Results 71 to 80 of about 25,877 (283)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Smart cities through urban short supply chains of food.

, 2023
The cities around the world in general and in the Mediterranean area in particular are facing tremendous challenges at the environmental, social, economic and institutional levels (Fernandez-Anez et al., 2020). Currently, cities need to be sustainable and smart (Silva et al., 2018). An economically important and innovative sector in urban areas is food
Mata, F., Dos Santos, Maria José Palma Lampreia, Baptista, Nuno, Jesus Silva, Natacha   +3 more
openaire   +2 more sources

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

The Behavior of Dairy Consumers in Short Food Supply Chains during COVID-19 Pandemic in Suceava Area, Romania

, 2021
In Romania, there is an emerging market of dairy products delivered through short food supply chains. Although this distribution system has existed since the communist period, and even though more than three decades have passed since then, the market ...
Steliana Rodino, Oana Coca, Codrin Dinu Vasiliu, Alina Butu, Gavril Stefan, Sebastian Doboș, Marian Butu, Ioan Sebastian Brumă, Lucian Tanasă   +8 more
core   +1 more source

SHORT FOOD SUPPLY CHAINS AND YOUNG PEOPLE'S ATTITUDE TOWARDS HEALTHY EATING [PDF]

Scientific Papers Series : Management, Economic Engineering in Agriculture and Rural Development, 2022
The purpose of this paper is to identify: short supply chains (SFSC) in Sibiu County, Romania, in the context of the need of transformation for the current food chains; young people's attitude towards food and a healthy lifestyle and their behavior in ...
Mirela STANCIU, Agatha POPESCU, Remus-Ioan RĂSVAN   +2 more
doaj  

Food safety requirements in case of short food supply chain [PDF]

Studia Mundi – Economica, 2018
It can be stated according to the relevant literature that the health related characteristics of the food products and the ethical values relating to the sustainable development and consumption gains on a growing importance among the preferences of the consumers.
openaire   +2 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Supply chain performance measurement: the case of the traditional food sector in the EU

, 2008
The objective of this study is to develop a sound measurement instrument of traditional food supply chain performance integrating the perspectives of different stakeholders.
Aramyan, L.H., Molnar, A., Gellynck, Xavier, Gellynck, X., Molnar, Adrienn, Aramyan, Lusine   +5 more
core   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source