits LYN and drives its ubiquitin‐proteasomal degradation via phosphorylation. This relieves DHHC5 inhibition, enabling ITGB3/DHHC5/CD36 complex assembly to enhance CD36 palmitoylation and fatty acid uptake, thereby exacerbating disease. Targeting ITGB3 blocks this pathogenic axis and ameliorates MASH.
Ying Zhang, Lei Dai, Zhongquan Cui, Ye Zhou, Wenyuan Dong, Hongcheng Jiang, Mengwen Wang, Xiaodan Zhong, Wei Dong, Zhang Yue, Thati Madhusudhan, Hongjie Wang, Xiong Zhong Ruan, Hesong Zeng   +13 more
wiley   +1 more source

Longitudinal changes in sex hormones in a population of older community dwelling men. [PDF]

J Clin Endocrinol Metab
Hills ST, Mansfield TA, Bhasin S, Orwoll ES.   +3 more
europepmc   +1 more source

Plasma Sex Steroid Hormone and Vitellogenin Profiles during Ovarian Development of the Wild Marbled Sole (Limanda yokohamae) [PDF]

, 2006
Dae Jung Kim, Cheul‐Min An, Kwang-Sik Min   +2 more
openalex   +1 more source

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

Advanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen   +2 more
wiley   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Sex differences in associations between white matter microstructure and gonadal hormones in children and adolescents with prenatal alcohol exposure

, 2017
Kristina A. Uban, Megan M. Herting, Jeffrey R. Wozniak, Elizabeth R. Sowell   +3 more
openalex   +2 more sources

Exploring the Vasculitis‐Tumors Link: Epidemiological Patterns, Mechanistic Insights, and Clinical Implications

Advanced Science, EarlyView.
This review outlines association between vasculitis and malignancies and provides practical value for clinicians in distinguishing primary vasculitis from malignancy‐associated forms and optimizing patient surveillance, improving recognition of tumor‐associated vasculitis to reduce the risk of misdiagnosis, supporting more accurate clinical decision ...
Xiaofei Shi, Zhijiao Li, Xin Ma, Bei Zhang, Xinfeng Wu, Hua Fan, Rongzeng Liu, Hongwei Jiang, Cong‐Qiu Chu   +8 more
wiley   +1 more source

Sex, hormones, and lung health. [PDF]

Physiol Rev
Silveyra P, Babayev M, Ekpruke CD.
europepmc   +1 more source

Effect of metformin and P. dioscoridis on sex hormonal profile and brain dopamine level in letrozole-induced PCOS.

Rasha Atta (21608582), Sahar Galal Gouda (21608585), Marwa Hussein Mohamed (21608588), Sherif M. Afifi (11958218), Mahmoud I. Nassar (11156602), Mohamed A. Farag (116453), Abdelsamed I. Elshamy (8321535), Mohamed A. Zayed (8026154), Thamer Alqurashi (21608591), Shimaa Mohammad Yousof (21608594)   +9 more
openalex   +1 more source

Joint relative risks for estrogen receptor-positive breast cancer from a clinical model, polygenic risk score, and sex hormones

, 2017
Yiwey Shieh, Donglei Hu, Lin Ma, Scott Huntsman, Charlotte C. Gard, Jessica W. T. Leung, Jeffrey A. Tice, Elad Ziv, Karla Kerlikowske, Steven R. Cummings   +9 more
openalex   +2 more sources