Results 11 to 20 of about 366,512 (248)

Shiga Toxin/Lipopolysaccharide Activates Caspase-4 and Gasdermin D to Trigger Mitochondrial Reactive Oxygen Species Upstream of the NLRP3 Inflammasome

Cell Reports, 2018
Summary: The non-canonical caspase-4 and canonical NLRP3 inflammasomes are both activated by intracellular lipopolysaccharide (LPS), but the crosstalk between these two pathways remains unclear.
Jaye M. Platnich, Hyunjae Chung, Arthur Lau, Christina F. Sandall, Adom Bondzi-Simpson, Huey-Miin Chen, Takanori Komada, Aaron C. Trotman-Grant, Jeremy R. Brandelli, Justin Chun, Paul L. Beck, Dana J. Philpott, Stephen E. Girardin, May Ho, Roger P. Johnson, Justin A. MacDonald, Glen D. Armstrong, Daniel A. Muruve   +17 more
doaj   +4 more sources

The Effect of Mitomycin C on Induction of Shiga Toxin Production in Clinical STEC Isolates [PDF]

Toxins
Early determination of the Shiga toxin type of Shiga toxin-producing Escherichia coli (STEC) is crucial for guiding STEC-infected patients for proper and timely treatment and patient care.
Surangi H. Thilakarathna, Brendon Parsons, Linda Chui   +2 more
doaj   +2 more sources

Treatment Strategies for Infections With Shiga Toxin-Producing Escherichia coli

Frontiers in Cellular and Infection Microbiology, 2020
Infections with Shiga toxin-producing Escherichia coli (STEC) cause outbreaks of severe diarrheal disease in children and the elderly around the world. The severe complications associated with toxin production and release range from bloody diarrhea and ...
Sabrina Mühlen, Sabrina Mühlen, Petra Dersch, Petra Dersch   +3 more
doaj   +2 more sources

A Comprehensive Review on Shiga Toxin Subtypes and Their Niche-Related Distribution Characteristics in Shiga-Toxin-Producing E. coli and Other Bacterial Hosts

Microorganisms
Shiga toxin (Stx), the main virulence factor of Shiga-toxin-producing E. coli (STEC), was first discovered in Shigella dysenteriae strains. While several other bacterial species have since been reported to produce Stx, STEC poses the most significant ...
Xuan Wang, Daniel Yu, Linda Chui, Tiantian Zhou, Yu Feng, Yuhao Cao, Shuai Zhi   +6 more
doaj   +2 more sources

Microvesicle Involvement in Shiga Toxin-Associated Infection

Toxins, 2017
Shiga toxin is the main virulence factor of enterohemorrhagic Escherichia coli, a non-invasive pathogen that releases virulence factors in the intestine, causing hemorrhagic colitis and, in severe cases, hemolytic uremic syndrome (HUS).
Annie Villysson, Ashmita Tontanahal, Diana Karpman   +2 more
doaj   +2 more sources

Shiga Toxin—A Model for Glycolipid-Dependent and Lectin-Driven Endocytosis

Toxins, 2017
The cellular entry of the bacterial Shiga toxin and the related verotoxins has been scrutinized in quite some detail. This is due to their importance as a threat to human health.
Ludger Johannes
doaj   +2 more sources

Development of Recombinant Lactococcus lactis Displaying Albumin-Binding Domain Variants against Shiga Toxin 1 B Subunit. [PDF]

PLoS ONE, 2016
Infections with shiga toxin-producing bacteria, like enterohemorrhagic Escherichia coli and Shigella dysenteriae, represent a serious medical problem. No specific and effective treatment is available for patients with these infections, creating a need ...
Petra Zadravec, Lucie Marečková, Hana Petroková, Vesna Hodnik, Milica Perišić Nanut, Gregor Anderluh, Borut Štrukelj, Petr Malý, Aleš Berlec   +8 more
doaj   +2 more sources

Shiga Toxin [PDF]

Definitions, 2020
N. Moore
openaire   +2 more sources

Isothermal Amplification and Lateral Flow Nucleic Acid Test for the Detection of Shiga Toxin-Producing Bacteria for Food Monitoring

Chemosensors, 2022
Foodborne bacteria have persisted as a significant threat to public health and to the food and agriculture industry. Due to the widespread impact of these pathogens, there has been a push for the development of strategies that can rapidly detect ...
Sabrina Petrucci, Emre Dikici, Sylvia Daunert, Sapna K. Deo   +3 more
doaj   +1 more source

Diagnosis and Treatment for Shiga Toxin-Producing Escherichia coli Associated Hemolytic Uremic Syndrome

Toxins, 2022
Shiga toxin-producing Escherichia coli (STEC)-associated hemolytic uremic syndrome (STEC-HUS) is a clinical syndrome involving hemolytic anemia (with fragmented red blood cells), low levels of platelets in the blood (thrombocytopenia), and acute kidney ...
Yang Liu, H. Thaker, Chunyan Wang, Zhonggao Xu, M. Dong   +4 more
semanticscholar   +1 more source