Results 121 to 130 of about 22,441 (226)
Genetic and Chemical Genetic Approaches to Shiga Toxin Inhibition [PDF]
, 2011 Infection with Shiga toxin-producing bacteria can place patients at risk of developing hemolytic uremic syndrome, a toxemic condition characterized by hemolytic anemia, thrombocytopenia, and acute renal failure.
Saenz, Jose
core +2 more sources
The FEBS Journal, EarlyView.Pyridoxal 5′‐phosphate (PLP) homeostasis relies on salvage enzymes, yet key metabolic branches remain undefined. We identify AKR1C isozymes as previously undescribed contributors that convert pyridoxal into pyridoxine or 4‐pyridoxolactone through reductase and dehydrogenase activities.
Nayu Kito +8 more
wiley +1 more source
PLoS ONE, 2020 The prevalence of Shiga toxin (Stx)-producing Escherichia coli (STEC) was determined by evaluating its presence in faecal samples from 155 heifers, and 254 dairy cows in 21 farms at North of Portugal sampled between December 2017 and June 2019.
Andressa Ballem +11 more
doaj +1 more source
GA enhances Shiga toxin localization to the Golgi. [PDF]
, 2015 (A) HEp-2 cells were treated with 10 μM GA for 30 min before ~100 ng/ml Shiga toxin 1 mutant was added and the incubation continued for 30 min. Subsequently, cells were fixed, permeabilized and stained with antibodies against Shiga toxin (magenta) and ...
Ieva Ailte Hjelseth (745961) +4 more
core +1 more source
The FEBS Journal, EarlyView.We investigated the potential of iloperidone as an activator of Sigma‐1 receptor (S1R) neuroprotective function in juvenile Huntington's disease (jHD). We tested iloperidone on cortical neurons differentiated from patient‐derived iPSCs, demonstrating that it acts as a S1R agonist, decreasing apoptosis, huntingtin aggregation, and oxidative stress ...
Ersilia Fornetti +11 more
wiley +1 more source
Frontiers in Cellular and Infection Microbiology, 2015 Shiga toxin-producing Escherichia coli (STEC) are a group of diarrheagenic bacteria associated with foodborne outbreaks. Infection with these agents may result in grave sequelae that include fatality.
Elias Adel Rahal +4 more
doaj +1 more source
Ligand binding represses bacterial histidine kinase activity by inhibiting its dimerization
The FEBS Journal, EarlyView.PdtaS is a kinase in the pathogen Mycobacterium tuberculosis that senses copper and nitric oxide and controls virulence gene expression, but how the kinase senses these compounds was unclear. We show that PdtaS is active as a dimer with each monomer phosphorylating the other in trans.
Gaurav D. Sankhe +6 more
wiley +1 more source
Investigation of an outbreak of bloody diarrhea complicated with hemolytic uremic syndrome
Journal of Epidemiology and Global Health, 2019 In July–August 2009, eight patients with bloody diarrhea complicated by hemolytic uremic syndrome (HUS) were admitted to hospitals in Tbilisi, Georgia. We started active surveillance in two regions for bloody diarrhea and post-diarrheal HUS.
Otar Chokoshvili +16 more
doaj +1 more source
International Endodontic Journal, EarlyView.ABSTRACT Background Dental pulp inflammation triggers immune responses involving macrophages and dental pulp stem cells (DPSCs), which interact to regulate angiogenesis essential for tissue repair. M1 pro‐inflammatory macrophages predominate early in pulpitis, and clarifying their angiogenic role is vital in identifying inflammatory regenerative ...
Dineshi Sewvandi Thalakiriyawa +5 more
wiley +1 more source
Veterinary and Comparative Oncology, EarlyView.ABSTRACT Effective chemotherapy for canine histiocytic sarcoma (CHS) has yet to be established. In our previous study, CHS cell lines were subclassified into two groups based on their gene expression profiles: Group A and Group B. This study aimed to identify novel therapeutic agents that are effective against each CHS subgroup, and we performed high ...
Hiroki Sakuma +6 more
wiley +1 more source