Results 231 to 240 of about 130,169 (275)

Differential cytotoxic actions of Shiga toxin 1 and Shiga toxin 2 on microvascular and macrovascular endothelial cells

Thrombosis and Haemostasis, 2010
SummaryShiga toxin (Stx)-mediated injury to vascular endothelial cells in the kidneys, brain and other organs underlies the pathogenesis of haemolytic uraemic syndrome (HUS) caused by enterohaemorrhagic Escherichia coli (EHEC). We present a direct and comprehensive comparison of cellular injury induced by the two major Stx types, Stx1 and Stx2, in ...
Andreas Bauwens, M. Bielaszewska, B. Kemper, P. Langehanenberg, G. Bally, R. Reichelt, D. Mulac, H. Humpf, A. Friedrich, K. Kim, H. Karch, J. Müthing   +11 more
semanticscholar   +3 more sources

Shiga toxin 1: damage to DNA in vitro

Toxicon, 2001
Shiga toxins share with plant ribosome-inactivating proteins the same enzymatic mechanism of action: the removal of a specific adenine from 28S RNA when acting on ribosomes and the removal of multiple adenines when acting on DNA in vitro. The activity on DNA, only recently reported, is particularly evident, and has been studied mostly at acidic pH. For
M, Brigotti, P, Accorsi, D, Carnicelli, S, Rizzi, A, González Vara, L, Montanaro, S, Sperti   +6 more
openaire   +2 more sources

Enhanced production of Shiga toxin 1 in enterohaemorrhagic Escherichia coli by oxygen

Microbiology, 2021
Enterohaemorrhagic Escherichia coli (EHEC) produces Shiga toxin 1 (Stx1) and Shiga toxin 2 (Stx2). Although stx1 and stx2 were found within the late operons of the Stx-encoding phages (Stx-phages), stx1 could mainly be transcribed from the stx1 promoter (P
Takeshi Shimizu, Manami Onuki, Shin Suzuki, Shinichiro Hirai, Eiji Yokoyama, Akio Matsumoto, Takashi Hamabata   +6 more
openaire   +2 more sources

Immunolabelling of shiga toxin in macrophages infected with Shigella dysenteriae 1

Research in Microbiology, 1990
Immunolabelling of Shiga toxin in macrophages infected with a non-invasive Shigella dysenteriae 1 isolate showed that bacteria remained alive for 3 h after ingestion within the phagocytic vacuole and synthesized Shiga toxin. The normal process of toxin secretion was, however, impaired by the phagosomal environment and toxin molecules accumulated within
B, Dacosta, P, Sansonetti, A, Ryter
openaire   +2 more sources

Genomic Insight into Natural Inactivation of Shiga Toxin 2 Production in an Environmental Escherichia coli Strain Producing Shiga Toxin 1

Foodborne Pathogens and Disease, 2020
Shiga toxin-producing Escherichia coli (STEC) consists of a group of diverse strains differing greatly in genetic make-up and pathogenicity potential. Here, we investigated production of Shiga toxins (Stxs) in a bovine isolate carrying multiple Shiga toxin genes (stxs) after exposure to several antibiotics commonly used in food animals.
Michelle Qiu, Carter, Antares, Pham, Xiaohua, He, Robert, Hnasko   +3 more
openaire   +2 more sources

Human Platelet Aggregation Is Not Altered by Shiga Toxins 1 or 2

Thrombosis Research, 2000
The hemolytic uremic syndrome involves the presence of Shiga toxin producing strains of Escherichia coli and is associated with thrombocytopenia, platelet activation, and microthrombi formation. We have, therefore, investigated the ability of Shiga toxin isotypes 1 and 2 to cause or enhance platelet aggregation under resting or arterial-flow conditions
D, Viisoreanu, R, Polanowska-Grabowska, S, Suttitanamongkol, T G, Obrig, A R, Gear   +4 more
openaire   +2 more sources

The use of Shiga-like toxin 1 in cancer therapy

Critical Reviews in Oncology/Hematology, 2001
The ribosome-inactivating protein, Shiga-like toxin-1 (SLT-1, SLT-I, Verotoxin 1, VT1) targets cells that express the glycolipid globotriaosylceramide (CD77) on their surface. The frequent occurrence of SLT-1 receptors on tumor cells derived from patients with hematological cancers (follicular lymphoma, multiple myeloma, chronic lymphocytic leukemia ...
openaire   +2 more sources

A nasal vaccine comprising B-subunit derivative of Shiga toxin 2 for cross-protection against Shiga toxin types 1 and 2

Vaccine, 2008
Enterohemorrhagic Escherichia coli (EHEC) produces Stx1 and Stx2 causing severe diseases. Their B-subunits (StxBs) exhibit low immunogenicity and the anti-StxB antibodies neutralizing both Stxs has not been prepared yet. By intranasal vaccination with His-tagged-StxB (Stx1B-His or Stx2B-His) plus a mutant heat-labile enterotoxin (mLT) in mice, their ...
Takao, Tsuji, Takeshi, Shimizu, Keiko, Sasaki, Kentaro, Tsukamoto, Hideyuki, Arimitsu, Sadayuki, Ochi, Toshiyasu, Shimizu, Koki, Taniguchi, Masatoshi, Noda, Paola, Neri, Hiroshi, Mori   +10 more
openaire   +2 more sources

The Design, Synthesis and Evaluation of Multivalent Heterobifunctional Ligands Specific for Shiga Toxin 1 and Shiga Toxin 2

2014
Hemolytic uremic syndrome (HUS) is a potential life-threatening condition caused by infection with Shiga toxin-producing Escherichia coli O157:H7. There are two major types of Shiga toxins, namely, Shiga toxin 1 (Stx1) and Shiga toxin 2 (Stx2), of which, Stx2 is clinically most closely associated with enterohemorrhagic E. coli O157:H7-mediated HUS. The
openaire   +1 more source

Differential sensitivity of viruses to the antiviral activity of Shiga toxin 1 A subunit

Virus Research, 2007
The non-toxic enzymic A subunit of Shiga toxin 1 (StxA1) reduces expression and replication of the bovine retroviruses, bovine leukemia virus and bovine immunodeficiency virus (BIV). Here, the impact of StxA1 on representative positive and negative stranded RNA viruses was compared.
Witold A, Ferens, Mandi, Halver, Kurt E, Gustin, Troy, Ott, Carolyn J, Hovde   +4 more
openaire   +2 more sources