Results 161 to 170 of about 21,005 (271)
Biologic and clinical significance of somatic mutations of SF3B1 in myeloid and lymphoid neoplasms [PDF]
, 2012 Mario Cazzola +2 more
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SF3B1: the lord of the rings in MDS [PDF]
Blood, 2020 Francesc Solé, Laura Palomo
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Molecular Therapy: Nucleic AcidsSplicing factor 3b subunit 1 (SF3B1) is the largest subunit and core component of the spliceosome. Inhibition of SF3B1 was associated with an increase in broad intron retention (IR) on most transcripts, suggesting that IR can be used as a marker of ...
Manoj Kumar Kashyap +19 more
doaj +1 more source
SF3B1 mutation predicts unfavorable treatment-free survival in Chinese chronic lymphocytic leukemia patients [PDF]
, 2019 Yi Miao +13 more
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SF3B1 thermostability as an assay for splicing inhibitor interactions
Journal of Biological ChemistryThe spliceosome protein, SF3B1 associates with U2 snRNP during early spliceosome assembly for pre-mRNA splicing. Frequent somatic mutations in SF3B1 observed in cancer necessitates characterization of its role in identifying the branchpoint adenosine of introns. Remarkably, SF3B1 is the target of three distinct natural product drugs, each identified by
Angela N. Amorello +5 more
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The splicing modulator sudemycin induces a specific antitumor response and cooperates with ibrutinib in chronic lymphocytic leukemia [PDF]
, 2015 Aymerich, Marta +12 more
core +1 more source
Transcriptomic Characterization of SF3B1 Mutation Reveals Its Pleiotropic Effects in Chronic Lymphocytic Leukemia [PDF]
, 2016 Lili Wang +34 more
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Supplementary Figure 1 from Engineering Oncogenic Hotspot Mutations on <i>SF3B1</i> via CRISPR-Directed PRECIS Mutagenesis [PDF]
Mike M. Fernandez +7 more
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