Results 21 to 30 of about 47,367 (336)

Combined shake-flask, chromatographic and in silico approaches for evaluating the physicochemical and ADME properties of aloin A and aloe-emodin

open access: goldActa Pharmaceutica
Aloe vera has a long history of medicinal use due to its diverse biological activities, including antioxidant, anti-inflammatory and antimicrobial. This study investigates the physicochemical and ADME (absorption, distribution, metabolism, excretion ...
Klarić Daniela Amidžić   +6 more
doaj   +2 more sources

High cell density cultivation of Bacillus subtilis NCIM 2063: Modeling, optimization and a scale-up procedure [PDF]

open access: yesJournal of the Serbian Chemical Society, 2023
Bacillus subtilis is a non-pathogenic, sporulating, Gram-positive bacteria with pronounced antimicrobial and metabolic activity and great potential for wide application in various fields. The aim of this paper was to determine the optimum B.
Stamenković-Stojanović Sandra   +4 more
doaj   +1 more source

Effects of experimental conditions on solubility measurements for BCS classification in order to improve the biowaiver guidelines

open access: yesBrazilian Journal of Pharmaceutical Sciences, 2021
Among the methods described for determining the solubility, shake-flask is suitable to evaluate the equilibrium solubility according to the BCS. Nevertheless, experimental conditions related to the shake-flask method are not well described.
Patrícia Fernanda Monteiro   +5 more
doaj   +1 more source

Metabolic Transformation and Fermentation Condition of L-homoserine Synthesis by Corynebacterium glutamicum

open access: yesShipin gongye ke-ji, 2023
Objective: In this study, Corynebacterium glutamicum ATCC 13032 was used as the chassis cell for synthesizing L-homoserine and analyzing the effect of dissolved oxygen on product synthesis. Methods: First, the product tolerance of C.
Qiushuang GUO   +6 more
doaj   +1 more source

Bioleaching of chalcopyrite using native Acidithiobacillus ferrooxidans isolated in a mining area in Kitwe Zambia

open access: yesScientific African, 2023
This study aimed to assess the influence of the physical-chemical factors (particle size, shake flask speed, starting pH, and pulp density) in bioleaching of Zambian chalcopyrite using a novel native isolated Acidithiobacillus ferrooxidans strain DJN1 ...
Davis John Nangali   +7 more
doaj   +1 more source

Levan Production in Shake Flask and Fermenter Influence of Feeding Strategy on Levan Yield and Molecular Weight Distribution [PDF]

open access: yesE3S Web of Conferences, 2023
Effect of feeding strategy on levan production was studied in a shake flask and a 5 L lab scale fermenter. In a shake flask, levan specific substrate yield (YP/S) increased from 0.35 g levan/g sucrose to 0.48 g levan/g sucrose with repeated batch feeding.
Veerapandian Bhuvaneshwari   +5 more
doaj   +1 more source

Breeding of a High-Yield Glutathione-Producing Strain by Atmospheric and Room Temperature Plasma Mutagenesis and Microbial Microdroplet Culture System [PDF]

open access: yesShipin Kexue, 2023
In order to improve the ability of a wild-type strain (BY-1) of Pichia pastoris to produce glutathione (GSH), a mutant strain designated BY-1-26 was obtained by atmospheric and room temperature plasma (ARTP) mutagenesis. To further improve the production
LING Siyu, WANG Zhou, ZHANG Huimin, LI Chuang, LIU Qingtao, LIU Yan, XUE Zhenglian
doaj   +1 more source

Enhanced Phenazine-1-Carboxamide Production in Pseudomonas chlororaphis H5△fleQrelA through Fermentation Optimization

open access: yesFermentation, 2022
Phenazine-1-carboxamide (PCN) is effective to control many plant pathogens, and improving PCN production would be of great significance in promoting its development as a biopesticide.
Jiajia Cui   +4 more
doaj   +1 more source

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