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Shiga Toxins as Antitumor Tools [PDF]
Toxins, 2021 Shiga toxins (Stxs), also known as Shiga-like toxins (SLT) or verotoxins (VT), constitute a family of structurally and functionally related cytotoxic proteins produced by the enteric pathogens Shigella dysenteriae type 1 and Stx-producing Escherichia ...
Aude Robert, Joëlle Wiels
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Roles of Shiga Toxins in Immunopathology [PDF]
Toxins, 2019 Shigella species and Shiga toxin-producing Escherichia coli (STEC) are agents of bloody diarrhea that may progress to potentially lethal complications such as diarrhea-associated hemolytic uremic syndrome (D+HUS) and neurological disorders.
Moo-Seung Lee, Vernon L. Tesh
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Protection against Shiga Toxins [PDF]
Toxins, 2017 Shiga toxins consist of an A-moiety and five B-moieties able to bind the neutral glycosphingolipid globotriaosylceramide (Gb3) on the cell surface.
Simona Kavaliauskiene +3 more
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AB5 Enterotoxin-Mediated Pathogenesis: Perspectives Gleaned from Shiga Toxins [PDF]
Toxins, 2022 Foodborne diseases affect an estimated 600 million people worldwide annually, with the majority of these illnesses caused by Norovirus, Vibrio, Listeria, Campylobacter, Salmonella, and Escherichia coli. To elicit infections in humans, bacterial pathogens
Erika N. Biernbaum, Indira T. Kudva
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Targeting the Early Endosome-to-Golgi Transport of Shiga Toxins as a Therapeutic Strategy [PDF]
Toxins, 2020 Shiga toxin (STx) produced by Shigella and closely related Shiga toxin 1 and 2 (STx1 and STx2) synthesized by Shiga toxin-producing Escherichia coli (STEC) are bacterial AB5 toxins.
Danyang Li +2 more
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Therapeutic Antibodies Against Shiga Toxins: Trends and Perspectives [PDF]
Frontiers in Cellular and Infection Microbiology, 2022 Shiga toxins (Stx) are AB5-type toxins, composed of five B subunits which bind to Gb3 host cell receptors and an active A subunit, whose action on the ribosome leads to protein synthesis suppression.
Izabella de Macedo Henrique +6 more
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Escherichia coli Shiga Toxins and Gut Microbiota Interactions [PDF]
Toxins, 2021 Escherichia coli (EHEC) and Shigella dysenteriae serotype 1 are enterohemorrhagic bacteria that induce hemorrhagic colitis. This, in turn, may result in potentially lethal complications, such as hemolytic uremic syndrome (HUS), which is characterized by ...
Kyung-Soo Lee +2 more
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Rapid Detection of Escherichia coli O157 and Shiga Toxins by Lateral Flow Immunoassays [PDF]
Toxins, 2016 Shiga toxin-producing Escherichia coli O157:H7 (STEC) cause food-borne illness that may be fatal. STEC strains enumerate two types of potent Shiga toxins (Stx1 and Stx2) that are responsible for causing diseases. It is important to detect the E.
Jinliang Wang +6 more
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Molecular Biology of Escherichia coli Shiga Toxins’ Effects on Mammalian Cells [PDF]
Toxins, 2020 Shiga toxins (Stxs), syn. Vero(cyto)toxins, are potent bacterial exotoxins and the principal virulence factor of enterohemorrhagic Escherichia coli (EHEC), a subset of Shiga toxin-producing E. coli (STEC).
Christian Menge
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A High-Throughput, Precipitating Colorimetric Sandwich ELISA Microarray for Shiga Toxins [PDF]
Toxins, 2014 Shiga toxins 1 and 2 (Stx1 and Stx2) from Shiga toxin-producing E. coli (STEC) bacteria were simultaneously detected with a newly developed, high-throughput antibody microarray platform.
Andrew Gehring +11 more
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