Results 131 to 140 of about 19,190 (266)
Clonal Hematopoiesis and Solid Cancers
Cancer Science, EarlyView.This review explores the relationship between clonal hematopoiesis and solid cancers. Clonal hematopoiesis mutations influence the tumor microenvironment by altering immune regulation, inflammation, and angiogenesis. Understanding these mutations has important clinical implications, including their role in prognosis, treatment response, and potential ...
Yen T. M. Nguyen +3 more
wiley +1 more source
Blood Advances, 2019 : The spliceosomal component Splicing Factor 3B, subunit 1 (SF3B1) is one of the most prevalently mutated factors in the bone marrow failure disorder myelodysplastic syndrome.
Adriana De La Garza +5 more
doaj
SF3B1: hotspot mutazionale nei prolattinomi [PDF]
L'Endocrinologo, 2021 G. Mantovani, F. Mangili
openaire +2 more sources
Journal of Experimental & Clinical Cancer Research, 2021 Background Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer, requiring novel treatments to target both cancer cells and cancer stem cells (CSCs).
Emilia Alors-Perez +25 more
doaj +1 more source
Clinical Images: Penetrating aortic ulceration as an initial presentation of Erdheim‐Chester disease
Arthritis &Rheumatology, EarlyView.
Jerome Razanamahery, Bernard Bonnotte
wiley +1 more source
International Journal of Laboratory Hematology, EarlyView.ABSTRACT The recent fifth edition WHO classification and ICC classification systems have moved further toward genetically defined classifications of acute leukemias. Both now recognize myelodysplasia‐related (MR) mutations as defining of MDS‐related AML (AML‐MR).
Timothy J. Kirtek, Olga K. Weinberg
wiley +1 more source
The Spliceosomal Component Sf3b1 Is Essential for Hematopoietic Differentiation
Blood, 2015 Abstract Myelodysplastic syndrome (MDS) is a disorder arising from hematopoietic stem and progenitor cell (HSPC) dysfunction resulting in ineffective hematopoiesis. A multitude of recurrent somatic mutations in spliceosomal components were recently identified in MDS that likely contribute to the pathogenesis of the disease.
Rosannah C. Cameron +5 more
openaire +2 more sources
PLoS ONE, 2020 Mutations in the splicing machinery have been implicated in a number of human diseases. Most notably, the U2 small nuclear ribonucleoprotein (snRNP) component SF3b1 has been found to be frequently mutated in blood cancers such as myelodysplastic ...
Harpreet Kaur +4 more
doaj +1 more source
Targeting the spliceosome for cutaneous squamous cell carcinoma therapy:a role for c-MYC and wild-type p53 in determining the degree of tumour selectivity [PDF]
, 2018 This study was supported by DEBRA International and funded by DEBRA Austria (Saville-Proby 1). I.M.L and M.K.S were supported by an ERC Advanced Investigator Award (250170, Principal Investigator I.M.L.). C.M.P. and I.M.L.
Boag, Garry +6 more
core +2 more sources
International Journal of Laboratory Hematology, EarlyView.ABSTRACT Hematologic emergencies are urgent health conditions which result in significant mortality and morbidity unless timely therapeutic measures are taken. Therapeutic success depends on their timely and accurate recognition by hematology laboratory services.
Ganna Shestakova +2 more
wiley +1 more source