Results 81 to 90 of about 994,929 (290)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Proposal of texture shape optimization algorithm under constant load condition and considerations on new shape update equation (Texture shape optimization for minimization of friction coefficient)

Journal of Fluid Science and Technology, 2020
An algorithm to optimize texture shape under constant load conditions and a shape update equation of the design variables are proposed. The tribological properties are improved by machining grooves and holes, termed“ texture ”, on frictional surfaces ...
Syuta SASAOKA, Takahiko KURAHASHI
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Polygons as optimal shapes with convexity constraint

, 2009
In this paper, we focus on the following general shape optimization problem: $$ \min\{J(\Om), \Om convex, \Om\in\mathcal S_{ad}\}, $$ where $\mathcal S_{ad}$ is a set of 2-dimensional admissible shapes and $J:\mathcal{S}_{ad}\to\R$ is a shape functional.
Lamboley, Jimmy, Novruzi, Arian
core   +3 more sources

On a classical spectral optimization problem in linear elasticity

, 2014
We consider a classical shape optimization problem for the eigenvalues of elliptic operators with homogeneous boundary conditions on domains in the $N$-dimensional Euclidean space.
B Kawohl, D Bucur, D Bucur, D Buoso, D Buoso, D Mazzoleni, E Oudet, G Buttazzo, J Serrin, K Deimling, LM Chasman, MS Ashbaugh, NS Nadirashvili, P Grinfeld, PD Lamberti, PD Lamberti, PD Lamberti, PD Lamberti, SA Wolf   +18 more
core   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Reconstruction of Tesla micro-valve using topological sensitivity analysis

Advances in Nonlinear Analysis, 2019
In this paper, we deal with topology optimization attributed to the non stationary Navier-Stokes equations. We propose an approach where we analyze the sensitivity of a shape function relating to a perturbation of the flow domain.
Abdelwahed M., Chorfi N., Malek R.
doaj   +1 more source

Shape optimization of phononic band gap structures using the homogenization approach

, 2017
The paper deals with optimization of the acoustic band gaps computed using the homogenized model of strongly heterogeneous elastic composite which is constituted by soft inclusions periodically distributed in stiff elastic matrix.
Heczko, Jan, Rohan, Eduard, Vondřejc, Jaroslav   +2 more
core   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source