Results 101 to 110 of about 22,441 (226)

Genetic variation in the flanking regions of Shiga toxin 2 gene in Shiga toxin-producingEscherichia coliO157:H7 isolated in Japan [PDF]

FEMS Microbiology Letters, 2002
We found frequent IS1 integration nearby the stx(2) gene during in vitro mutagenesis of an stx(2) variant, stx(2vhd). To examine the possibility that such insertions have been contributing to generate new stx(2) variants, we screened 86 strains of Escherichia coli O157:H7 isolated in Japan for variations in the ca. 4-kb region flanking the stx(2) locus
Takashi, Hamabata, Tetsuya, Tanaka, Ayako, Ozawa, Tatsuichiro, Shima, Toshio, Sato, Yoshifumi, Takeda   +5 more
openaire   +2 more sources

Efficacy of Adjuvant Interferon‐β Versus Observation for Resected Nail Apparatus Melanoma: A Multicenter Retrospective Study

The Journal of Dermatology, EarlyView.
ABSTRACT Nail apparatus melanoma (NAM) is a biologically and clinically distinct subtype of melanoma; however, the efficacy of adjuvant interferon (IFN) therapy in this population remains unclear. We conducted a multicenter retrospective study to compare adjuvant IFN‐β (adj‐IFN) with observation (OBS) in patients with resected stage IIB, IIC, or III ...
Takaya Komori, Eiji Nakano, Yukiko Kiniwa, Shoichiro Mori, Sotaro Yamamoto, Hiroshi Kato, Shusuke Yoshikawa, Koji Yoshino, Megumi Aoki, Tatsuya Takenouchi, Takuya Maeda, Keijun Yoshino, Shuichi Ohe, Kenta Nakama, Hideyuki Ishikawa, Yoshiyuki Nakamura, Toshihiro Takai, Takamichi Ito, Hiroshi Kitagawa, Hiraku Kokubu, Naohito Hatta, Takeru Funakoshi, Toshihiko Hoashi, Takayuki Suyama, Susumu Fujiwara, Mamiko Masuzawa, Hiroshi Uchi, Takuya Miyagawa, Soichiro Kado, Yuki Yamamoto, Jun Asai, Junji Kato, Taku Maeda, Natsuki Baba, Yukihiko Kato, Kohei Oashi, Takeo Maekawa, Shunichi Jinnai, Aya Nishizawa, Ko Kagoyama, Atsushi Otsuka, Katsuhiko Nishihara, Dai Ogata, Kenjiro Namikawa, Yasuhiro Nakamura, Shigeto Matsushita   +45 more
wiley   +1 more source

Baicalin Protects Mice from Lethal Infection by Enterohemorrhagic Escherichia coli

Frontiers in Microbiology, 2017
Shiga-like toxin-producing Escherichia coli (STEC) O157:H7 poses grave challenges to public health by its ability to cause severe colonic diseases and renal failure in both human and animals.
Yong Zhang, Yong Zhang, Zhimin Qi, Zhimin Qi, Yan Liu, Yan Liu, Wenqi He, Cheng Yang, Quan Wang, Jing Dong, Xuming Deng, Xuming Deng   +11 more
doaj   +1 more source

Lack of specific binding of Shiga-like toxin (verocytotoxin) and non-specific interaction of Shiga-like toxin 2 antibody with human polymorphonuclear leucocytes [PDF]

Nephrology Dialysis Transplantation, 2007
After gastrointestinal infection with Shiga-like toxin (Stx) producing Escherichia coli, the toxin is transported from the intestine to the renal microvascular endothelium. This is the main target for Stx in humans. Previous studies indicated that polymorphonuclear leucocytes (PMN) could serve as carriers for Stx in the systemic circulation.
Geelen, J.M., Velden, T.J.A.M. van der, Loo, D.M.W.M. te, Boerman, O.C., Heuvel, L.P.W.J. van den, Monnens, L.A.H.   +5 more
openaire   +3 more sources

