Results 21 to 30 of about 4,025 (237)

Decoding broadly neutralizing antibodies: a milestone in SFTSV therapy. [PDF]

EBioMedicine
Zhao X, Chu H.
europepmc   +5 more sources

SAFA initiates innate immunity against cytoplasmic RNA virus SFTSV infection

PLoS Pathogens, 2021
Nuclear scaffold attachment factor A (SAFA) is a novel RNA sensor involved in sensing viral RNA in the nucleus and mediating antiviral immunity. Severe fever with thrombocytopenia syndrome virus (SFTSV) is a bunyavirus that causes SFTS with a high ...
Bin-yan Liu, Xue-jie Yu, Chuan-min Zhou
doaj   +5 more sources

Interaction between the SFTSV envelope glycoprotein Gn and STING inhibits the formation of the STING-TBK1 complex and suppresses the NF-κB signaling pathway

Journal of Virology
Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne bunyavirus with high pathogenicity. There has been a gradual increase in the number of reported cases in recent years, with high morbidity and mortality rates. The cyclic
Yupei Jia, Feifei Li, Zixiang Liu, Sihua Liu, Mengqian Huang, Xiaoning Gao, Xin Su, Zhiyun Wang, Tao Wang   +8 more
openalex   +2 more sources

The immunogenicity and protection efficacy evaluation of mRNA vaccine candidate for severe fever with thrombocytopenia syndrome in mice. [PDF]

PLoS Neglected Tropical Diseases
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a tick-borne viral pathogen that causes Severe fever with thrombocytopenia syndrome (SFTS) in humans with a high fatality rate.
Da-Eun Jeong, Jack Yoon, Baek Kim, Jun-Gu Kang   +3 more
doaj   +2 more sources

Current Progress of Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) Vaccine Development [PDF]

Viruses
SFTSV is an emerging tick-borne virus causing hemorrhagic fever with a case fatality rate (CFR) that can reach up to 27%. With endemic infection in East Asia and the recent spread of the vector tick to more than 20 states in the United States, the SFTSV ...
Do-Kyun Kim, Chih‐Jen Lai, In‐Ho Cha, Jae U. Jung   +3 more
openalex   +2 more sources

Adenovirus type 5-expressing Gn induces better protective immunity than Gc against SFTSV infection in mice

npj Vaccines
Severe fever with thrombocytopenia syndrome (SFTS) is caused by the SFTS virus (SFTSV) with high morbidity and mortality. The major immunodominant region of SFTSV surface glycoprotein (G) remains unclear.
Hua Qian, Li Tian, Wenkai Liu, Lele Liu, Menghua Li, Zhongxin Zhao, Xiaoying Lei, Wenwen Zheng, Zhongpeng Zhao, Xuexing Zheng   +9 more
doaj   +2 more sources

Discovery of novel Favipiravir derivatives with improved pharmacokinetic properties as anti-SFTSV agents

European Journal of Medicinal Chemistry Reports
Favipiravir is a nucleobase analogue that exhibits antiviral activities against a variety of RNA viruses. Due to the lack of antivirals to combat SFTS, an emerging tickborne epidemic caused by a RNA virus belonging to the Phenuividae family within Bunyavirales, Favipiravir has been put brand new attention as optimal SFTS clinical candidate.
Xiaomeng He, Fan Wu, Wei Li, Runze Zhang, Ruiyang Sun, Zhìhóng Hú, Wu Zhong, Manli Wang   +7 more
semanticscholar   +4 more sources

SFTSV nucleoprotein mediates DNA sensor cGAS degradation to suppress cGAS-dependent antiviral responses

Microbiology Spectrum
Cyclic GMP-AMP synthase (cGAS) is an important DNA pattern recognition receptor that senses double-stranded DNA derived from invading pathogens or self DNA in cytoplasm, leading to an antiviral interferon response.
Ze-zheng Jiang, Min Chu, Li-na Yan, Wen-kang Zhang, Bang Li, Jiao Xu, Zhong-xin Zhao, Hui-Ju Han, Chuan-min Zhou, Xue-jie Yu   +9 more
doaj   +2 more sources

Knockout of CLTC gene reduces but not completely block SFTSV infection

PLOS ONE, 2023
Clathrin is a key protein for viruses to enter host cells. Previous studies often use clathrin inhibitors or gene knockdown technology to partially inhibit the function of clathrin, but whether SFTSV can infect host cells without clathrin expression ...
Tiezhu Liu, Jiajia Li, Xueqi Wang, Tao Huang, Wei Wu, Aqian Li, Chuan Li, Xiaoxia Huang, Qin Wang, De-xin Li, Shiwen Wang, M. Liang   +11 more
semanticscholar   +4 more sources

Bispecific antibodies targeting two glycoproteins on SFTSV exhibit synergistic neutralization and protection in a mouse model

Proceedings of the National Academy of Sciences of the United States of America
Significance Severe fever with thrombocytopenia syndrome virus (SFTSV) is one of the bunyaviruses that caused severe clinical symptoms with a mortality rate ranging from 5 to 30%.
Zhen Chang, Dan Gao, Liying Liao, Junqing Sun, Gen Zhang, Xue Zhang, Feiran Wang, Chunrui Li, Babayemi Olawale Oladejo, Shihua Li, Yan Chai, Yongfei Hu, Xuancheng Lu, Haixia Xiao, Jianxun Qi, Zhihai Chen, Feng Gao, Yan Wu   +17 more
openalex   +2 more sources