Results 11 to 20 of about 29,812 (232)
Eeyarestatin 1 interferes with both retrograde and anterograde intracellular trafficking pathways. [PDF]
PLoS ONE, 2011 The small molecule Eeyarestatin I (ESI) inhibits the endoplasmic reticulum (ER)-cytosol dislocation and subsequent degradation of ERAD (ER associated protein degradation) substrates. Toxins such as ricin and Shiga/Shiga-like toxins (SLTx) are endocytosed
Mina-Olga Aletrari +10 more
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Retrograde transport pathways utilised by viruses and protein toxins [PDF]
Virology Journal, 2006 A model has been presented for retrograde transport of certain toxins and viruses from the cell surface to the ER that suggests an obligatory interaction with a glycolipid receptor at the cell surface. Here we review studies on the ER trafficking cholera
Roberts Lynne M +4 more
doaj +3 more sources
The biological properties of Shiga-like toxin I [PDF]
Shiga toxin and the Escherichia coli Shiga-like toxins (SLTs) are type 2 ribosome inactivating proteins (RIPs), exhibiting a specific RNA N-glycosidase activity comparable to that of the plant toxin ricin (Endo et al. 1988). Not only do they possess the same enzymatic activity as a plant toxin, but on examination at the molecular level, they may be ...
Burgess, Beverley Jane
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Development and evaluation of enzyme-linked immunosorbent assays for detection of shiga-like toxin I and shiga-like toxin II [PDF]
Journal of Clinical Microbiology, 1989 Shiga-like toxin (SLT)-producing Escherichia coli has been associated with a spectrum of human illnesses, including hemorrhagic colitis and hemolytic uremic syndrome. It produces at least two antigenically distinct toxins designated SLT-I and SLT-II, which have been implicated in disease.
F P, Downes +5 more
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Scientific Reports, 2021 Enterohaemorrhagic Escherichia coli (EHEC) comprise a group of intestinal pathogens responsible for a range of illnesses, including kidney failure and neurological compromise.
Patricia B. Lodato
doaj +1 more source
Sudan Journal of Medical Sciences, 2022 Background: Escherichia coli O157:H7 infection causes hemorrhagic colitis and is diagnosed based on symptoms such as cramps, stomach pain, and watery diarrhea.
Muhammad Musthafa Poyil +3 more
doaj +1 more source
Journal of Pure and Applied Microbiology, 2022 Raw milk is a nutrient-rich food that is considered a high-quality nutritional medium for many microorganism, including Escherichia coli. The aim of the present work was the diagnosis, by molecular methods, of Shiga toxins produced by E.
Balqees Yahya Najm +2 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2012 Shiga toxin producing Escherichia coli (STEC) are a major cause of food-borne illness worldwide. However, a consensus regarding the role Shiga toxins play in the onset of diarrhea and hemorrhagic colitis is lacking.
Samuel eStone +10 more
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Canada Communicable Disease Report, 2021 Background: In 2018, a Shiga toxin–producing Escherichia coli O121 outbreak that affected seven individuals was associated with raw milk Gouda-like cheese produced in British Columbia, Canada. Objectives: To describe the E.
Eva Boyd +10 more
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Comparison of the glycolipid receptor specificities of Shiga-like toxin type II and Shiga-like toxin type II variants [PDF]
Infection and Immunity, 1990 The antigenically distinct Shiga-like toxins (SLTs) SLT-1 and SLT-II are cytotoxic for both Vero and HeLa cells and use Gal alpha 1-4Gal beta 1-4Glc beta 1-1Cer (Gb3) molecules as functional receptors. SLT-II-related variants SLT-IIvp and SLT-IIvh, produced by a porcine isolate and a human isolate, respectively, are cytotoxic for Vero but not HeLa ...
J E, Samuel +5 more
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