Results 141 to 150 of about 6,626,969 (302)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

Statistical shape analysis for bio-structures : local shape modelling, techniques and applications [PDF]

open access: yes
A Statistical Shape Model (SSM) is a statistical representation of a shape obtained from data to study variation in shapes. Work on shape modelling is constrained by many unsolved problems, for instance, difficulties in modelling local versus global ...
Valdés Amaro, Daniel Alejandro
core  

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

Sex differences in the three-dimensional morphology of unruptured intracranial aneurysms

open access: yesNeuroImage: Reports
Objective: Women have a higher rupture risk of intracranial aneurysms than men. One possible explanation is that aneurysm volume and shape irregularity, both linked to rupture risk, may differ between women and men.
Maarten J. Kamphuis   +9 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani   +9 more
wiley   +1 more source

Efficient Shape Retrieval Using Elliptical Shape Coding [PDF]

open access: yes, 2009
[[abstract]]This paper presents a novel shape representation, called elliptical shape coding, and uses it to develop an efficient shape retrieval algorithm.
WEI-YANG LIN;JIA-MING LI
core  

Conditioning Factors of Linearized Wood's Function Lactation Curve Shape Parameters, Milk Yield, Fat and Protein Content in Murciano-Granadina Primiparous Does. [PDF]

open access: yesAnimals (Basel), 2020
Delgado Bermejo JV   +5 more
europepmc   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

open access: yesMolecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira   +7 more
wiley   +1 more source

PARTICULARITIES OF PREPARING FOR A MAJOR COMPETITION IN WOMEN’S 800M RACE – CASE STUDY

open access: yesSport şi Societate, 2014
Getting (acquiring) and maintaining the athletic shape for a period that includes the most important competition of a training season are among the essential issues of modern sports training methodology.
Ursanu Grigore
doaj  

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