Results 11 to 20 of about 19,190 (266)

Mutant SF3B1 promotes malignancy in PDAC

eLife, 2023
The splicing factor SF3B1 is recurrently mutated in various tumors, including pancreatic ductal adenocarcinoma (PDAC). The impact of the hotspot mutation SF3B1K700E on the PDAC pathogenesis, however, remains elusive.
Patrik T. Simmler, Eleonora I Ioannidi, Tamara Mengis, K. Marquart, Simran Asawa, Kjong Van-Lehmann, André Khales, Tinu Thomas, Cornelia Schwerdel, Nicola Aceto, Gunnar Rätsch, M. Stoffel, Gerald Schwank   +12 more
semanticscholar   +6 more sources

The metabolic reprogramming and vulnerability of SF3B1 mutations [PDF]

Molecular & Cellular Oncology, 2020
Mutations in the splicing factor 3b subunit 1 (SF3B1) gene create a neomorphic protein that disrupts RNA splicing, but the downstream consequences of this missplicing are unclear.
W. Brian Dalton
doaj   +4 more sources

The biological function and clinical significance of SF3B1 mutations in cancer [PDF]

Biomarker Research, 2020
Spliceosome mutations have become the most interesting mutations detected in human cancer in recent years. The spliceosome, a large, dynamic multimegadalton small nuclear ribonucleoprotein composed of small nuclear RNAs associated with proteins, is ...
Zhixia Zhou, Qi Gong, Yin Wang, Mengkun Li, Lu Wang, Hongfei Ding, Peifeng Li   +6 more
doaj   +4 more sources

Chronic myelomonocytic leukemia with ring sideroblasts/SF3B1 mutation presents with low monocyte count and resembles myelodysplastic syndromes with-RS/SF3B1 mutation in terms of phenotype and prognosis

Frontiers in Oncology
IntroductionChronic myelomonocytic leukemia (CMML) and myelodysplastic syndromes (MDS) with ring sideroblasts (RS) or SF3B1 mutation (MDS-RS/SF3B1) differ in many clinical features, but share others, such as anemia.
Blanca Xicoy, Helena Pomares, Mireia Morgades, Ulrich Germing, Montserrat Arnan, Mar Tormo, Laura Palomo, Elisa Orna, Matteo Della Porta, Felicitas Schulz, Marina Díaz-Beya, Ada Esteban, Antonieta Molero, Luca Lanino, Alejandro Avendaño, Francisca Hernández, Verónica Roldan, Marta Ubezio, Alberto Pineda, María Díez-Campelo, Lurdes Zamora   +20 more
doaj   +2 more sources

Inhibition of SF3B1 improves the immune microenvironment through pyroptosis and synergizes with αPDL1 in ovarian cancer

Cell Death and Disease, 2023
Ovarian cancer is resistant to immune checkpoint blockade (ICB) treatment. Combination of targeted therapy and immunotherapy is a promising strategy for ovarian cancer treatment benefit from an improved immune microenvironment.
Shourong Wang, Yao Liu, Huimin Xiao, Zhongshao Chen, Xiaohang Yang, Jingjing Yin, Yingwei Li, Cunzhong Yuan, Shi Yan, Gang Chen, Qinglei Gao, Beihua Kong, Chaoyang Sun, Kun Song   +13 more
doaj   +2 more sources

Prognostic impact of SF3B1 mutation and multilineage dysplasia in myelodysplastic syndromes with ring sideroblasts: a Mayo Clinic study of 170 informative cases

Haematologica
The revised 4th edition of the World Health Organization (WHO4R) classification lists myelodysplastic syndromes with ring sideroblasts (MDS-RS) as a separate entity with single lineage (MDS-RS-SLD) or multilineage (MDS-RS-MLD) dysplasia. The more recent
Faiqa Farrukh, Maymona Abdelmagid, Abhishek Mangaonkar, Mrinal Patnaik, Aref Al-Kali, Michelle A. Elliott, Kebede H. Begna, Christopher C. Hook, William J. Hogan, Animesh Pardanani, Mark R. Litzow, Rhett P. Ketterling, Naseema Gangat, Daniel A. Arber, Attilio Orazi, Rong He, Kaaren Reichard, Ayalew Tefferi   +17 more
doaj   +2 more sources

