Results 51 to 60 of about 4,685,864 (234)

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Rapid Multiplex Antimicrobial Resistance Profiling and Bacterial Identification by LAP‐MALDI Mass Spectrometry Biotyping

Advanced Science, EarlyView.
Liquid atmospheric pressure matrix‐assisted laser desorption/ionization (LAP‐MALDI) mass spectrometry (MS) provides multiplexed biotyping of microbial cultures using a fast and simple workflow. This is demonstrated for clinically relevant bacteria, resulting in accurate antimicrobial resistance (AMR) detection, speciation by MS/MS sequencing and ...
Lily R. Adair, Shabnam Iyer, Ian M. Jones, Rainer Cramer   +3 more
wiley   +1 more source

Shiga Toxin-Producing E. coli in Animals: Detection, Characterization, and Virulence Assessment

, 2021
Cattle and other ruminants are primary reservoirs for Shiga toxin-producing Escherichia coli (STEC) strains which have a highly variable, but unpredictable, pathogenic potential for humans.
Christian Menge, Barth, Stefanie, Christian Berens, Menge, Christian, Stefanie A. Barth, Bauerfeind, Rolf, Rolf Bauerfeind, Berens, Christian   +7 more
core   +1 more source

Single‐Cell Transcriptomics and Metabolomics Reveal Glutamate Dehydrogenase as a Central Regulator of Nitrogen Metabolic Remodeling During Alkalinity Adaptation in Crustaceans

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals the cellular response of Macrobrachium hainanense to carbonate alkalinity stress. Alkalinity stress impairs branchial ammonia excretion, induces mitochondrial dysfunction, and drives cell‐type‐specific changes in gills and hemocytes.
Yiting Jin, Zhimin Lv, Chao Bian, Qibin Yang, Na Zhou, Jianguang Qin, Shengming Sun   +6 more
wiley   +1 more source

Draft Genome Sequence of an Escherichia coli O157:H43 Strain Isolated from Cattle [PDF]

, 2013
Here we report the draft genome sequence of an Escherichia coli O157:H43 strain, designated T22, with an atypical virulence gene profile and isolated from healthy cattle.
Maróti, Gergely, Szűcs, Attila, Sváb, Domonkos, Horváth, Balázs, Tóth, István   +4 more
core   +1 more source

Altered Brain Penetration of Diclofenac and Mefenamic Acid, but Not Acetaminophen, in Shiga-Like Toxin II-Treated Mice

Journal of Pharmacological Sciences, 2005
It is well accepted that bacterial and virus infections elevate the levels of cytokines in serum and cerebrospinal fluids. Such high levels of cytokines might alter the integrity of the blood-brain barrier (BBB) and/or blood-cerebrospinal fluid barrier ...
Masaya Fukuda, Kiyoyuki Kitaichi, Fumie Abe, Yohei Fujimoto, Kenji Takagi, Kenzo Takagi, Tsuneo Morishima, Takaaki Hasegawa   +7 more
doaj   +1 more source

Intestinal phages interact with bacteria and are involved in human diseases

Gut Microbes, 2022
Phages are the most abundant and diverse biological entities on Earth and exert specific effects on bacterial hosts. The coexistence of phages and bacteria in the intestinal tract is dynamic and interdependent.
Han Shuwen, Ding Kefeng
doaj   +1 more source

circZNF148 Drives Glucose Metabolism Reprogramming to Enhance Metastasis and Immune Evasion via HK1 Stabilization in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
CircZNF148 stabilizes HK1 through deubiquitinase recruitment, thereby enhancing glycolysis and lactate production. Elevated lactate promotes PD‑L1 lactylation and membrane accumulation while suppressing CD8+ T‐cell cytotoxicity, collectively facilitating immune evasion and malignant progression in TNBC.
Yuhan Jin, Wenjing Zhao, Lei Wang, Jianing Wang, Keying Zhao, Dan Luo, Yifei Wang, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Xiaoyan Li, Bing Chen, Lijuan Wang, Yiran Liang, Qifeng Yang   +17 more
wiley   +1 more source

Structural insights into Clostridium perfringens delta toxin pore formation [PDF]

, 2013
Clostridium perfringens Delta toxin is one of the three hemolysin-like proteins produced by C. perfringens type C and possibly type B strains. One of the others, NetB, has been shown to be the major cause of Avian Nectrotic Enteritis, which following the
Claire E Naylor, Gibert, M., Popoff, Michel, Popoff, M.R., Motta, A., Michel R Popoff, Christos G Savva, Jessica Huyet (425370), Ajit K. Basak (425373), Michel R. Popoff, Huyet Jessica, Naylor, Claire E., Basak Ajit K., Gibert, Maryse, Basak, Ajit,, Claire E. Naylor (425371), Ajit K. Basak, Savva Christos G., Michel R. Popoff (147963), Motta, Andrea, Claire E. Naylor, Basak, Ajit, K, Huyet, Jessica, Basak, Ajit K., Savva, Christos, G, Popoff Michel R., Naylor, Claire, E, Naylor Claire E., Ajit K Basak, Christos G. Savva (425372), Gibert Maryse, Naylor, Claire,, Savva, Christos,, Christos G. Savva, Maryse Gibert, Jessica Huyet, Maryse Gibert (269234), Savva, Christos G.   +37 more
core   +1 more source

Regulation of the Shiga-like toxin II operon in Escherichia coli [PDF]

Infection and Immunity, 1996
Investigations of the regulation of the bacteriophage-encoded Shiga-like toxin II (SLT-II) in Escherichia coli demonstrated that bacteriophages exhibit a regulatory impact on toxin production by two mechanisms. Firstly, replication of the toxin-converting bacteriophages brings about an increase in toxin production due to concomitant multiplication of ...
I, Mühldorfer, J, Hacker, G T, Keusch, D W, Acheson, H, Tschäpe, A V, Kane, A, Ritter, T, Olschläger, A, Donohue-Rolfe   +8 more
openaire   +2 more sources