Results 11 to 20 of about 14,812 (194)

Shiga and Shiga-like toxins [PDF]

Microbiological Reviews, 1987
Introduction . 206 Shiga Toxin in Shigella Spp. . 207 History . 207 Purification and Structure . 207 Mode of Action . 208 Receptor binding and internalization . 208 Inhibition of protein synthesis . 209 Immunology and Immunochemistry . 209 Genetics . 210 Role of Toxin in Disease . 210 Dysentery . 210 Diarrhea .210 HUS . 211 Shiga-like toxins in E. Coli
O'Brien, Alison D., Holmes, Randall K.
openaire   +2 more sources

Baicalin inhibits the lethality of Shiga-like toxin 2 in mice. [PDF]

Antimicrob Agents Chemother, 2015
ABSTRACT Shiga-like toxins (Stxs), produced by pathogenic Escherichia coli , are a major virulence factor involved in severe diseases in human and animals. These toxins are ribosome-inactivating proteins, and treatment for diseases caused by them is not available.
Dong J, Zhang Y, Chen Y, Niu X, Zhang Y, Yang C, Wang Q, Li X, Deng X.   +8 more
europepmc   +4 more sources

The pathogenic mechanisms of Shiga toxin and the Shiga‐like toxins [PDF]

Molecular Microbiology, 1991
SummaryIt is now well documented that some enteric bacteria which cause diarrhoeal and/or dysenteric disease produce, at high levels, one or more of a family of protein toxins referred to as Shiga toxin and Shiga‐like toxins (SLTs; alternatively called verocytotoxins or VTs).
V L, Tesh, A D, O'Brien
openaire   +2 more sources

Hybridization of Escherichia coli producing Shiga-like toxin I, Shiga-like toxin II, and a variant of Shiga-like toxin II with synthetic oligonucleotide probes [PDF]

Infection and Immunity, 1989
Synthetic oligonucleotides, constructed from the nucleotide sequences of genes coding for the A subunit of Shiga-like toxin (SLT) I and the B subunit of SLT-II, were used as probes at different degrees of stringency to identify Escherichia coli producing different types of SLTs. At 45 degrees C, the A-I oligonucleotide probe hybridized with E.
J E, Brown, O, Sethabutr, M P, Jackson, S, Lolekha, P, Echeverria   +4 more
openaire   +2 more sources

Development and evaluation of enzyme-linked immunosorbent assays for detection of shiga-like toxin I and shiga-like toxin II [PDF]

Journal of Clinical Microbiology, 1989
Shiga-like toxin (SLT)-producing Escherichia coli has been associated with a spectrum of human illnesses, including hemorrhagic colitis and hemolytic uremic syndrome. It produces at least two antigenically distinct toxins designated SLT-I and SLT-II, which have been implicated in disease.
F P, Downes, J H, Green, K, Greene, N, Strockbine, J G, Wells, I K, Wachsmuth   +5 more
openaire   +3 more sources

Eeyarestatin 1 interferes with both retrograde and anterograde intracellular trafficking pathways. [PDF]

PLoS ONE, 2011
The small molecule Eeyarestatin I (ESI) inhibits the endoplasmic reticulum (ER)-cytosol dislocation and subsequent degradation of ERAD (ER associated protein degradation) substrates. Toxins such as ricin and Shiga/Shiga-like toxins (SLTx) are endocytosed
Mina-Olga Aletrari, Craig McKibbin, Helen Williams, Vidya Pawar, Paola Pietroni, J Michael Lord, Sabine L Flitsch, Roger Whitehead, Eileithyia Swanton, Stephen High, Robert A Spooner   +10 more
doaj   +1 more source

Shiga toxin 2-induced intestinal pathology in infant rabbits is A-subunit dependent and responsive to the tyrosine kinase and potential ZAK inhibitor imatinib

Frontiers in Cellular and Infection Microbiology, 2012
Shiga toxin producing Escherichia coli (STEC) are a major cause of food-borne illness worldwide. However, a consensus regarding the role Shiga toxins play in the onset of diarrhea and hemorrhagic colitis is lacking.
Samuel eStone, Cheleste eThorpe, Amrita eAhluwalia, Amrita eAhluwalia, Arlin eRogers, Fumiko eObata, Aimee eVozenilek, Glynis eKolling, Anne eKane, Bruce eMagun, Dakshina eJandhyala   +10 more
doaj   +1 more source

Escherichia coli O121 outbreak associated with raw milk Gouda-like cheese in British Columbia, Canada, 2018

Canada Communicable Disease Report, 2021
Background: In 2018, a Shiga toxin–producing Escherichia coli O121 outbreak that affected seven individuals was associated with raw milk Gouda-like cheese produced in British Columbia, Canada. Objectives: To describe the E.
Eva Boyd, Aljosa Trmcic, Marsha Taylor, Sion Shyng, Paul Hasselback, Stephanie Man, Christine Tchao, Jason Stone, Loretta Janz, Linda Hoang, Eleni Galanis   +10 more
doaj   +1 more source

Fighting Fire with Fire: Phage Potential for the Treatment of E. coli O157 Infection

Antibiotics, 2018
Hemolytic⁻uremic syndrome is a life-threating disease most often associated with Shiga toxin-producing microorganisms like Escherichia coli (STEC), including E. coli O157:H7.
Cristina Howard-Varona, Dean R. Vik, Natalie E. Solonenko, Yueh-Fen Li, M. Consuelo Gazitua, Lauren Chittick, Jennifer K. Samiec, Aubrey E. Jensen, Paige Anderson, Adrian Howard-Varona, Anika A. Kinkhabwala, Stephen T. Abedon, Matthew B. Sullivan   +12 more
doaj   +1 more source

CHITOSAN INHIBITION TEST AGAINST E. coli AND DIGESTIBILITY OF THE RATION IN THE IN-VITRO METHOD

Jurnal Pendidikan Matematika dan IPA, 2020
Diarrhea and vomiting are often caused by E coli bacteria. E coli bacteria has a strain of Shigatoxigenic Escherichia coli (STEC), producing Shiga poisons or poisons such as Shiga (verotoxin) which are harmful and pollute nature.
Eli Sahara, Sofia Sandi, Fitra Yosi
doaj   +1 more source