Results 91 to 100 of about 19,735 (216)

Humoral immune response to Shiga Toxin 2 (Stx2) among Brazilian urban children with hemolytic uremic syndrome and healthy controls [PDF]

, 2014
Background: Shiga toxin (Stx)-producing Escherichia coli (STEC) infection is associated with hemolytic uremic syndrome (HUS), the main cause of acute renal failure in early childhood.
Guirro, Mirian, Guth, Beatriz Ernestina Cabilio, Piazza, Roxane Maria Fontes, Souza, Renato Lopes de   +3 more
core   +2 more sources

SanA Plays a Role in Peptidoglycan Integrity in Escherichia coli

Molecular Microbiology, EarlyView.
SanA is a novel regulator of peptidoglycan synthesis, potentially through functional interplay with PBP1B‐dependent pathways. ABSTRACT Peptidoglycan synthesis and degradation are both essential for bacterial growth, and damaged peptidoglycan must be continuously repaired. In Escherichia coli, peptidoglycan required for cell elongation is synthesized by
Honoka Yamaguchi, Risa Ago, Yuhei O. Tahara, Mari Inoue, Hironori Niki, Makoto Miyata, Daisuke Shiomi   +6 more
wiley   +1 more source

OPPORTUNICTIC ENTEROBACTERIACAE AS THE CAUSE OF THE ACUTE DIARRHEA AND GUT DISBIOSIS

Инфекция и иммунитет, 2014
. Strains of Klebsiella pneumonia isolated from faces were studied to detect virulence factors of “classical” enteric pathogens causing acute diarrhea (Shigella, Salmonella, diarreagenic Escherichia coli). We haven’t detect in Klebsiella the genes encode
S. A. Egorova, M. A. Makarova, L. A. Kaftyreva   +2 more
doaj   +1 more source

Contextualized Metabolic Modelling Revealed Factors Affecting Isoflavone Accumulation in Soybean Seeds

Plant, Cell &Environment, EarlyView.
ABSTRACT Isoflavones, secondary metabolites with numerous health benefits, are predominantly found in legume seeds, especially soybean; however, their contents in domesticated soybean seeds are highly variable. Wild soybeans are known for higher seed isoflavone contents than cultivars. Here we used experimental and modelling approaches on wild soybean (
Carolina A. Contador, Ailin Liu, Ming‐Sin Ng, Yee‐Shan Ku, Siu H. J. Chan, Hon‐Ming Lam   +5 more
wiley   +1 more source

A toxin hunter in the microworld of bacteria: a project on novel inhibitors against bacterial AB5 toxins [PDF]

, 2016
[要旨] 病原性細菌が産生する蛋白性のAB5型トキシンは1個のAサブユニットと5個のBサブユニットから構成される外毒素である。両サブユニットはそれぞれ特徴的な役割を持ち，互いに巧妙に機能分担をして一つのトキシンを形成している。Aサブユニットは主に毒性に直接関与する特異的な酵素活性を有する。一方，Bサブユニットは標的細胞のレセプターに対する結合能を有し，AB5型トキシンを標的細胞に吸着させる。ここでは毒性が全く異なるAB5型トキシンとして，コレラ菌が産生するコレラトキシン（CT ...
Fujun Shen (314092), Jiandong Yang (196004), Rong Hou (149003), Yang Da (89805)   +3 more
core   +3 more sources

Characterization of Shigella dysenteriae 1 (Shiga) toxin purified by anti-Shiga toxin affinity chromatography [PDF]

Infection and Immunity, 1980
Shigella dysenteriae 1 (Shiga) toxin was purified from whole-cell lysates by antitoxin affinity column chromatography, radioiodination, and Sephacryl S-200 gel filtration of 125I-labeled affinity column eluates. Two chromatographic peaks were observed. The percentage of radioactivity in peak I samples immunoprecipitated with antitoxin ranged from 95 to
A D, O'Brien, G D, LaVeck, D E, Griffin, M R, Thompson   +3 more
openaire   +2 more sources

Influence of Gut Microbiota on Response to Immune Check Point Inhibitors in MASLD Patients With HCC: Unraveling the Connection

Cancer Medicine, Volume 15, Issue 4, April 2026.
ABSTRACT Immune checkpoint inhibitors (ICIs) have emerged as a promising treatment for various cancers, including advanced hepatocellular carcinoma (HCC). However, a significant proportion of patients with HCC, particularly those with metabolic dysfunction‐associated liver disease (MASLD), exhibit resistance to ICI therapy.
Mazen Elsheikh, Mohamad Ali Ibrahim, Sherry Fares, Megha Bhongade, Karim Adhem, Ximena I. Ramirez‐Morales, Ahmed O. Kaseb, Joseph Petrosino, Manal M. Hassan, Prasun K. Jalal   +9 more
wiley   +1 more source

Low‐Intensity Pulsed Ultrasound Promotes Spinal Cord Injury Recovery by Regulating Microglia‐Mediated Neuroinflammation

CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
Low‐intensity pulsed ultrasound (LIPUS) exerts a neuroprotective effect in spinal cord injury (SCI) by regulating microglial polarization: it inhibits pro‐inflammatory M1 phenotype activation, promotes anti‐inflammatory M2 phenotype polarization, alleviates neuroinflammation, inhibits neuronal apoptosis, reduces spinal cord cavity formation, and ...
Xiaoyu Li, Yang Liu, Wanghui Liu, Tian Wang, Hanfei Shang, Hongji Zhong, Zixiang Deng, Xiaoyi Zhou, XianZhao Wei   +8 more
wiley   +1 more source

UV-Sensitivity of Shiga Toxin-Converting Bacteriophage Virions Φ24B, 933W, P22, P27 and P32

Toxins, 2015
Shiga toxin-converting bacteriophages (Stx phages) are present as prophages in Shiga toxin-producing Escherichia coli (STEC) strains. Theses phages can be transmitted to previously non-pathogenic E.
Sylwia Bloch, Bożena Nejman-Faleńczyk, Gracja Topka, Aleksandra Dydecka, Katarzyna Licznerska, Magdalena Narajczyk, Agnieszka Necel, Alicja Węgrzyn, Grzegorz Węgrzyn   +8 more
doaj   +1 more source

Global and regional source attribution of Shiga toxin-producing Escherichia coli infections using analysis of outbreak surveillance data [PDF]

, 2019
Shiga toxin-producing Escherichia coli (STEC) infections pose a substantial health and economic burden worldwide. To target interventions to prevent foodborne infections, it is important to determine the types of foods leading to illness.
Devleesschauwer, Brecht, Gill, Alexander, Majowicz, Shannon, Pires, Sara M   +3 more
core   +2 more sources