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Butyrate: More Than a Short Chain Fatty Acid
Current Nutrition Reports, 2023The mechanistic understanding of the importance and the potential benefits of the gut microbiome has exploded in potential roles in human health and disease. Short chain fatty acids (SCFAs), including butyrate, are one of the key metabolic end products that has been a major focus of microbiome understanding.
Osman Mohamed Elfadil +5 more
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1999
Many carbohydrates present in plant foods exhibit complex structures. Thus, whilst the small intestine has the capacity to breakdown a limited number of polysaccharide compounds, different dietary carbohydrates still reach the colon. These include cell wall polysaccharides and related compounds (10–30 g/d), resistant starch (5–20 g/d) and varying ...
Demigné, Christian +2 more
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Many carbohydrates present in plant foods exhibit complex structures. Thus, whilst the small intestine has the capacity to breakdown a limited number of polysaccharide compounds, different dietary carbohydrates still reach the colon. These include cell wall polysaccharides and related compounds (10–30 g/d), resistant starch (5–20 g/d) and varying ...
Demigné, Christian +2 more
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Short chain fatty acid in intestinal obstruction
The Japanese Journal of Surgery, 1983Short chain fatty acid (SCFA) and enteric bacteria in enteric fluid of 26 patients with non-strangulated intestinal obstruction were investigated. Sixteen to 905 mg/L of SCFA was detected in all the samples and acetic, propionic and lactic acid were prominent in the fraction.
T, Fukushima +4 more
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2016
Short-chain fatty acids are formed in the colon as a result of microbial fermentation (Bifidobacterium and Lactobacillus) of undigested bioactive carbohydrates, including prebiotics and dietary fiber, and their significant role in orchestrating colon carcinogenesis is of current interest among researchers.
Maya Raman, Padma Ambalam, Mukesh Doble
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Short-chain fatty acids are formed in the colon as a result of microbial fermentation (Bifidobacterium and Lactobacillus) of undigested bioactive carbohydrates, including prebiotics and dietary fiber, and their significant role in orchestrating colon carcinogenesis is of current interest among researchers.
Maya Raman, Padma Ambalam, Mukesh Doble
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Short-chain fatty acid, acylation and cardiovascular diseases
Clinical Science, 2020Abstract Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide. Metabolic dysfunction is a fundamental core mechanism underlying CVDs. Previous studies generally focused on the roles of long-chain fatty acids (LCFAs) in CVDs.
Xiao-Feng Chen +2 more
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Short-chain fatty acids and cancer
Trends in CancerShort-chain fatty acids (SCFAs), derived from the diet and the microbiota, serve as crucial links between the diet, gut microbiota, metabolism, immunity, and cancer. They function as energy sources through β-oxidation and regulate macromolecular synthesis, G protein-coupled receptor (GPCR) and histone deacetylase (HDAC) activities, protein ...
Shan Li +5 more
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Short-Chain Fatty Acids in Ulcerative Colitis
Nutrition Reviews, 2009Short-chain fatty acids (SCFA), a by-product of anaerobic fermentation of undigested carbohydrates within the colon, are an important energy source for colonic epithelial cells. It has been proposed that ulcerative colitis, a chronic inflammatory condition of the colon, may result from a metabolic defect in SCFA oxidation in the colon and that this ...
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Effects of short chain fatty acids on seedlings
Plant, Cell and Environment, 1982Abstract. Primary roots of lettuce show no appreciable diminution of sensitivity of SCFA between 24 and 72 h, so it is likely that all actively growing primary roots are susceptible to inhibition by SCFA. While roots do not recover from long exposures to high concentrations of SCFA, partial recovery is seen following exposure to intermediate levels.
Corinne E. Ulbright +2 more
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Transport of Short Chain Fatty Acids
1974The present interest in the mechanisms involved in intestinal transport of short-chain fatty acids (SCFA) derives from the experiments of Smyth and Taylor [1,2] which showed that compounds of this type were transported against gradients of concentration from luminal to serosal sides of rat intestine incubated in vitro.
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