Results 81 to 90 of about 3,495,060 (298)
Generative urban design using shape grammar and block morphological analysis
Frontiers of Architectural Research, 2020 The significant challenges that urban design faces when moving forward into this new digital era involve the increasingly massive and complex projects that must be analyzed and developed.
Xiao Wang, Yacheng Song, Peng Tang
doaj +1 more source
Performance of profiled single noise barriers covered with quadratic residue diffusers [PDF]
, 2005 The paper describes an investigation about the acoustic performance of noise barriers with quadratic residue diffuser (QRD) tops, and with T-, Arrow-, Cylindrical and Y-shape profiles.
Lam, YW, Monazzam, M
core +2 more sources
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Shape design optimization of 2-dimensional inlaid structures
Nihon Kikai Gakkai ronbunshu, 2016 Owning to the different mechanical behaviors of the instinct materials, inlaid structures composed of dissimilar materials have potential for industrial application, such as vibration suppression.
Masatoshi SHIMODA +2 more
doaj +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Design modeling for shape optimization [PDF]
Some important aspects of design modeling for shape optimization are discussed for both stamped sheet metal components and cast solid components. For stamped components the basis for the modeling approach is a boundary design function.
Botkin, M. E.
core +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Inside the Construction Operating Theater at SECCM Labs [PDF]
, 2018 Shawmut Design & Construction welcomes students on-site to observe and dissect the construction process as the new laboratories building takes ...
Rodrigues, Jill, Wilder, Justin
core +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source