Results 161 to 170 of about 19,190 (266)

Cancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usage

Nature Communications, 2016
Mutations in the splicing factor SF3B1 are found in uveal melanoma. Here, Alsafadi et al. use RNA-sequencing data from these cancers and experimental models, and show that mutant SF3B1 promotes alternative branchpoints in a specific gene subset and that ...
Samar Alsafadi, Alexandre Houy, Aude Battistella, Tatiana Popova, Michel Wassef, Emilie Henry, Franck Tirode, Angelos Constantinou, Sophie Piperno-Neumann, Sergio Roman-Roman, Martin Dutertre, Marc-Henri Stern   +11 more
doaj   +1 more source

Clinical significance of SF3B1 mutations in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms [PDF]

, 2011
Luca Malcovati, Elli Papaemmanuil, David Bowen, Jacqueline Boultwood, Matteo Giovanni Della Porta, Cristiana Pascutto, Erica Travaglino, Michael J. Groves, Anna L. Godfrey, Ilaria Ambaglio, Anna Gallì, Matteo C. Da Vià, Simona Conte, Sudhir Tauro, Norene Keenan, Ann Hyslop, Jonathan Hinton, Laura Mudie, James S. Wainscoat, P. Andrew Futreal, Michael R. Stratton, Peter J. Campbell, Eva Hellström‐Lindberg, Mario Cazzola   +23 more
openalex   +1 more source

The expression and signalling patterns of CD180 toll like receptor in Chronic Lymphocytic Leukaemia (CLL) [PDF]

, 2019
Chronic lymphocytic leukaemia (CLL) is characterised by a progressive accumulation of mature CD5+CD20+CD23+ lymphocytes. Despite the remarkable progress in our understanding of the immunobiology of CLL, the aetiology of the disease remains unknown.
Sayed, U., Sayed, U.
core  

Rewards of divergence in sequences, 3-D structures and dynamics of yeast and human spliceosome SF3b complexes

Current Research in Structural Biology, 2021
The evolution of homologous and functionally equivalent multiprotein assemblies is intriguing considering sequence divergence of constituent proteins.
Arangasamy Yazhini, Sankaran Sandhya, Narayanaswamy Srinivasan   +2 more
doaj  

Dysregulated GPCR Signaling and Therapeutic Options in Uveal Melanoma. [PDF]

, 2017
Uveal melanoma is the most common primary intraocular malignant tumor in adults and arises from the transformation of melanocytes in the uveal tract. Even after treatment of the primary tumor, up to 50% of patients succumb to metastatic disease.
Aplin, Andrew E., Benovic, Jeffrey L., Chua, Vivian, Lapadula, Dominic, Randolph, Clinita, Wedegaertner, Philip B.   +5 more
core   +1 more source

P1052: IMPACT OF SF3B1 MUTATION IN MYELOFIBROSIS

HemaSphere, 2022
J. Senapati, S. Verstovsek, L. Masarova, N. Pemmaraju, G. Montalban Bravo, S. Pierce, L. Zhou, G. Garcia-Manero, H. Kantarjian, P. Bose   +9 more
openaire   +2 more sources

Depletion of Sf3b1 impairs proliferative capacity of hematopoietic stem cells but is not sufficient to induce myelodysplasia [PDF]

, 2014
Changshan Wang, Goro Sashida, Atsunori Saraya, Reiko Ishiga, Shuhei Koide, Motohiko Oshima, Kyoichi Isono, Haruhiko Koseki, Atsushi Iwama   +8 more
openalex   +1 more source

Erythroid‐stimulating agents in VEXAS syndrome: A retrospective study from an Italian multicentre cohort

British Journal of Haematology, Volume 207, Issue 1, Page 273-277, July 2025.
E. Diral, C. Campochiaro, G. Furnari, F. Moretti, J. Ferrari, C. Elena, G. Battipaglia, S. Barbato, A. Vitale, M. Frigeni, F. Crisafulli, M. Frassi, C. Papayannidis, A. D. Romagnoli, C. Cattaneo, A. D'Ambrosio, E. Morsia, P. Musto, G. Rivoli, M. E. Dragani, C. Toffalori, G. M. Bergonzi, G. Scorpio, A. Tomelleri, M. T. Voso, C. Gurnari, L. Vago, L. Dagna, F. Ciceri   +28 more
wiley   +1 more source

Allele Loss and Reduced Expression of CYCLOPS Genes is a Characteristic Feature of Chromophobe Renal Cell Carcinoma

Translational Oncology, 2019
Copy-number alterations Yielding Cancer Liabilities Owing to Partial losS (CYCLOPS) genes have been recently identified as the most enriched class of copy-number associated gene dependencies in human cancer.
Riuko Ohashi, Peter Schraml, Aashil Batavia, Silvia Angori, Patrik Simmler, Niels Rupp, Yoichi Ajioka, Esther Oliva, Holger Moch   +8 more
doaj  

m6A-driven SF3B1 translation control steers splicing to direct genome integrity and leukemogenesis.

Molecules and Cells, 2023
M. Cieśla, P. Ngoc, Sowndarya Muthukumar, G. Todisco, M. Madej, H. Fritz, M. Dimitriou, Danny Incarnato, E. Hellström-Lindberg, C. Bellodi   +9 more
semanticscholar   +1 more source