Results 91 to 100 of about 1,014,609 (340)
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Polygons as optimal shapes with convexity constraint
, 2009 In this paper, we focus on the following general shape optimization problem: $$ \min\{J(\Om), \Om convex, \Om\in\mathcal S_{ad}\}, $$ where $\mathcal S_{ad}$ is a set of 2-dimensional admissible shapes and $J:\mathcal{S}_{ad}\to\R$ is a shape functional.
Lamboley, Jimmy, Novruzi, Arian
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Journal of Interdisciplinary Studies in Education, 2019 The present study investigated our hypothesis of an underlying relationship between optimism/pessimism and implicit theories of intelligence. We investigated the psychometric properties of optimism and mindset scales in our sample, compared confirmatory factor analysis models of the scales, examined the full measurement model to
William R. Dardick +1 more
openaire +1 more source
A Discretize-then-Optimize Approach to PDE-Constrained Shape Optimization
, 2023 Roland Herzog, Estefanía Loayza-Romero
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Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Design modeling for shape optimization [PDF]
Some important aspects of design modeling for shape optimization are discussed for both stamped sheet metal components and cast solid components. For stamped components the basis for the modeling approach is a boundary design function.
Botkin, M. E.
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Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Shape optimization method for nozzle design
Computer Assisted Methods in Engineering and Science, 2023 The optimization of the nozzle shape was carried out using the finite element incompressible viscous flow solver, with discretization of total derivative, with the originally developed software.
Zoran Mrša, Gorazd Medić
doaj
On symmetry and asymmetry in a problem of shape optimization [PDF]
, 2012 Alexander I. Nazarov
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