Results 151 to 160 of about 409,329 (299)

Fosl2 Regulates FSH‐Dependent Follicle Maturation Through Feedback Amplification of FSH/FSHR Signaling

open access: yesAdvanced Science, EarlyView.
This study identifies a FOSL2‐driven positive feedback loop that amplifies FSH/FSHR signaling. During FSH‐dependent follicle maturation, FSH induces Fosl2 expression via the cAMP‐PKA‐CREB cascade. FOSL2 in turn binds the promoters of Fshr and estrogen‐biosynthesis genes to enhance their transcription, thereby increasing Fshr mRNA level and amplifying ...
Hongru Shi   +13 more
wiley   +1 more source

Paternal Caffeine Exposure Programs Offspring Stress Vulnerability via Sperm Dlk1‐Dio3 Imprinting‐Directed Remodeling of a Novel Neural Circuit

open access: yesAdvanced Science, EarlyView.
The study elucidates that paternal preconception stress can drive offspring hyperresponsivity of the stress system via hypomethylation of a specific DNA region in sperm. This key link is confirmed in a cohort of prospective fathers: the epigenetic alteration is associated with elevated stress hormone levels.
Mengxi Lu   +10 more
wiley   +1 more source

Reduced CB1 Cannabinoid Receptor Expression in Alzheimer's Disease and Transgenic Mouse Models

open access: yesAGING MEDICINE, EarlyView.
CB1 receptor (CB1R) expression was significantly reduced in the hippocampus, medial frontal gyrus, and superior temporal gyrus of Alzheimer's patients. CB1R levels negatively correlated with amyloid‐β and tau pathology. In addition, CB1R expression was also reduced in the cortex of 5xFAD mice and in the hippocampus of Tg4‐42 mice.
Nike von Borcke   +4 more
wiley   +1 more source

Neuroglial Function and Hormonal Modulation in Neurodegenerative Diseases: The Influence of Sex Hormones. [PDF]

open access: yesCell Mol Neurobiol
Alhajeri MM   +10 more
europepmc   +1 more source

Gender Disparities in the Prevalence, Trends, and Determinants of Later‐Life Urinary Incontinence: A Disproportionate Burden on Women

open access: yesAGING MEDICINE, EarlyView.
This study shows that UI prevalence rose steadily in both the USA and UK during the 2010s, driven by aging, comorbidities, and educational changes, with women accounting for 65% of the projected increase in UI cases by 2030. These findings underscore the need for gender‐responsive UI prevention and care strategies, including targeted interventions for ...
Xiyin Chen   +5 more
wiley   +1 more source

Ocular tissue responses to sex hormones

open access: yesIndian Journal of Endocrinology and Metabolism, 2012
Sukhwinder Kaur Bajwa   +2 more
doaj   +1 more source

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