Results 21 to 30 of about 14,812 (194)

Baicalin Protects Mice from Lethal Infection by Enterohemorrhagic Escherichia coli

Frontiers in Microbiology, 2017
Shiga-like toxin-producing Escherichia coli (STEC) O157:H7 poses grave challenges to public health by its ability to cause severe colonic diseases and renal failure in both human and animals.
Yong Zhang, Yong Zhang, Zhimin Qi, Zhimin Qi, Yan Liu, Yan Liu, Wenqi He, Cheng Yang, Quan Wang, Jing Dong, Xuming Deng, Xuming Deng   +11 more
doaj   +1 more source

Comparison of the glycolipid receptor specificities of Shiga-like toxin type II and Shiga-like toxin type II variants [PDF]

Infection and Immunity, 1990
The antigenically distinct Shiga-like toxins (SLTs) SLT-1 and SLT-II are cytotoxic for both Vero and HeLa cells and use Gal alpha 1-4Gal beta 1-4Glc beta 1-1Cer (Gb3) molecules as functional receptors. SLT-II-related variants SLT-IIvp and SLT-IIvh, produced by a porcine isolate and a human isolate, respectively, are cytotoxic for Vero but not HeLa ...
J E, Samuel, L P, Perera, S, Ward, A D, O'Brien, V, Ginsburg, H C, Krivan   +5 more
openaire   +2 more sources

Prevention of Shiga toxin 1-caused colon injury by plant-derived recombinant IgA

Scientific Reports, 2022
Immunoglobulin A (IgA) is a candidate antibody for oral passive immunization against mucosal pathogens like Shiga toxin-producing Escherichia coli (STEC).
Katsuhiro Nakanishi, Taichi Takase, Yuya Ohira, Ryota Ida, Noriko Mogi, Yuki Kikuchi, Minami Matsuda, Kohta Kurohane, Yoshihiro Akimoto, Junri Hayakawa, Hayato Kawakami, Yasuo Niwa, Hirokazu Kobayashi, Eiji Umemoto, Yasuyuki Imai   +14 more
doaj   +1 more source

Transcription of the Shiga-like toxin type II and Shiga-like toxin type II variant operons of Escherichia coli [PDF]

Journal of Bacteriology, 1990
Shiga-like toxin type II (SLT-II) and Shiga-like toxin type II variant (SLT-IIv) are cytotoxins produced by certain strains of Escherichia coli. Nucleotide sequence analyses had revealed that the structural genes for the A subunit and B subunit of SLT-II or SLT-IIv are arranged in an operon.
L M, Sung, M P, Jackson, A D, O'Brien, R K, Holmes   +3 more
openaire   +2 more sources

Epithelial cell signaling responses to enterohemorrhagic Escherichia coli infection

Memorias do Instituto Oswaldo Cruz, 2005
Enterohemorrhagic Escherichia coli, including the serotype O157:H7 that is most commonly identified with human disease, cause both sporadic cases and outbreaks of non-bloody diarrhea and hemorrhagic colitis.
Peter JM Ceponis, Jason D Riff, Philip M Sherman   +2 more
doaj   +1 more source

Functional capacity of Shiga-toxin promoter sequences in eukaryotic cells. [PDF]

PLoS ONE, 2013
Shiga toxins (Stx) are the main virulence factors in enterohemorrhagic Escherichia coli (EHEC) infections, causing diarrhea and hemolytic uremic syndrome (HUS). The genes encoding for Shiga toxin-2 (Stx2) are located in a bacteriophage.
Leticia V Bentancor, Marcos F Bilen, María P Mejías, Romina J Fernández-Brando, Cecilia A Panek, Maria V Ramos, Gabriela C Fernández, Martín Isturiz, Pablo D Ghiringhelli, Marina S Palermo   +9 more
doaj   +1 more source

Perspectives on Shiga-like Toxin Infections in Argentina

Journal of Food Protection, 1997
Argentina has the highest frequency of hemolytic uremic syndrome (HUS) in the world (300 cases/year). The risk of HUS in children from 6 to 48 months old is approximately 22/100,000 in Buenos Aires. In Argentina, HUS is the most frequent cause of acute renal damage and the second cause of chronic renal injury in children.
Eduardo L, López, María M, Contrini, Marcelo, Sanz, María Rosa, Viñas, Alberto, Parma, María F, DE Rosa, Thomas G, Cleary   +6 more
openaire   +2 more sources

The Effects of Shiga Toxin 1, 2 and Their Subunits on Cytokine and Chemokine Expression by Human Macrophage-Like THP-1 Cells

Toxins, 2015
Infection by Shiga toxin (Stx)-producing enterohemorrhagic Escherichia coli (EHEC) results in severe diarrhea, hemorrhagic colitis, and, occasionally, hemolytic-uremic syndrome (HUS).
Jeremy R. Brandelli, Thomas P. Griener, Austin Laing, George Mulvey, Glen D. Armstrong   +4 more
doaj   +1 more source

Production of Shiga-Like Toxin by Escherichia coli

Journal of Infectious Diseases, 1986
Escherichia coli is one of several agents that cause intestinal disease in humans and animals. Four classes of E. coli have been recognized [1], Enterotoxigenic E. coli (ETEC) strains produce a heat-labile (LT) enterotoxin and/or a heat-stable (ST) enterotoxin. Enteroinvasive E.
Marques, Lilian R. M., Moore, Marjorie A., Wells, Joy G., Wachsmuth, I. Kate, O'Brien, Alison D.   +4 more
openaire   +3 more sources

Unraveling A4GALT Mechanism and Its Modulation With Adamantyl‐Galactosylceramide Analogues: Advancing Fabry Disease Therapeutic Strategies

Angewandte Chemie, EarlyView.
A 310‐helix‐mediated conformational switch promotes a front‐face SNi‐like catalysis by human A4GALT. Mechanism‐guided design identifies AdaGalCer as a selective modulator of globotriaosylceramide (Gb3) biosynthesis, opening a clear route toward new Fabry disease therapeutics.
Nicky de Koster, Òscar Vidal‐Gironès, Rowan de Graaf, Ken Kok, Lindsey T. Lelieveld, Jackelien Hoogervorst, Maria J. Ferraz, José Pablo Rivas‐Fernández, Rob F. Lammers, Herman S. Overkleeft, Johannes M. F. G. Aerts, Rolf G. Boot, Carme Rovira, Marta Artola   +13 more
wiley   +2 more sources