Studying the connection between SF3B1 and four types of cancer by analyzing networks constructed based on published research

Scientific Reports, 2023
Splicing factor 3B subunit 1 (SF3B1) is the largest component of SF3b protein complex which is involved in the pre-mRNA splicing mechanism. Somatic mutations of SF3B1 were shown to be associated with aberrant splicing, producing abnormal transcripts that
Asmaa Samy, Mehmet Kemal Ozdemir, Reda Alhajj   +2 more
doaj   +2 more sources

Accelerated DNA replication fork speed due to loss of R-loops in myelodysplastic syndromes with SF3B1 mutation

Nature Communications
Myelodysplastic syndromes (MDS) with mutated SF3B1 gene present features including a favourable outcome distinct from MDS with mutations in other splicing factor genes SRSF2 or U2AF1. Molecular bases of these divergences are poorly understood.
David Rombaut, Carine Lefèvre, Tony Rached, Sabrina Bondu, Anne Letessier, Raphael M. Mangione, Batoul Farhat, Auriane Lesieur-Pasquier, Daisy Castillo-Guzman, Ismael Boussaid, Chloé Friedrich, Aurore Tourville, Magali De Carvalho, Françoise Levavasseur, Marjorie Leduc, Morgane Le Gall, Sarah Battault, Marie Temple, Alexandre Houy, Didier Bouscary, Lise Willems, Sophie Park, Sophie Raynaud, Thomas Cluzeau, Emmanuelle Clappier, Pierre Fenaux, Lionel Adès, Raphael Margueron, Michel Wassef, Samar Alsafadi, Nicolas Chapuis, Olivier Kosmider, Eric Solary, Angelos Constantinou, Marc-Henri Stern, Nathalie Droin, Benoit Palancade, Benoit Miotto, Frédéric Chédin, Michaela Fontenay   +39 more
doaj   +2 more sources

The Impact of Spliceosome Inhibition in SF3B1-Mutated Uveal Melanoma. [PDF]

Invest Ophthalmol Vis Sci
Purpose Unfortunately, treatment of patients with uveal melanoma (UM) with metastatic disease is limited. Twenty percent of patients with UM harbor a mutation in the splicing factor gene SF3B1, suggesting that aberrant spliceosome function plays a vital ...
Nguyen JQN, Drabarek W, Leeflang AMCHJ, Brands T, van den Bosch TPP, Verdijk RM, van de Werken HJG, van Riet J, Paridaens D, de Klein A, Brosens E, Kiliç E, Rotterdam Ocular Melanoma Study Group.   +12 more
europepmc   +5 more sources

Expression of circular RNAs in myelodysplastic neoplasms and their association with mutations in the splicing factor gene SF3B1

Molecular Oncology, 2023
Mutations in the splicing factor 3b subunit 1 (SF3B1) gene are frequent in myelodysplastic neoplasms (MDS). Because the splicing process is involved in the production of circular RNAs (circRNAs), we investigated the impact of SF3B1 mutations on circRNA ...
Iva Trsova, Andrea Hrustincova, Zdenek Krejcik, David Kundrat, Aleš Holoubek, Karolina Staflova, Lucie Janstova, Sarka Vanikova, Katarina Szikszai, Jiri Klema, Petr Rysavy, Monika Belickova, Monika Kaisrlikova, Jitka Vesela, Jaroslav Cermak, Anna Jonasova, Jiri Dostal, Jan Fric, Jan Musil, Michaela Dostalova Merkerova   +19 more
doaj   +2 more sources