Results 11 to 20 of about 4,025 (237)

Antibody production and characterization of the nucleoprotein of sever fever with thrombocytopenia syndrome virus (SFTSV) for effective diagnosis of SFTSV

Virology Journal, 2023
Background Severe fever with thrombocytopenia syndrome (SFTS) is an infectious disease caused by the Dabie bandavirus, [or SFTS virus (SFTSV)] that has become increasingly widespread since it was first reported in 2009.
Kyungha Lee, Min Ji Choi, Man-Ho Cho, Dong Ok Choi, Seong-Hee Bhoo   +4 more
doaj   +4 more sources

The hnRNP A2B1 is important for the replication of SFTSV and other RNA viruses

Microbiology Spectrum
The heterogeneous nuclear ribonucleoprotein (hnRNP A2B1) is a key component of the hnRNP complex involving RNA modulation in eukaryotic cells and it has also been reported to be involved in the replication of the hepatitis E virus, influenza A virus, and
Xu Zhang, Lina Yan, Bin-Yan Liu, Chuan‐Min Zhou, Xue-Jie Yu   +4 more
semanticscholar   +5 more sources

Inhibition of SFTSV replication in humanized mice by a subcutaneously administered anti-PD1 nanobody

EMBO Molecular Medicine
Severe fever with thrombocytopenia syndrome (SFTS) is a life-threatening disease caused by a novel bunyavirus (SFTSV), mainly transmitted by ticks. With no effective therapies or vaccines available, understanding the disease’s mechanisms is crucial ...
Mengmeng Ji, J L Hu, Doudou Zhang, Bilian Huang, Shijie Xu, Na Jiang, Yuxin Chen, Yujiong Wang, Xilin Wu, Zhiwei Wu   +9 more
semanticscholar   +5 more sources

SFTSV infection is associated with transient overproliferation of monoclonal lambda-type plasma cells [PDF]

iScience, 2023
The impairment of antibody-mediated immunity is a major factor associated with fatal cases of severe fever with thrombocytopenia syndrome (SFTS). By collating the clinical diagnosis reports of 30 SFTS cases, we discovered the overproliferation of monoclonal plasma cells (MCP cells, CD38+cLambda+cKappa-) in bone marrow, which has only been reported ...
Chuansong Quan, Qinghua Liu, Lijuan Yu, Chunjing Li, Kaixiao Nie, Guoyong Ding, Hong Zhou, Xinli Wang, Wenwen Sun, Huiliang Wang, Maokui Yue, Wei Li, Wenjun Zheng, Qiang Lyu, Weijia Xing, Zhenjie Zhang, Michael J. Carr, Hong Zhang, Weifeng Shi   +18 more
semanticscholar   +5 more sources

Seasonal dynamics of Haemaphysalis tick species as SFTSV vectors in South Korea

Microbiology Spectrum
Ticks pose a significant public health threat due to their ability to transmit various pathogens, including emerging tick-borne diseases. This study conducted a comprehensive surveillance of Haemaphysalis tick species and their severe fever with ...
Hyunwoo Jang, Mark Anthony B. Casel, Seung‐Gyu Jang, Jeong Ho Choi, Juryeon Gil, Rare Rollon, So youn Cheun, Young‐Il Kim, Min‐Suk Song, Young Ki Choi   +9 more
semanticscholar   +5 more sources

Molecular mechanism and structure-guided humanization of a broadly neutralizing antibody against SFTSV.

PLoS Pathogens
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a novel tick-borne bunyavirus that causes severe fever with thrombocytopenia syndrome (SFTS), with a high mortality rate of up to 30%.
Pinyi Yang, Xiaoli Wu, Hang Shang, Zixian Sun, Zhiying Wang, Zidan Song, Hong Yuan, Fei Deng, Shu Shen, Yu Guo, Nan Zhang   +10 more
doaj   +4 more sources

SFTSV NSs interacts with AGO2 to regulate the RNAi pathway for viral replication. [PDF]

J Virol
ABSTRACT RNA interference (RNAi) is a posttranscriptional gene silencing mechanism acting as an antiviral defense in eukaryotes. During viral replication, intermediate double-stranded RNAs are processed into virus-derived small interfering RNAs (vsiRNAs) by the host enzyme, DICER.
Javaid N, Jang T-W, Fu Y, Choi Y.
europepmc   +4 more sources

The cap-snatching SFTSV endonuclease domain is an antiviral target [PDF]

Cell Reports, 2020
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a tick-borne virus with 12%-30% case mortality rates and is related to the Heartland virus (HRTV) identified in the United States.
Amarasinghe, Gaya K, Bowman, Gregory R, Choi, Younho, Frederick, Thomas E, Gross, Michael L, Jung, Jae U, Leung, Daisy W, Shin, Woo-Jin, Wang, Wenjie, Yoo, Ji-Seung, Zhang, Bojie, Zimmerman, Maxwell I   +11 more
core   +8 more sources

Characterization of severe fever with thrombocytopenia syndrome in rural regions of Zhejiang, China. [PDF]

PLoS ONE, 2014
Severe fever with thrombocytopenia syndrome virus (SFTSV) infections have recently been found in rural regions of Zhejiang. A severe fever with thrombocytopenia syndrome (SFTS) surveillance and sero-epidemiological investigation was conducted in the ...
Lei Zhang, Ling Ye, David M Ojcius, Xiuyu Lou, Chengwei Wang, Cen feng, Yi Sun, Zhongfa Wang, Shibo Li, Yanjun Zhang   +9 more
doaj   +12 more sources

Hedgehogs as Amplifying Hosts of Severe Fever with Thrombocytopenia Syndrome Virus, China [PDF]

Emerging Infectious Diseases, 2022
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a tickborne bandavirus mainly transmitted by Haemaphysalis longicornis ticks in East Asia, mostly in rural areas.
Chaoyue Zhao, Xing Zhang, Xiaoxi Si, Ling Ye, Kevin Lawrence, Yajun Lu, Chunhong Du, Haidong Xu, Qian Yang, Qianfeng Xia, Guoxiang Yu, Wei Xu, Fei Yuan, Junfeng Hao, Jia-Fu Jiang, Aihua Zheng   +15 more
doaj   +3 more sources