Results 111 to 120 of about 871,984 (313)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Efficient handling of stability problems in shell optimization by asymmetric ‘worst-case’ shape imperfection [PDF]

, 2008
The paper presents an approach to shape optimization of proportionally loaded elastic shell structures under stability constraints. To reduce the stability-related problems, a special technique is utilized, by which the response analysis is always ...
Brank, Boštjan, Kegl, Marko, Harl, Branko, Oblak, Maks   +3 more
core   +1 more source

Presentation of representative shape parameters of porous media based on mathematical computation on images

Energy Exploration & Exploitation
The shape parameters of porous media are really important to describe the petrophysical and geomechanical parameters of reservoirs. In addition, shape analysis can provide essential information about the origin, transport, deposition history of particles,
Mina Shafiabadi, Manouchehr Sanei, Amin Hekmatnejad, Seyed-Mousa Sajadi   +3 more
doaj   +1 more source

The Influence of Shape Parameters on Unidirectional Drug Release from 3D Printed Implants and Prediction of Release from Implants with Individualized Shapes. [PDF]

Pharmaceutics, 2023
Domsta V, Hänsch C, Lenz S, Gao Z, Matin-Mann F, Scheper V, Lenarz T, Seidlitz A.   +7 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Measuring Shape Parameters of Pearls in Batches Using Machine Vision: A Case Study. [PDF]

Micromachines (Basel), 2022
Liu X, Jin S, Yang Z, Królczyk G, Li Z.
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

A Simple Gamma Random Number Generator for Arbitrary Shape Parameters [PDF]

This paper proposes an improved gamma random generator. In the past, a lot of gamma random number generators have been proposed, and depending on a shape parameter (say, alpha) they are roughly classified into two cases: (i) alpha lies on the interval (0,
Hisashi Tanizaki
core  

Lightning current wave shape parameters.

, 2019
Lightning current wave shape parameters.
M. A. M. Radzi (4452457), M. Izadi (6944879), N. H. Zaini (6944885), M. Z. A. Ab-Kadir (6944876), N. I. Ahmad (6944882), M. S. M. Nasir (6944873)   +5 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source