Results 61 to 70 of about 997,380 (276)

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021

Intensive Care Medicine, 2021
Laura Evans, A. Rhodes, W. Alhazzani, M. Antonelli, C. Coopersmith, C. French, F. Machado, L. McIntyre, M. Ostermann, H. Prescott, C. Schorr, S. Simpson, W. Wiersinga, F. Alshamsi, D. Angus, Y. Arabi, Luciano Azevedo, R. Beale, G. Beilman, E. Belley‐Cote, L. Burry, M. Cecconi, J. Centofanti, Angel O Coz Yataco, J. D. De Waele, R. Dellinger, Kent Doi, Bin Du, E. Estenssoro, R. Ferrer, C. Gomersall, C. Hodgson, M. Møller, T. Iwashyna, Shevin T. Jacob, R. Kleinpell, M. Klompas, Y. Koh, Anand Kumar, A. Kwizera, S. Lobo, H. Masur, Steven McGloughlin, S. Mehta, Y. Mehta, M. Mer, M. Nunnally, S. Oczkowski, T. Osborn, E. Papathanassoglou, A. Perner, M. Puskarich, J. Roberts, W. Schweickert, Maureen A. Seckel, J. Sevransky, C. Sprung, T. Welte, J. Zimmerman, Mitchell M. Levy   +59 more
semanticscholar   +2 more sources

Impact of Stress‐Induced Hyperglycemia on In‐Hospital Medical Complications in Patients With Acute Stroke: From a Large‐Scale Nationwide Longitudinal Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Aims This study aimed to explore the relationship between stress‐induced hyperglycemia (SIH) and in‐hospital medical complications in patients with acute stroke. Methods We enrolled 865,765 patients with acute stroke from the Chinese Stroke Center Alliance cohort.
Xintong Song, Yi Ju, Hongqiu Gu, Zhikai Zhu, Zixiao Li, Qian Zhang, Xingquan Zhao   +6 more
wiley   +1 more source

Diagnostic and Prognostic Significance of the Prothrombin Time/International Normalized Ratio in Sepsis and Septic Shock

Clinical and Applied Thrombosis/Hemostasis, 2022
Objective The study investigates the diagnostic and prognostic significance of the prothrombin time/international normalized ratio (PT/INR) in patients with sepsis and septic shock.
Tobias Schupp MD, Kathrin Weidner MD, Jonas Rusnak MD, Schanas Jawhar MS, Jan Forner MS, Floriana Dulatahu MS, Lea Marie Brück MS, Ursula Hoffmann MD, Thomas Bertsch MD, Julian Müller MD, Christel Weiß PhD, Ibrahim Akin MD, Michael Behnes MD   +12 more
doaj   +1 more source

Life‐Threatening Bradycardia in Anti‐NMDA‐Receptor Encephalitis and a Novel Use for Permanent Pacing

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Pediatric anti‐NMDA receptor encephalitis (pNMDARE) is an autoantibody‐mediated disorder that can cause severe autonomic dysfunction, including symptomatic bradycardia and asystole. Dysautonomia can last for years, making it very challenging to manage.
Sarah Tucker, Abhijit Das, Andres Jimenez, Areeba Basit, Yike Jiang, Emily A. Smitherman, Heather Van Mater, Taylor Howard, Alexander J. Sandweiss, Kristen S. Fisher   +9 more
wiley   +1 more source

Microbiological and Clinical Characteristics of Pediatric Sepsis Patients with and without Septic Shock: A Retrospective Study at a Tertiary Pediatric Hospital in China

Children
Background: Pediatric sepsis, a life-threatening condition, often progresses to septic shock. However, microbiological and clinical profiles between pediatric sepsis patients with and without septic shock remain underexplored. Methods: This retrospective
Kai-Cheng Peng, Qin-Yuan Li, Lin Chen, Yan Zhao, Hui Liu, Zhen-Xuan Kong, Zheng-Xiu Luo   +6 more
doaj   +1 more source

Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.

Journal of the American Medical Association (JAMA), 2020
Importance The combination of ascorbic acid, corticosteroids, and thiamine has been identified as a potential therapy for septic shock. Objective To determine whether the combination of ascorbic acid, corticosteroids, and thiamine attenuates organ ...
A. Moskowitz, David T. Huang, P. Hou, Jonathan Gong, P. Doshi, A. Grossestreuer, L. Andersen, L. Ngo, R. Sherwin, K. Berg, M. Chase, M. Cocchi, Jessica B. McCannon, Mark A. Hershey, A. Hilewitz, M. Korotun, L. Becker, R. Otero, J. Uduman, Ayan Sen, M. Donnino   +20 more
semanticscholar   +1 more source

The temporal trends and short‐ and long‐term mortality of people with acute myocardial infarction and rheumatoid arthritis: a nationwide cohort study

Arthritis Care &Research, Accepted Article.
Aims We investigated whether a diagnosis of rheumatoid arthritis (RA) affects the quality of inpatient acute myocardial infarction (AMI) care and long‐term mortality post‐AMI. Methods We analysed data from 784,091 adults, 6,047 with a diagnosis of RA, from England and Wales hospitalised with AMI between 2005 and 2019 from the MINAP registry, linked ...
Megan Butler, Nicholas Weight, Muhammad Rashid, Rodrigo Bagur, Purvi Parwani, Samantha Hider, Edward Roddy, Robert Butler, Mamas A Mamas   +8 more
wiley   +1 more source

Host‐Directed Biomaterials for Combatting Bloodstream Infections: From Macrocyclic Peptides to Immune‐Activating Cell Backpacks

Advanced Functional Materials, EarlyView.
Bloodstream infections (BSI) are one of the leading causes of mortality and morbidity in both civilian and military populations. This paper summarizes recent progress in novel treatment strategies to manage BSI arising from both bacterial and fungal pathogens using molecules, particles, and materials to elicit host‐directed immunity.
Thomas Thomou, Jagadish Krishnappa, Justin B. Schaal, Prasad Tongaonkar, Dat Q. Tran, Wenchao Gu, Yung‐Fu Chang, Michael E. Selsted, Shaoyi Jiang, Samir Mitragotri, Michael Super, Christopher J. Bettinger   +11 more
wiley   +1 more source

Baseline Values of Left Ventricular Systolic Function in Preterm Infants With Septic Shock: A Prospective Observational Study

Frontiers in Pediatrics, 2022
Background and AimGuidelines recommended that cardiac index (CI) of term infants with septic shock should reach the target level of 3.3–6.0L/(min⋅m2). However, there are still no standard values for preterm infants with septic shock.
Junjuan Zhong, Chun Shuai, Yue Wang, Jing Mo, Dongju Ma, Jing Zhang, Yingyi Lin, Jie Yang, Xiuzhen Ye   +8 more
doaj   +1 more source