Prevalence and Genomic Characterization of mcr‐Positive Enterobacteriaceae in Retail Meat in Thailand Following the Colistin Ban

Microbiology and Immunology, EarlyView.
ABSTRACT This study aimed to investigate the prevalence and characteristics of mcr‐positive Enterobacteriaceae in retail meat in Thailand following the national ban on prophylactic colistin use in food producing animals. A total of 152 meat samples (103 chicken and 49 pork) were collected from supermarkets and open markets between July and September ...
Ahmed Abououf, Sharda Prasad Awasthi, Asmaa M. Elbastawesy, Noritoshi Hatanaka, Atsushi Hinenoya, Srinuan Somroop, Yukihiro Kaneko, Shinji Yamasaki   +7 more
wiley   +1 more source

Anti-tumor activity of Escherichia coli Shiga toxin A subunit delivered by SF9 insect cells

Journal of Pharmacological Sciences, 2018
Cancer remains a major health problem around the world. A Shiga toxin is a bacterial toxin often produced by Shigella dysenteriae and Escherichia coli. A subunit of the Shiga toxin (StxA) is a cytotoxic agent which could be used to induce death in cancer
Mana Oloomi, Maryam Imani, Ramezan Behzadi, Mohsen Asori, Saeid Bouzari, Bita Mokhlesi   +5 more
doaj   +1 more source

Advances in pathogenesis and therapy of hemolytic uremic syndrome caused by shiga toxin‐2 [PDF]

IUBMB Life, 2013
AbstractShiga toxin (Stx) producing Escherichia coli (STEC) is responsible to bloody diarrhea (hemorrhagic colitis) and the hemolytic uremic syndrome (HUS). STEC strains carry inducible lambda phages integrated into their genomes that encode Stx 1 and/or 2, with several allelic variants each one.
Ibarra, Cristina Adriana, Amaral, María Marta, Palermo, Marina Sandra   +2 more
openaire   +3 more sources

The Natural Quassinoid Brusatol Enhances Venetoclax Efficacy and Overcomes Resistance in Myeloid Leukemias

Cancer Science, EarlyView.
Schematic illustration of the mechanisms by which the natural quassinoid brusatol induces apoptosis in myeloid leukemias and enhances venetoclax efficacy via p53‐dependent apoptosis and mitochondrial dysfunction. ABSTRACT While venetoclax‐based combinations have shown promising results in acute myeloid leukemia (AML), the remission duration is ...
Shin‐ichiro Kawaguchi, Kazuya Sato, Junko Izawa, Norihito Takayama, Hiroko Hayakawa, Ken Suzaki, Susumu Goyama, Chiyoko Kato, Eiji Sakashita, Kaoru Tominaga, Hitoshi Endo, Yoshinobu Kanda   +11 more
wiley   +1 more source

Draft Genome Sequence of an Escherichia coli O157:H43 Strain Isolated from Cattle [PDF]

, 2013
Here we report the draft genome sequence of an Escherichia coli O157:H43 strain, designated T22, with an atypical virulence gene profile and isolated from healthy cattle.
Maróti, Gergely, Szűcs, Attila, Sváb, Domonkos, Horváth, Balázs, Tóth, István   +4 more
core   +1 more source

Prospective Trial on Tolerability and Efficacy of Adjuvant Nedaplatin Plus Docetaxel for Non‐Small Cell Lung Cancer

Cancer Science, EarlyView.
The flow of this trial and the treatment schedule of adjuvant chemotherapy with nedaplatin plus docetaxel for completely resected non‐small cell lung cancer (NSCLC) (A). The primary endpoint of this study was tolerability, assessed by the completion rate of the planned four chemotherapy cycles. As a result, it was 74.3%, exceeding that reported for the
Koji Teramoto, Ryosuke Kaku, Tomoyuki Igarashi, Masayuki Hashimoto, Shoji Kitamura, Makoto Motoishi, Yuji Suzumura, Satoru Sawai, Yataro Daigo, Jun Hanaoka   +9 more
wiley   +1 more source