Results 111 to 120 of about 19,190 (266)

SRSF2 Is Essential For Hematopoiesis and Its Mutations Dysregulate Alternative RNA Splicing In MDS [PDF]

open access: yes, 2013
Myelodysplastic syndromes (MDS) are a group of neoplasms that are ineffective in generating multiple lineages of myeloid cells and have various risks to progress to acute myeloid leukemia.
Chen, Liang   +10 more
core  

Age and Sex Effects on Blood Retrotransposable Element Expression Levels: Findings From the Population‐Based Rhineland Study

open access: yesAging Cell, EarlyView.
Retrotransposable element (RTE) expression increases with chronological and biological age and is negatively associated with heterochromatin regulators. Moreover, RTE expression shows sex‐specific differences, with higher levels in men and enrichment for immune‐related pathways.
Valentina Talevi   +6 more
wiley   +1 more source

Predicting survival in patients with myelodysplastic/myeloproliferative neoplasms with SF3B1 mutation and thrombocytosis

open access: yesLeukemia
We investigated data from 180 consecutive patients with myelodysplastic/myeloproliferative neoplasms with SF3B1 mutation and thrombocytosis (MDS/MPN-SF3B1-T) who were diagnosed according to the 2022 World Health Organization (WHO) classification of ...
Fuhui Li   +15 more
semanticscholar   +1 more source

SF3B1 mutated MDS: Blast count, genetic co-abnormalities and their impact on classification and prognosis

open access: yesLeukemia, 2022
Recently, MDS with mutated SF3B1 and blast count 5% was not. In conclusion, SF3B1mut MDS has a favorable prognosis independent of blast count if karyotype and RUNX1 mutations are considered.
S. Huber   +7 more
semanticscholar   +1 more source

Analysis of SF3B1 mutations in monoclonal B‐cell lymphocytosis [PDF]

open access: yesHematological Oncology, 2012
[No abstract available]
Mariangela Greco   +11 more
openaire   +5 more sources

Genocopy of EVI1‐AML with paraneoplastic diabetes insipidus: PRDM16 overexpression by t(1;2)(p36;p21) and enhancer hijacking

open access: yesBritish Journal of Haematology, EarlyView.
Summary Diabetes insipidus (DI) in patients with acute myeloid leukaemia (AML) and chromosome 3q alterations (EVI1/PRDM3/MECOM overexpression) constitutes a poorly understood paraneoplasia. A 44‐year‐old patient presented with clinical and morphological features of this syndrome but, surprisingly, disclosed the rare translocation t(1;2)(p36;p21), with ...
Julian List   +9 more
wiley   +1 more source

SF3B1 homeostasis is critical for survival and therapeutic response in T cell leukemia

open access: yesScience Advances, 2022
The production of noncanonical mRNA transcripts is associated with cell transformation. Driven by our previous findings on the sensitivity of T cell acute lymphoblastic leukemia (T-ALL) cells to SF3B1 inhibitors, we identified that SF3B1 inhibition ...
Cuijuan Han   +23 more
semanticscholar   +1 more source

SF3B1 facilitates HIF1-signaling and promotes malignancy in pancreatic cancer

open access: yesCell Reports, 2022
ISSN:2211 ...
Simmler, Patrik   +24 more
openaire   +4 more sources

The SF3B1 inhibitor spliceostatin A (SSA) elicits apoptosis in chronic lymphocytic leukemia cells through downregulation of Mcl-1

open access: yes, 2015
The pro-survival Bcl-2 family member Mcl-1 is expressed in chronic lymphocytic leukemia (CLL), with high expression correlated with progressive disease.
Blakemore, S.J.   +14 more
core   +1 more source

Clinical management of CMML—State of the art

open access: yesBritish Journal of Haematology, EarlyView.
Patients with chronic myelomonocytic leukaemia (CMML) typically present with clinical feature including splenomegaly, constitutional symptoms and autoimmune phenomena, as well as with pathological blood counts and biological features in the marrow. These characteristics may influence the assignment to prognostic categories such as the CPSSmol and also ...
K. Nachtkamp   +3 more
wiley   +1 more source

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