Results 131 to 140 of about 871,984 (313)
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Wind Energy Potential Assessment for Nooriabad Sindh Pakistan
International Journal of Economic and Environment Geology, 2020 Wind speeds recorded at regular intervals of time for a particular wind site correspond to intermittent source of energy. Reliable estimate of wind potential for the site requires fitting of the recorded data to a continuous distribution
Muhammad Shoaib, Imran Siddiqui, Saif ur Rehman, Ibrahim Zia
doaj
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
, 2015 Original image is binarized and skeletonized. Four shape parameters are calculated. Worm length is the length of the midline; worm thickness is defined as worm area divided by worm length; R1 and R2 are the ratios of worm diameters at two specific ...
Zheng Liu (28397) +4 more
core +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
, 2018 The penetration performance of projectiles is closely related to their nose shape as it influences the kinetic energy penetration of a rigid projectile. One new type of projectile, which is entitled U-shape-nose grooved projectile, is introduced in this ...
Jiajie Deng (5362262) +3 more
core +1 more source
ESTIMATION OF HUMAN BODY SHAPE PARAMETERS USING MICROSOFT KINECTSENCOR
Informatika, 2017 In the paper a human body shape estimation technology based on scan data acquired from sensor controller Microsoft Kinect is described. This device includes an RGB camera and a depth sensor that provides, for each pixel of the image,a distance from the ...
D. M. Vasilkov
doaj
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
, 2012 Chul-Young Bae,1 Young Gon Kang,2 Young-Sung Suh,3 Jee Hye Han,4 Sung-Soo Kim,5 Kyung Won Shim61MediAge Research Center, Seoul, Korea; 2Chaum Power Aging Center, College of Medicine, CHA University, Seoul, Korea; 3Health Promotion Center, Keimyung ...
Kim SS +5 more
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