Results 281 to 290 of about 547,631 (352)

ACSL1‐Dependent Microglial Lipoimmunometabolic Reprogramming Underlies Cognitive Deficits in Alcohol Use Disorder

Advanced Science, EarlyView.
This study reveals that chronic alcohol exposure selectively upregulates ACSL1 expression in prefrontal cortical microglia, driving lipid metabolism reprogramming and lipid droplet accumulation, which activates the NLRP3 inflammasome and sustains neuroinflammation. To reverse this process, a dual‐targeted lipid nanoparticle, siACSL1@LNP‐MR, is designed
Liang Hao, Xing‐Rui Cao, Bai‐Qiang Li, Fu‐Ying Zhao, Jia‐Mei Wang, Rui‐Kang Gao, Zhi‐Peng Cao, Zhen‐Xian Du, Hua‐Qin Wang   +8 more
wiley   +1 more source

Fecal Short-Chain Fatty Acids in Colorectal Cancer Patients Versus Healthy Controls: A Systematic Review and Meta-Analysis. [PDF]

J Clin Med
Sylwestrzak T, Ciosek M, Pastuszak K, Jastrzębski T.   +3 more
europepmc   +1 more source

Mitophagy and Ubiquitination Coordinate Context‐Specific Mitochondrial Quality Control and EMT/MET Plasticity to Drive Cancer Cell Invasion

Advanced Science, EarlyView.
Metastatic invasion emerges when tumor‐intrinsic programs and microenvironmental forces converge on mitochondrial quality control. A context‐stratified framework links mtROS, mtDNA integrity, mechanics and nutrient/oxygen cues to fission–fusion remodeling, mtUPR and mitophagy.
Bin‐Hsu Mao, Bo‐Kai Su, Ying‐Jan Wang, Ting‐Yuan Tu   +3 more
wiley   +1 more source

Gut Microbiota and Short-Chain Fatty Acids in the Pathogenesis of Necrotizing Enterocolitis in Very Preterm Infants. [PDF]

Acta Naturae
N Kukaev E, Tokareva AO, Krogh-Jensen OA, Lenyushkina AA, Starodubtseva NL.   +4 more
europepmc   +1 more source

Creating Cell‐Based Hybrid Noodles for Sustainable and Nutrient‐Balanced Diets via a Serum‐Free and Animal‐Free 3D Co‐Differentiation System

Advanced Science, EarlyView.
This study develops a 3D co‐culture and co‐differentiation system for porcine muscle stem cells (pMuSCs) and mesenchymal stem cells (pMSCs) on edible starch‐based scaffolds. The system simultaneously generates myotubes and adipocytes without using serum or chemical inducers.
Xin Guan, Luyi Wang, Wanqiang Sun, Yiwei Feng, Dandan Wang, Haohao Tang, Zhenwu Ma, Guocheng Du, Jian Chen, Jingwen Zhou   +9 more
wiley   +1 more source

Supplementation with short-chain fatty acids and a prebiotic improves clinical outcome in Parkinson's disease: a randomized double-blind prospective study. [PDF]

Sci Rep
Hegelmaier T, Duscha A, Desel C, Fuchs S, Shapira M, Amidror S, Shan Q, Stangl GI, Hirche F, Kempa S, Maifeld A, Würtele LM, Peplinski J, Jauk D, Naim G, Shidlovsky N, Cohen A, Bennet Y, Paschold L, Dumitru CA, Obermüller-Jevic U, Hustvedt SO, Timmesfeld N, Gold R, Zapf A, Binder M, Sandalcioglu IE, Mostaghim S, Przuntek H, Segal E, Yissachar N, Haghikia A.   +31 more
europepmc   +1 more source

Short-Chain Fatty Acids Enhance EAAT2-Mediated Glutamate Clearance and Alleviate Oxidative Stress in an MPTP Mouse Model of Parkinson's Disease. [PDF]

Antioxidants (Basel)
Li W, Li J, Liu L, Hu W, Wu L, Ding S, Yu B, Jiang L, Liu H.   +8 more
europepmc   +1 more source

Fecal steroids, short-chain fatty acids, and microbiota in high- versus low-yielding forest musk deer. [PDF]

AMB Express
Dai Q, Wu J, Chen F, Jiang G.
europepmc   +1 more source

Sex-specific dynamic changes of serum short-chain fatty acids in rhesus monkeys during aging. [PDF]

Lipids Health Dis
Chen X, Ye S, Pu J, Gui S, Wang D, Zhong X, Chen W, Chen Y, Chen X, Jiang Y, Qiao R, Liu Y, Xie P.   +12 more
europepmc   +1 more source