Results 11 to 20 of about 3,555 (225)

Recent Advances in Humoral Immunity Dysregulation in Severe Fever With Thrombocytopenia Syndrome Virus (SFTSV) Infection: A Systematic Review. [PDF]

Health Sci Rep
ABSTRACT Background and Aims Severe fever with thrombocytopenia syndrome virus (SFTSV) infection causes profound dysregulation of humoral immunity, leading to immunopathology and impaired viral clearance. However, the mechanisms underlying B cell dysfunction and inadequate antibody responses remain poorly defined.
Hou H, Yuan X, Chen R, Xiong Z, Wu S, Wang F.   +5 more
europepmc   +4 more sources

Investigation into the Pancreatic Pathogenesis of SFTSV across Multiple Levels. [PDF]

Adv Sci (Weinh)
A retrospective analysis revealed that 17.6% of severe fever with thrombocytopenia syndrome (SFTS) patients met the diagnostic criteria for clinically confirmed pancreatitis. Using human pancreatic organoids and murine models demonstrated that SFTSV exhibits a specific pancreatic tropism, leading to cell death and initiating a strong inflammatory ...
Liu X, Xu Z, Tong Y, Wang C, Yao Y, Diao Y, Ma J, Zhou S, Du Y, Zhang Z, Xu G.   +10 more
europepmc   +3 more sources

Novel SFTSV Phylogeny Reveals New Reassortment Events and Migration Routes [PDF]

Virologica Sinica, 2020
Severe fever with thrombocytopenia syndrome virus (SFTSV), the causative agent of a febrile human disease, was first identified from central and eastern provinces in China, and later in Japan and South Korea. Hubei Province is one of the major SFTS epidemic areas in the central part of China.
Xiaoli Wu, Mingyue Li, Yanfang Zhang, Boyun Liang, Junming Shi, Yaohui Fang, Zhèngyuán Sū, Mengmeng Li, Wenjing Zhang, Ling Xu, Jun Wang, Qiaoli Wu, Shuāng Táng, Huálín Wáng, Tao Zhang, Cheng Peng, Xin Zheng, Fēi Dèng, Shū Shěn   +18 more
openalex   +4 more sources

Antibody production and characterization of the nucleoprotein of sever fever with thrombocytopenia syndrome virus (SFTSV) for effective diagnosis of SFTSV

Virology Journal, 2023
Background Severe fever with thrombocytopenia syndrome (SFTS) is an infectious disease caused by the Dabie bandavirus, [or SFTS virus (SFTSV)] that has become increasingly widespread since it was first reported in 2009.
Kyungha Lee, Min Ji Choi, Man-Ho Cho, Dong Ok Choi, Seong-Hee Bhoo   +4 more
doaj   +3 more sources

SFTSV Infection Induced Interleukin-1β Secretion Through NLRP3 Inflammasome Activation [PDF]

Frontiers in Immunology, 2021
Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne virus that causes hemorrhagic fever. Previous studies showed that SFTSV-infected patients exhibited elevated levels of pro-inflammatory cytokines like interleukin-1β (IL ...
Jian-Wei Liu, Min Chu, Yong-jun Jiao, Chuan-Min Zhou, Rui Qi, Xue-jie Yu   +5 more
doaj   +3 more sources

An orally available 4<i>'</i>-fluorouridine prodrug inhibits SFTSV and LCMV infection. [PDF]

J Virol
ABSTRACT Bunyaviruses, a subset of segmented negative-sense RNA viruses, include pathogenic species capable of zoonotic transmission to humans via arthropod vectors and rodent hosts.
Jian X, Hu T, Xu H, Wen Y, Zhang Y, Xu M, Jiang X, Cao J, Xiang L, Shen J, Tian G, Xiao G, Zhang L.   +12 more
europepmc   +4 more sources

The cap-snatching SFTSV endonuclease domain is an antiviral target [PDF]

Cell Reports, 2020
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a tick-borne virus with 12%-30% case mortality rates and is related to the Heartland virus (HRTV) identified in the United States.
Amarasinghe, Gaya K, Bowman, Gregory R, Choi, Younho, Frederick, Thomas E, Gross, Michael L, Jung, Jae U, Leung, Daisy W, Shin, Woo-Jin, Wang, Wenjie, Yoo, Ji-Seung, Zhang, Bojie, Zimmerman, Maxwell I   +11 more
core   +7 more sources

An emerging hemorrhagic fever in China caused by a novel bunyavirus SFTSV [PDF]

Science China Life Sciences, 2013
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic fever in rural areas of China and is caused by a new bunyavirus, SFTSV, named after the disease. The transmission vectors and animal hosts of SFTSV are unclear. Ticks are the most likely transmission vectors and domestic animals, including goats, dogs, and cattle, are ...
XiaoShuang Zhang, Yan Liu, Li Zhao, Bing Li, Hao Yu, Hongling Wen, Xue‐jie Yu   +6 more
openalex   +3 more sources

Identification and characterization of three monoclonal antibodies targeting the SFTSV glycoprotein and displaying a broad spectrum recognition of SFTSV-related viruses

PLOS Neglected Tropical Diseases
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a novel tick-borne viral pathogen that causes severe fever with thrombocytopenia syndrome (SFTS). The disease was initially reported in central and eastern China, then later in Japan and South Korea, with a mortality rate of 13–30%.
Xiaoli Wu, Abulimiti Moming, Yanfang Zhang, Zhi Wang, Tao Zhang, Liyan Fu, Jin Qian, Jun Ni, Sijing Hu, Shuāng Táng, Xin Zheng, Huálín Wáng, Shū Shěn, Fēi Dèng   +13 more
openalex   +4 more sources

Bunyavirus SFTSV nucleoprotein exploits TUFM-mediated mitophagy to impair antiviral innate immunity [PDF]

Autophagy
Severe fever with thrombocytopenia syndrome is an emerging viral hemorrhagic fever caused by a tick-borne bunyavirus, severe fever with thrombocytopenia syndrome virus (SFTSV), with a high case fatality. We previously found that SFTSV nucleoprotein (NP) induces macroautophagy/autophagy to facilitate virus replication.
Wenkang Zhang, Jiamin Yan, Chu Min, Bang Li, Xiaolan Gu, Zezheng Jiang, Zemin Li, Panpan Liu, Tian-Mei Yu, Chuan‐Min Zhou, Xue-Jie Yu   +10 more
openalex   +3 more sources