Results 41 to 50 of about 14,812 (194)
Advanced Science, EarlyView.CircZNF148 stabilizes HK1 through deubiquitinase recruitment, thereby enhancing glycolysis and lactate production. Elevated lactate promotes PD‑L1 lactylation and membrane accumulation while suppressing CD8+ T‐cell cytotoxicity, collectively facilitating immune evasion and malignant progression in TNBC.
Yuhan Jin +17 more
wiley +1 more source
Veterinary Sciences, 2018 Shiga toxin-producing Escherichia coli, like E. coli O157:H7, are important human and animal pathogens. Naturally-acquired E. coli O157:H7 infections occur in numerous species but, particularly, cattle have been identified as a significant reservoir for ...
Elizabeth M. Antaki-Zukoski +5 more
doaj +1 more source
Advanced Science, EarlyView.Under normal conditions, MACF1 interacts with Rab14 and facilitates KIF16B‐mediated FGFR vesicle trafficking along microtubules to the plasma membrane, thereby supporting BMSC differentiation. In contrast, chronic GC exposure suppresses MACF1 expression, disrupting this transport and causing intracellular FGFR retention, which blunts osteogenic ...
Peihong Su +14 more
wiley +1 more source
Retrograde transport pathways utilised by viruses and protein toxins
Virology Journal, 2006 A model has been presented for retrograde transport of certain toxins and viruses from the cell surface to the ER that suggests an obligatory interaction with a glycolipid receptor at the cell surface. Here we review studies on the ER trafficking cholera
Roberts Lynne M +4 more
doaj +1 more source
Design of targeted B cell killing agents. [PDF]
PLoS ONE, 2011 B cells play an important role in the pathogenesis of both systemic and organ-specific autoimmune diseases. Autoreactive B cells not only produce autoantibodies, but also are capable to efficiently present specific autoantigens to T cells. Furthermore, B
Alexey V Stepanov +14 more
doaj +1 more source
Regulation of the Shiga-like toxin II operon in Escherichia coli [PDF]
Infection and Immunity, 1996 Investigations of the regulation of the bacteriophage-encoded Shiga-like toxin II (SLT-II) in Escherichia coli demonstrated that bacteriophages exhibit a regulatory impact on toxin production by two mechanisms. Firstly, replication of the toxin-converting bacteriophages brings about an increase in toxin production due to concomitant multiplication of ...
I, Mühldorfer +8 more
openaire +2 more sources
Charged and hydrophobic surfaces on the a chain of shiga-like toxin 1 recognize the C-terminal domain of ribosomal stalk proteins. [PDF]
PLoS ONE, 2012 Shiga-like toxins are ribosome-inactivating proteins (RIP) produced by pathogenic E. coli strains that are responsible for hemorrhagic colitis and hemolytic uremic syndrome.
Andrew J McCluskey +5 more
doaj +1 more source
Universitas Scientiarum, 2022 Shiga toxin producing Escherichia coli (STEC) is a bacterial pathogen that causes diarrhea and severe human diseases like HUS; its main virulence factor are the Shiga toxins (Stx1 and Stx2). Some Stx2 subtypes have been identified and associated with the
Brayan Stiven Arango +3 more
doaj +1 more source
Expression and purification of Shiga-like toxin II B subunits [PDF]
Infection and Immunity, 1995 Shiga-like toxins (SLTs), which are produced by certain strains of Escherichia coli, are composed of enzymatically active A and B subunit multimers responsible for the toxin's binding. We have previously purified large amounts of the SLT-I B subunit by using a hyperexpression vector in Vibrio cholerae under the control of the trc promoter.
D W, Acheson +6 more
openaire +2 more sources
Detection of Shiga-like toxin producing Escherichia coli from raw milk cheeses produced in Wallonia [Belgium]. [PDF]
Biotechnologie, Agronomie, Société et Environnement, 1999 Shiga-like toxin Escherichia coli (STEC) implicated in aqueous diarrhoea, haemorrhagic colitis and haemolytic uraemic syndrome, has become a serious health problem in various countries. In Belgium, all cases are sporadic and no outbreak has been detected
El-Lioui M. +4 more
doaj