Results 81 to 90 of about 6,626,969 (302)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Posterior shape models [PDF]

, 2013
We present a method to compute the conditional distribution of a statistical shape model given partial data. The result is a "posterior shape model", which is again a statistical shape model of the same form as the original model.
Vetter, Thomas, Albrecht, Thomas, Gerig, Thomas, Lüthi, Marcel   +3 more
core   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Tests regarding parameters of several independent gamma populations [PDF]

Gamma distribution has been used with considerable success in reliability studies and life testing experiments. This distribution assumes various forms as its shape parameter varies which makes it suitable for analyzing a variety of lifetime data.
Ram Tripathi
core  

Optimal variable shape parameters using genetic algorithm for radial basis function approximation

Ain Shams Engineering Journal, 2015
Many radial basis function (RBF) methods contain free shape parameter or parameters that play an important role for the accuracy of the method. In most papers the authors end up choosing free shape parameter by trial and error or some other ad-hoc means.
F. Afiatdoust, M. Esmaeilbeigi
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

A Shape Optimization Method Based on Sensitivity-Driven Surrogate Model for a Rim-Driven-Propelled UUV

Journal of Marine Science and Engineering
Under hull–propulsor coupling conditions, the geometric shape of an unmanned underwater vehicle (UUV) can significantly affect the inflow conditions of the aft rim-driven thruster (RDT) and, consequently, its propulsive performance.
Zhenwei Liu, Daiyu Zhang, Ning Wang, Chaoming Bao, Qian Liu, Hongwei Chen   +5 more
doaj   +1 more source

Shape parameters of a floating bubble

Physics of Fluids, 2018
For a floating bubble, in the range of Bond numbers based on an equivalent spherical radius, 0 < Boe < 1, we present analytical expressions for various shape parameters of the bubble as functions of Boe. Expressions are obtained for the radius of the rim Rr, the radius of the thin film cap Rc, the height of the top of the cap from the rim
Baburaj A. Puthenveettil, Akash Saha, Sangeeth Krishnan, E. J. Hopfinger   +3 more
openaire   +2 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source