Eeyarestatin 1 interferes with both retrograde and anterograde intracellular trafficking pathways. [PDF]
PLoS ONE, 2011 The small molecule Eeyarestatin I (ESI) inhibits the endoplasmic reticulum (ER)-cytosol dislocation and subsequent degradation of ERAD (ER associated protein degradation) substrates. Toxins such as ricin and Shiga/Shiga-like toxins (SLTx) are endocytosed
Mina-Olga Aletrari +10 more
doaj +3 more sources
Shiga and Shiga-Like Toxins [PDF]
Microbiological Reviews, 1987 Introduction ........................ 206 Shiga Toxin in Shigella Spp. ........................ 207 History ........................ 207 Purification and Structure ........................ 207 Mode of Action ........................
O\u27Brien, Alison D. +1 more
core +4 more sources
Retrograde transport pathways utilised by viruses and protein toxins [PDF]
Virology Journal, 2006 A model has been presented for retrograde transport of certain toxins and viruses from the cell surface to the ER that suggests an obligatory interaction with a glycolipid receptor at the cell surface. Here we review studies on the ER trafficking cholera
Roberts Lynne M +4 more
doaj +2 more sources
The biological properties of Shiga-like toxin I [PDF]
Shiga toxin and the Escherichia coli Shiga-like toxins (SLTs) are type 2 ribosome inactivating proteins (RIPs), exhibiting a specific RNA N-glycosidase activity comparable to that of the plant toxin ricin (Endo et al. 1988).
Burgess, Beverley Jane
core +2 more sources
Characterizing RecA-Independent Induction of Shiga toxin2-encoding Phages by EDTA Treatment [PDF]
, 2012 The bacteriophage life cycle has an important role in Shiga toxin (Stx) expression. The induction of Shiga toxin-encoding phages (Stx phages) increases toxin production as a result of replication of the phage genome, and phage lysis of the host cell also
Muniesa Maite +8 more
core +3 more sources
The pathogenic mechanisms of Shiga toxin and the Shiga‐like toxins [PDF]
Molecular Microbiology, 1991 SummaryIt is now well documented that some enteric bacteria which cause diarrhoeal and/or dysenteric disease produce, at high levels, one or more of a family of protein toxins referred to as Shiga toxin and Shiga‐like toxins (SLTs; alternatively called verocytotoxins or VTs).
V L, Tesh, A D, O'Brien
openaire +2 more sources
Baicalin inhibits the lethality of Shiga-like toxin 2 in mice. [PDF]
Antimicrob Agents Chemother, 2015 ABSTRACT Shiga-like toxins (Stxs), produced by pathogenic Escherichia coli , are a major virulence factor involved in severe diseases in human and animals. These toxins are ribosome-inactivating proteins, and treatment for diseases caused by them is not available.
Dong J +8 more
europepmc +4 more sources
Hybridization of Escherichia coli producing Shiga-like toxin I, Shiga-like toxin II, and a variant of Shiga-like toxin II with synthetic oligonucleotide probes [PDF]
Infection and Immunity, 1989 Synthetic oligonucleotides, constructed from the nucleotide sequences of genes coding for the A subunit of Shiga-like toxin (SLT) I and the B subunit of SLT-II, were used as probes at different degrees of stringency to identify Escherichia coli producing different types of SLTs. At 45 degrees C, the A-I oligonucleotide probe hybridized with E.
J E, Brown +4 more
openaire +2 more sources
Inhibition of development of Shiga toxin-converting bacteriophages by either treatment with citrate or amino acid starvation [PDF]
, 2012 Objectives: Shiga toxin–producing Escherichia coli (STEC) are pathogenic strains, whose virulence depends on induction of Shiga toxin–converting prophages and their subsequent lytic development.
Bożena Nejman-Faleńczyk +9 more
core +2 more sources
Development and evaluation of enzyme-linked immunosorbent assays for detection of shiga-like toxin I and shiga-like toxin II [PDF]
Journal of Clinical Microbiology, 1989 Shiga-like toxin (SLT)-producing Escherichia coli has been associated with a spectrum of human illnesses, including hemorrhagic colitis and hemolytic uremic syndrome. It produces at least two antigenically distinct toxins designated SLT-I and SLT-II, which have been implicated in disease.
F P, Downes +5 more
openaire +3 more sources