Results 111 to 120 of about 21,005 (271)

Significance of Myelodysplasia‐Related Mutations and the Genetic Landscape of Acute Leukemias of Ambiguous Lineage

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT The recent fifth edition WHO classification and ICC classification systems have moved further toward genetically defined classifications of acute leukemias. Both now recognize myelodysplasia‐related (MR) mutations as defining of MDS‐related AML (AML‐MR).
Timothy J. Kirtek, Olga K. Weinberg
wiley   +1 more source

Targeted therapy and outcome in chronic lymphocytic leukemia [PDF]

, 2014
Despite major advances, chronic lymphocytic leukemia (CLL) is still considered incurable. Fludarabine refractory patients and those with TP53disruptions have a particularly poor prognosis.
Eketorp Sylvan, Sandra
core   +1 more source

Cancer-associated SF3B1-K700E mutation controls immune responses by regulating Treg function via aberrant Anapc13 splicing

Science Advances
Recurrent somatic mutations in spliceosome factor 3b subunit 1 (SF3B1) are identified in hematopoietic malignancies, with SF3B1-K700E being the most common one. Here, we show that regulatory T cell (Treg)–specific expression of SF3B1-K700E (Sf3b1K700Efl/+
Yun Shi, Wencan Zhang, Qiong Jia, Xiancai Zhong, Prajish Iyer, Hongmin Wu, Yate-Ching Yuan, Yuqi Zhao, Lianjun Zhang, Lili Wang, Zhenyu Jia, Ya-Huei Kuo, Zuoming Sun   +12 more
semanticscholar   +1 more source

SF3B1 and BAP1 mutations in blue nevus-like melanoma [PDF]

Modern Pathology, 2017
Blue nevi are melanocytic tumors originating in the cutaneous dermis. Malignant tumors may arise in association with or resembling blue nevi, so called 'blue nevus-like melanoma', which can metastasize and result in patient death. Identifying which tumors will behave in a clinically aggressive manner can be challenging.
Griewank, Klaus, Müller, Hansgeorg, Jackett, Louise A., Emberger, Michael, Möller, Inga, van de Nes, Johannes, Zimmer, Lisa, Livingstone, Elisabeth, Wiesner, Thomas, Scholz, Simone L., Cosgarea, Ioana, Sucker, Antje, Schimming, Tobias, Hillen, Uwe, Schilling, Bastian, Paschen, Annette, Reis, Henning, Mentzel, Thomas, Kutzner, Heinz, Rütten, Arno, Murali, Rajmohan, Scolyer, Richard A., Schadendorf, Dirk   +22 more
openaire   +2 more sources

Common Hematologic Emergencies—Acute Promyelocytic Leukemia and Microangiopathic Hemolytic Anemias—A Pivotal Role of Clinical Laboratory

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Hematologic emergencies are urgent health conditions which result in significant mortality and morbidity unless timely therapeutic measures are taken. Therapeutic success depends on their timely and accurate recognition by hematology laboratory services.
Ganna Shestakova, Nicolas Ulrich Edgar, Anton V. Rets   +2 more
wiley   +1 more source

Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer. [PDF]

, 2018
Functional redundancy shared by paralog genes may afford protection against genetic perturbations, but it can also result in genetic vulnerabilities due to mutual interdependency1-5.
Berger, Ashton C, Bhatia, Sangeeta N, Buss, Colin G, Carr, Steven A, Cherniack, Andrew D, Choi, Peter S, Hahn, William C, Krill-Burger, John M, Lage, Kasper, Malolepsza, Edyta, Meyerson, Matthew, Nogueira, Marina F, Pedamallu, Chandra Sekhar, Schenone, Monica, Shih, Juliann, Strathdee, Craig A, Tamayo, Pablo, Tanenbaum, Benjamin, Taylor, Alison M, Tsherniak, Aviad, Vazquez, Francisca, Viswanathan, Srinivas R, Wawer, Mathias J   +22 more
core   +1 more source

Allele Loss and Reduced Expression of CYCLOPS Genes is a Characteristic Feature of Chromophobe Renal Cell Carcinoma

Translational Oncology, 2019
Copy-number alterations Yielding Cancer Liabilities Owing to Partial losS (CYCLOPS) genes have been recently identified as the most enriched class of copy-number associated gene dependencies in human cancer.
Riuko Ohashi, Peter Schraml, Aashil Batavia, Silvia Angori, Patrik Simmler, Niels Rupp, Yoichi Ajioka, Esther Oliva, Holger Moch   +8 more
doaj   +1 more source

MicroRNA biogenesis is broadly disrupted by inhibition of the splicing factor SF3B1

Nucleic Acids Research
In animals, microRNA (miRNA) biogenesis begins with cotranscriptional cleavage of the primary (pri-)miRNA by the Microprocessor complex. Cotranscriptional splicing has been shown to influence Microprocessor cleavage when miRNAs are hosted in introns of ...
Angela Downie Ruiz Velasco, Aimee Parsons, Matthew C Heatley, Athena R G Martin, Alfredo D. Smart, Niraj Shah, C. Jopling   +6 more
semanticscholar   +1 more source

Advancements in genetic analysis: Insights from a case study and review of next‐generation sequencing techniques for veterinary oncology applications

Veterinary Clinical Pathology, EarlyView.
Abstract Acute myeloid leukemia (AML) poses significant challenges in veterinary medicine, with limited treatment options and poor survival rates. While substantial progress has been made in characterizing human AML, translating these advancements to veterinary practice has been hindered by limited molecular understanding and diagnostic tools. The case
R. Adam Harris, Jillian Nolan, Dylan Ammons, Samantha Beeson, Douglas Thamm, Anne Avery   +5 more
wiley   +1 more source

Comparing Nonparametric Bayesian Tree Priors for Clonal Reconstruction of Tumors

, 2014
Statistical machine learning methods, especially nonparametric Bayesian methods, have become increasingly popular to infer clonal population structure of tumors.
Deshwar, Amit G., Morris, Quaid, Vembu, Shankar   +2 more
core   +1 more source