Results 61 to 70 of about 47,342 (264)
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Penumbra Shadow Representation in Photovoltaics: Comparing Dynamic and Constant Intensity
Applied SciencesThis study is the first to directly compare natural dynamic penumbra shadows with experimentally replicated constant-intensity shadows on photovoltaic modules, providing new insights into the limitations of conventional shadow approximations found in the
Matthew Axisa +2 more
doaj +1 more source
Single image shadow removal by optimization using non-shadow anchor values
Computational Visual Media, 2019 Shadow removal has evolved as a pre-processing step for various computer vision tasks. Several studies have been carried out over the past two decades to eliminate shadows from videos and images. Accurate shadow detection is an open problem because it is
Saritha Murali +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Perception of shadows in children with autism spectrum disorders.
PLoS ONE, 2010 BackgroundCast shadows in visual scenes can have profound effects on visual perception. Much as they are informative, they also constitute noise as they are salient features of the visual scene potentially interfering with the processing of other ...
Cristina Becchio +2 more
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Remote Sensing, 2019 Up-to-date 3D city models are needed for many applications. Very-high-resolution (VHR) images with rich geometric and spectral information and a high update rate are increasingly applied for the purpose of updating 3D models.
Kaixuan Zhou +2 more
doaj +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
L’Enseignement Mathématique, 2019 Moser's shadow problem asks to estimate the shadow function \mathfrak s_b(n) , which is the largest number such that for each bounded convex polyhedron P with
Lagarias, Jeffrey C. +2 more
openaire +2 more sources