Results 61 to 70 of about 29,812 (232)

ArcA positively regulates the expression of virulence genes and contributes to virulence of porcine Shiga toxin-producing enterotoxigenic Escherichia coli

Microbiology Spectrum, 2023
Enterotoxigenic Escherichia coli (ETEC) cause severe diarrhea in humans and animals. These bacteria encode two major classes of virulence factors, adhesins that promote colonization of the small intestine and enterotoxins that induce fluid secretion and ...
Fengwei Jiang, Yan Yang, Zhao Mao, Wentong Cai, Ganwu Li   +4 more
doaj   +1 more source

Lack of specific binding of Shiga-like toxin (verocytotoxin) and non-specific interaction of Shiga-like toxin 2 antibody with human polymorphonuclear leucocytes [PDF]

Nephrology Dialysis Transplantation, 2007
After gastrointestinal infection with Shiga-like toxin (Stx) producing Escherichia coli, the toxin is transported from the intestine to the renal microvascular endothelium. This is the main target for Stx in humans. Previous studies indicated that polymorphonuclear leucocytes (PMN) could serve as carriers for Stx in the systemic circulation.
Geelen, J.M., Velden, T.J.A.M. van der, Loo, D.M.W.M. te, Boerman, O.C., Heuvel, L.P.W.J. van den, Monnens, L.A.H.   +5 more
openaire   +3 more sources

Multi‐omics biomarkers for intestinal infection and inflammation in inflammatory bowel disease: Current evidence, translational challenges, and diagnostic opportunities

Interdisciplinary Medicine, EarlyView.
Prospective multi‐site cohorts, multi‐omics profiling, and computational analysis may help identify biomarker patterns across clinical settings in IBD and superimposed infections. With further mechanistic and clinical validation, these signals could support the development of practical multi‐analyte tools for more precise diagnosis and management ...
Ziyu Yang, Jiayi Yao, Xinxian Zhao, Yan Xu, Yifan Chen, Tianchi Chen, Ying Jian, Min Li   +7 more
wiley   +1 more source

A mutant Shiga-like toxin IIe bound to its receptor Gb 3 : structure of a group II Shiga-like toxin with altered binding specificity [PDF]

Structure, 2000
Shiga-like toxins (SLTs) are produced by the pathogenic strains of Escherichia coli that cause hemorrhagic colitis and hemolytic uremic syndrome. These diseases in humans are generally associated with group II family members (SLT-II and SLT-IIc), whereas SLT-IIe (pig edema toxin) is central to edema disease of swine.
Ling, Hong, Pannu, Navraj S, Boodhoo, Amechand, Armstrong, Glen D, Clark, Clifford G, Brunton, James L, Read, Randy J   +6 more
openaire   +2 more sources

Targeting the intratumoral microbiota to overcome cancer immunotherapy resistance

Interdisciplinary Medicine, EarlyView.
This review delineates the mechanisms of intratumoral microbiota in cancer immunotherapy resistance, and offers strategies for microbiota‐targeted precision immunotherapy. Abstract Cancer remains a significant global health threat. The tumor microenvironment (TME) is a sophisticated ecological niche that exerts a pivotal effect on treatment outcomes ...
Bufu Tang, Tong Jiang, Yaling Lin, Wei Zhang, Hongjie Fan, Minjie Yang, Bingzhe Li, Yaozu Liu, Changyu Li, Xuran Jin, Wen Zhang, Zhiping Yan, Qianqian Zhao, Xuefeng Kan, Xudong Qu   +14 more
wiley   +1 more source

Comparative Pathogenicity of Wildlife and Bovine Escherichia coli O157:H7 Strains in Experimentally Inoculated Neonatal Jersey Calves

Veterinary Sciences, 2018
Shiga toxin-producing Escherichia coli, like E. coli O157:H7, are important human and animal pathogens. Naturally-acquired E. coli O157:H7 infections occur in numerous species but, particularly, cattle have been identified as a significant reservoir for ...
Elizabeth M. Antaki-Zukoski, Xunde Li, Patricia A. Pesavento, Tran H. B. Nguyen, Bruce R. Hoar, Edward R. Atwill   +5 more
doaj   +1 more source

Design of targeted B cell killing agents. [PDF]

PLoS ONE, 2011
B cells play an important role in the pathogenesis of both systemic and organ-specific autoimmune diseases. Autoreactive B cells not only produce autoantibodies, but also are capable to efficiently present specific autoantigens to T cells. Furthermore, B
Alexey V Stepanov, Alexey A Belogurov, Natalia A Ponomarenko, Oleg A Stremovskiy, Leonid V Kozlov, Anna M Bichucher, Sergey E Dmitriev, Ivan V Smirnov, Olga G Shamborant, Dmitry S Balabashin, Lidia P Sashchenko, Alexander G Tonevitsky, Alain Friboulet, Alexander G Gabibov, Sergey M Deyev   +14 more
doaj   +1 more source

A method for detecting Shiga toxin and Shiga-like toxin-l in pure and mixed culture [PDF]

Journal of Medical Microbiology, 1990
Shiga toxin and Shiga-like toxins (SLTs, syn. Verotoxins) are currently detected by tissue culture assays that are expensive, time-consuming and require specialised facilities and experienced personnel. We have developed a rapid method to detect Shiga toxin and SLT-I (Verotoxin 1) based on their binding to globotriosyl ceramide (Gb3).
S, Ashkenazi, T G, Cleary
openaire   +2 more sources

Colonic Barrier Dysfunction and Inflammation Induced by Nano‐/Micro‐Plastics Fibers in Mice via the FAK/NF‐κB/iNOS and TLR4/NF‐κB/iNOS Pathways

Journal of Applied Toxicology, EarlyView.
ABSTRACT As emerging environmental contaminants, nano‐ and micro‐plastics (NMPs) have drawn increasing research attention due to potential hazards to organisms. Particle shape is a key factor influencing the toxic effects of NMPs, and NMPs of different shapes cause varying degrees of tissue damage. We investigated the specific mechanisms of polystyrene
Yuting Li, Shibo Bao, Puyang Huang, Jiahui Wang, Hongfeng Li, Yahong Liu, Kai Wang, Jianjun Du, Lingjun Yan, Guowei Pan, Wei Sun   +10 more
wiley   +1 more source

454-Pyrosequencing: A Molecular Battiscope for Freshwater Viral Ecology [PDF]

, 2010
Viruses, the most abundant biological entities on the planet, are capable of infecting organisms from all three branches of life, although the majority infect bacteria where the greatest degree of cellular diversity lies.
Allison, Heather E, Woodward, Martin J, Rooks, David, Rooks, D. J., Smith, Darren L, McCarthy, Alan J, McDonald, James E; id_orcid, Woodward, Martin J., Darren L. Smith, Smith, Darren, Rooks, David J, David J. Rooks, Martin J. Woodward, McCarthy, Alan, McCarthy, A. J., Smith, D. L., Heather E. Allison, McDonald, James, Allison, Heather, James E. McDonald, Woodward, Martin, Alan J. McCarthy, McDonald, J. E., Allison, H. E.   +23 more
core   +1 more source